Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
Polyenes bind to ____.
|
ergosterol
|
|
|
Polyene binding results in ____ ____.
|
ion channels
**protein-selective channel |
|
|
Name 2 Polyenes
|
Amphotericin B
Nystatin |
|
|
Why might Amphotericin B be harmful to host?
|
production of toxic free radicals upon its own oxidation
|
|
|
What is inhibited by azoles?
|
cytochrome P-450-dependent lanosterol 14-alpha-demethylase.
|
|
|
Which antifungal drug family inhibits cytochrome P-450-dependent lanosterol 14-alpha-demethylase?
|
azoles
|
|
|
Which Azoles does Champlin care about?
|
Ketoconazole
Fluconazole Itraconazole Voriconazole |
|
|
Describe the echinocandins - target and structure.
|
lipopeptides that inhibit synthesis of cell wall Beta-(1,3)-glucans.
|
|
|
Which echinocandins do we need to know by name??
|
caspofungin
|
|
|
Allylamines - what do they inhibit?
|
squalene epoxidase --> ergosterol biosynthesis
|
|
|
Name two allylamines.
|
Terbinafine (commonly used, OTC)
Naftifine |
|
|
Griseofulvin - describe how it works!
|
inhibits mitosis by interfering with microtubule function
|
|
|
How do we make antifungal chemotherapies useful in topical form?
|
incorporate systemic agents into lotions, ointments, powders, etc.
|
|
|
When are topical antifungals used?
|
used mostly for cutaneous, oral and vaginal mycoses.
|
|
|
____ and ____ usually require long-term systemic regimens.
|
tinea capitis, onychomycosis
|
|
|
How are bacteria able to become resistant to antifungals?
|
essentially the same as those existing for bacteria except that fungi are unable to modify or destroy anti-fungal agents
|
|
|
What is the major reason we use antifungal combinations?
|
prevent emergence of resistant organisms
|
|
|
Name one antimetabolite.
|
fluorocytosine
|
|
|
What does fluorocytosine do to fungi?
|
metabolite that interferes with RNA biosynthesis by competing with uracil.
|
