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33 Cards in this Set
- Front
- Back
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What are the 6 hormones of ANTERIOR Pituitary?
(CFGLPT) |
1.Corticotropin hormone
2. Follicle-Stimulating hormone (FSH) 3. Growth Hormone (GH) 4. Luteinizing Hormone (LH) 5. Prolactin 6. Thyrotropin |
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What are the 2 drugs of the POSTERIOR Pituitary?
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1. Oxytocin
2.Antidiuretic Hormone |
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What are the 3 BIOLOGIC effects of the Growth Hormone (GH)Somatropin?
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-Promotes growth
-Promotes protein synthesis -Carbohydrate metabolism |
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What are the effects of Somatropin deficiency?
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Pediatric- short stature
Adults- reduced muscle mass |
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What are the effects of Somatropin excess?
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Pediatric- gigantism
Adult- acromegaly |
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1.What is acromegaly?
2.What is a pituitary problem with acromegaly? |
1.Growth Hormone excess
2.Pituitary adenoma |
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Treatment optoins for Acromegaly? (3)
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Surgery, Radiation, Somastatin
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What are the consequences and treatment of Somatropin deficiency?
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Absence retards growth in all parts of the body; only treatment for deficiency is replacement with human GH
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What does Sermorelin do?
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Sermorelin promotes GH, some GH deficient people may respond to it
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What are the consequences of growth hormone excess?
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Acromegaly in adults, gigantism in children; treated with surgery, radiation, or drugs
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What are the GH excess drugs?
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1.Octreotide 2.Pegvisomant (Somavert)
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1. What is Octreotide?
2. What is Octreotide most effective for? |
1. a synthetic analogue of somatostatin
2. Most effective for suppression of GH release |
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What is Pegvisomant (Somavert) most effective for?
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Most effective for the treatment of acromegaly
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How do you treat with Somatropin?
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Pediatric growth hormone-treat only those with proven GH deficiency and assess epiphyseal status annually
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What is the expected response of Somatropin?
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adults-increase of 6inches, short stature only 2 inches and not recommended
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1.What are the 5 adverse effects of Somatropin?
2.What levels should you check periodically? |
1.Hyperglycemia 2.Antibodies to GH 3.Carpal tunnel syndrome
4.Fatility in Prader-Willi syndrome (PWS)patients 5.Interaction with glucocorticoids 2. TSH |
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How should Somatropin be administered?
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-Comes in a powder, mix gently (do not shake)
-Do not give if parentally if injection if cloudy -Give 0.06mg/kg subQ 3 days a week -Give until satisfactory adult height is reached or until epiphyseal closure occurs |
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Where is Prolactin?
What does it do? |
-Produced by the anterior pituitary
-Stimulation of milk production after giving birth |
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1.Hypersecretion of Prolactin in females can lead to?
2.In males? |
1.Female:Amenorrhea, Galactorrhea, Infertility
2.Male-Libido and potency are reduced, Galactorrhea |
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1.What is Thyrotropin?
2.What is it's role |
1.an Adernocorticotropic hormone (TSH)
2.Stimulation of the thyroid gland |
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1. What is increased with Thyrotopin?
2. What is it used to diagnose? |
1. See increased thyroidal uptake of iodine, increased synthesis of thyroid hormones, increased release of thyroid hormone and thryroid growth
2. Used to diagnose thryroid cancer |
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1. What is Carbergoline (Dostinex)for?
2. What are it's adverse effects? |
1. For suppression of Prolacitn release; Dopamine agonist
2. Nausea, HA, dizziness |
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1. What is Corticotropin?
2. What is it used for? |
1. Corticotropin (adrenocorticotropic hormone; ACTH)-acts on adrenal cortex to stimulate productoin and release of adrenocotical hormones
2.Principle use is diagnosis of adrenocortical dysfunction |
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What does the Gornadotropin, FSH do?
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FSH supports sperm production in males, in females it promotes follicular growth and development
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1. What does the Gornadotropin, LH do?
2. What is it used for? |
1. LH in females promotes ovulation and formation of corpus luteum; in males LH promotes testosterone synthesis by Leydig cells
2.Employed clinically to treat infertility in men and women |
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1.What is Antidiuretic Hormone (ADH)?
2.What disease is it involved with? |
1.ADH promotes renal conservation/reabsorption of water
2.Hypothalmic Diabetes insipidus |
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With Hypothalmic Diabetes insipidus, deficiency ADH causes what?
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1.Polydipia (excessive thirst)
2.Excretion of large volumes of dilute |
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Treatment for deficient ADH includes what?
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Treatment-ADH replacement therapy
1.Desmopressin (agent of choice) 2.Vasopressin |
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Adverse effects of ADH replacement inclue what?
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1.water intoxificatin
-Side effects-drowsy, listless, and complaints of recent HA 2. Excessive vasoconstriction |
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What are the theraputic uses of Desmopressin (ADH)?
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1.Diabetes insipidus
2.Cardiac arrest 3.Postoperative abdominal distention 4.Preparation of abdominal radiography 5.Nocturnal enuresis (bedwetting) 6.Hemophilia A 7.Von Willebrand's disease |
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ADH may be administered how?
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-PO
-Intra-nasal -IV -SubQ -BUT NOT IM |
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How is Oxytocin produced?
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Produced by neurosecretory cells of hypothalmus and transported down axons of cells for storage in posterior pituitary
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What does Oxytocin do?
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Two Roles:
1.Promotion of uterine contraction during labor 2. Stimulation ejection during breastfeeding |
