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43 Cards in this Set
- Front
- Back
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MC blood group?
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blood group O
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Group O - antibodies in serum?
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anti-A, anti-B IgM
anti-A, anti-B IgG (most ppl) |
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M cells transport A and B antigens in ____ ____ to B lymphocytes.
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Peyer's Patches
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Group A - antibodies in serum?
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anti-B IgM
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Group B - antibodies in serum?
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anti-A IgM
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Group AB - antibodies in serum?
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No natural antibodies
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Newborns do not have natural ____ at birth.
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do not have natural antigens
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Elderly people frequently lose natural ____.
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lose natural antibodies
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Blood group AB parents cannot have ____ child.
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O
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Blood group ____ parents cannot have AB, A or B child.
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O
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Forward typing identifies ___ ___ ___.
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blood group antigens
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Back typing identifies ___ ___.
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natural antibodies
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What are the five Rh antigens?
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D, C, c, E, e
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Rh positive = ____ antigen positive.
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D antigen
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Alloimmunization -- antibodies develop against ____ ____.
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foreign antigens
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____ ____ may produce a hemolytic transfusion reaction.
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atypical antibodies
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Duffy antigen negative RBCs protect against ____ ____.
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P. vivax
malaria |
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What is the safest type of transfusion?
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autologous transfusion
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What is the most common pathogen transmitted by transfusion?
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CMV
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Newborn transfusions must be irradiated to destroy ____.
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lymphocytes
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A negative antibody screen ensures that a major crossmatch will be ____.
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compatible
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Major crossmatch = ____ ____ + ____ ____.
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patient serum + donor RBCs
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Blood group ____ = universal donors.
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O
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Blood group ____ = universal recipients.
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AB
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Allergic transfusion reaction is ____ mediated
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IgE-mediated
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IgA deficient patients must receive ____ ____ blood products.
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IgA deficient
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What causes febrile transfusion reaction?
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anti-HLA antibodies against donor leukocytes
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Where do anti-HLA antibodies come from?
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from previous exposure to HLA antigens
**blood transfusions, transplant |
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____ ____ are due to blood group incompatibility or presence of an atypical antibody.
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acute HTRs
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Tx for suspected HTRs?
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Keep IV open with normal saline, d/c transfusion.
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MC hemolytic disease of the newborn?
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ABO HDN (20-25% of pregnancies)
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ABO HDN - mom's blood group is ____, fetus' blood group is ____ or ____.
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Mom is O, baby is A or B
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Can ABO HDN affect first pregnancy?
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yes
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MCC jaundice in first 24 hours of life?
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ABO HDN
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ABO HDN will have ____ direct Coombs' test on fetal cord RBCs.
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+ direct Coombs'
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Rh HDN - mom's Rh ____, baby is Rh ____.
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mom - Rh negative, baby - Rh positive
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anemia and amt of unconjugated bilirubin
Rh HDN (><) ABO HDN |
Rh HDN > ABO HDN
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Rh HDN - unconjugated bilirubin is ____.
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free
(not bound to albumin) |
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What is kernicterus?
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Free unconjugated bilirubin deposited in basal ganglia.
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Rh HDN will have ____ direct Coombs' test on fetal RBCs.
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+ direct Coombs'
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Prevention of Rh HDN?
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Rhogam --> Rh immune globulin (anti-D globulin)
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Bilirubin absorbance = ____ nm
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450 nm
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Jaundice in newborns is treated with blue fluorescent light or sunlight. This converts bilirubin in skin to water-soluble ____.
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dipyrrole
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