Omsii - Path - Wbc Disorders

Front 1

Qualitative WBC defects - def.

Back 1

defects in structure and function

Front 2

Unusual pathogens, "cold" abscesses and frequent infections are all signs of ____ WBC defects.

Back 2

qualitative

Front 3

Job's syndrome is an autosomal recessive disorder of neutrophils characterized by a defect in ____ and increased ____.

Back 3

defect in chemotaxis, increased IgE

Front 4

A ____ reaction is a benign, exaggerated leukocyte response.

Back 4

leukemoid reaction

Front 5

Leukoerythroblastic reaction in a woman > 50 yo is usually due to ____ cancer metastatic to ____.

Back 5

breast cancer metastatic to bone

Front 6

In neutrophilic leukocytosis, neutrophil count is > ____ cells/mm^3.

Back 6

>7,000 cells/mm^3

Front 7

In neutropenia, neutrophil count < ____ cells/mm^3.

Back 7

< 1500 cells/mm^3

Front 8

Eosinophilia -- eosinophil count > ____ cells/mm^3.

Back 8

> 700 cells/mm^3

Front 9

Type I hypersensitivity, invasive helminths and hypocortisolism cause ____.

Back 9

eosinophilia

Front 10

Eosinopenia is caused by ____.

Back 10

hypercortisolism

Front 11

If a patient has basophilia, consider ____ disease.

Back 11

myeloproliferative disease

Front 12

Atypical lymphocytes are ____ stimulated.

Back 12

antigenically

Front 13

EBV, CMV, viral hepatitis and phenytoin all cause ____ ____.

Back 13

atypical lymphocytosis

Front 14

B cells have ____ receptor sites for EBV.

Back 14

CD21

Front 15

If a patient with infectious mononucleosis is placed on ampicillin, what happens?

Back 15

a rash develops

Front 16

What are heterophile antibodies?

Back 16

IgM antibodies directed against horse, sheep or bovine RBCs.

Front 17

Chronic infection, autoimmune disease and malignancy are the three most common causes of ____.

Back 17

monocytosis

Front 18

Leukemia def.

Back 18

malignant transformation of marrow stem cells.

Front 19

MC leukemia and cancer in children.

Back 19

ALL

Front 20

MC leukemia 15-60 yo.

Back 20

AML

Front 21

2nd MC leukemia in 40-60 yo.

Back 21

CML

Front 22

MC overall type of leukemia.

Back 22

CLL

Front 23

MC leukemia >60 yo.

Back 23

CLL

Front 24

Skin involvement in ____ cell leukemias.

Back 24

T cell

Front 25

ALL has ____ and ___ involvement.

Back 25

CNS, testicle

Front 26

What is the most important test for diagnosing leukemia?

Back 26

bone marrow examination.

Front 27

Acute leukemia - key finding of ____% blasts in bone marrow.

Back 27

>20%

Front 28

Chronic leukemia - key finding of ____% blasts in bone marrow.

Back 28

<10%

Front 29

How do you differentiate acute vs. chronic leukemia?

Back 29

bone marrow aspirate with blast count

Front 30

Myeloid disorders are ____ stem cell disorders.

Back 30

neoplastic stem cell disorders.

Front 31

MC chronic myeloproliferative disorder?

Back 31

polycythemia vera

Front 32

RBC count = ?

Back 32

RBC mass / PV

Front 33

Relative polycythemia - labs?

Back 33

inc RBC count

dec PV

normal RBC mass, SaO2, EPO

Front 34

Appropriate absolute polycythemia - labs?

Back 34

inc RBC mass, EPO

dec SaO2

normal PV

Front 35

Inappropriate absolute polycythemia - labs?

(ectopic secretion EPO)

Back 35

inc RBC mass

dec EPO

normal SaO2, PV

Front 36

inappropriate absolute polycythemia - labs?

(polycythemia vera)

Back 36

inc RBC mass, PV

dec EPO

normal SaO2

Front 37

Polycythemia vera --> mutation of ____ gene.

Back 37

JAK2

Front 38

Thrombotic events in polycythemia vera are due to...?

Back 38

hyperviscosity related to inc RBC count

Front 39

In polycythemia vera, pruritus after bathing is caused by mast cell release of ____.

Back 39

histamine

Front 40

What is the only polycythemia with inc PV and dec EPO?

Back 40

polycythemia vera

Front 41

What is the best initial test for polycythemia vera?

Back 41

serum EPO

Front 42

Polycythemia vera - Tx?

Back 42

phlebotomy --> reduces viscosity-induced thrombitis

Front 43

CML -- ____ translocation of ABL proto-oncogene

Back 43

t9:22

**philadelphia chromosome

Front 44

def philadelphia chromosome

Back 44

chromosome 22 with translocation

CML

Front 45

CML blast crisis -- Auer rods?

Back 45

NO! Only in AML

myeloblasts or lymphoblasts

Front 46

What is the only leukemia with thrombocytosis?

Back 46

CML

Front 47

What is the most sensitive and specific test for CML?

Back 47

BCR-ABL fusion gene

Front 48

MMM (myelofibrosis and myeloid metaplasia) - due to mutation of ____ gene.

Back 48

JAK2

Front 49

Which myeloproliferative disease is characterized by EMH, marrow fibrosis and MASSIVE splenomegaly?

Back 49

MMM

Front 50

Acute promyelocytic leukemia - translocation?

Back 50

t(15:17)

Front 51

____ infiltration is common in acute monocytic leukemia.

Back 51

gum

Front 52

Where do you find Auer rods?

Back 52

cytoplasm of myeloblasts in AML

Front 53

MC cancer and leukemia in children?

Back 53

ALL

Front 54

ALL is ____ and ____ positive.

Back 54

CD10 and Tdt

Front 55

ALL ____ offers favorable prognosis.

Back 55

t(12;21)

Front 56

ALL prognosis?

Back 56

~2/3 cure rate

Front 57

Adult T-cell leukemia is associated with ____.

Back 57

HTLV-1

Front 58

TAX gene inhibits ____ suppressor gene.

Back 58

TP53

Front 59

Skin lesions and lytic bone lesions with hypercalcemia are associated with ____ ____ leukemia.

Back 59

Adult T-cell

Front 60

MC leukemia

Back 60

CLL

Front 61

MCC of generalized lymphadenopathy in >60 yo.

Back 61

CLL

Front 62

Hypogammaglobulinemia and smudge cells are common lab findings with ___.

Back 62

CLL

Front 63

In ____, the spleen is the primary site for neoplastic cells.

Back 63

hairy cell leukemia

Front 64

Hairy cell leukemia has an absence of ____.

Back 64

lymphadenopathy

Front 65

HCL has positive ____ stain.

Back 65

TRAP

Front 66

____ has a dramatic response to purine neucleosides.

Back 66

HCL