Old Pharm

Front 1

Thyroid hormones have profound effects on ___? 4

Back 1

1. metabolism
2. cardiac function
3. growth
4. development

Front 2

Thyroid hormones stimulate the ____ of most cells and _____ of cardiac contraction.

Back 2

stimulate the metabolic rate of most cells

and increase force of and rate of cardiac contraction

Front 3

Name the 2 thyroid hormones and 1 characteristic each.

Back 3

1. Triiodothryronine (T3)
-more potent than T4

2. Thyroxine (T4)
-is converted to T3 in most tissues

Front 4

What are the 3 Thyroid Hormone actions

Back 4

1. Stimulation of energy use
2. Stimulation of the heart
3. Promotion of growth and development

Front 5

Name the 3 Thyroid test

Back 5

1. Serum TSH
2. Serum T4 Test
3. Serum T3 Test

Front 6

Which Thryoid test is the most sensitive method for diagnosing hypothryroidism?

Back 6

Serum TSH

Front 7

Which Thyroid test measures total thryroxine for monitoring, screening, and replacement therapy? (Confirms diagnosis)

Back 7

Serum T4 Test

Front 8

Which Thryoid test measures total triiodothyronine, and used for hyperthyroidism and monitoring therapy?

Back 8

Serum T3 Test

Front 9

What is Hypothyroidism?

Back 9

Severe deficiency of thyroid hormone
-Myxedema (adults)

Front 10

Name some of the clinical presentations (adults) of Hypothyroidism. 8

Back 10

1. Pale, puffy, and expressionless face
2. Cold and Dry skin
3. Brittle hair or hair loss
4 HR and Temp lowered
5. Lethargy, intolerance to cold
6. May have mental impairment
7. May have enlarged thyroid gland
8. Associated with Hashimoto's disease (chronic autoimmune Thyroiditis)

Front 11

1. Hypothyroidism lab values

2. Treatment with thyroid replacement is _____?

Back 11

1. low serum T4 and high TSH


2. replacement is LIFELONG

Front 12

1. Severe deficit of Thyroid hormone in children is called ___?

2. Name the Clinical presentation in children (3)

Back 12

1. Cretinism

2. A. Mental Retardation
B. Derangement of growth (large protruding tongue, potbelly, dwarfish appearance)
C. Impairment in nervous system, bones, teeth, and muscles

Front 13

What are the 2 major forms of Hypothyroidism?

Back 13

1. Grave's disease (most common)

2. Toxic nodular goiter (Plummer's disease)

Front 14

Name the 5 characteristics of Graves' disease.

Back 14

1. More common in Females
2. Thyrotoxicosis (Thyroid Crisis)
3. Exophthalmoses (Bugged Eyed)
4. Rapid HR with possible dysrythmias

5. CNS effects: nervousness, rapid flow of speech, insomnia, muscle weakness,intolerance to heat, sweaty skin, and weight loss

Front 15

Refer for _____ for Toxic Nodular Goiter (Plummer's Disease).

Back 15

refer for surgery or radiaton

Front 16

1. Thyrotoxicosis is also called _____ and _____ and exhibits ____ of thyroid hormones.

2. S/S of Thyrotoxicosis are : 3

Back 16

1. Thyrotoxicosis is also called a Thyroid Crisis or a Thryoid Storm

2. Hyperthermia, Tachycardia, and profound weakness

Front 17

1.What do you use Propanolol to treat in relation to Thyrotoxicosis?

2. Lab values of hyperthyroidism?

3. Caused by/

Back 17

1. treatment of dysrythmias

2. Low TSH levels

3. Thyroid-stimulating immunoglobulins (TSIs)

Front 18

What are the 3 areas of treatment for hyperthyroidism?

Back 18

1. Surgical removal of thyroid tissue

2. Destruction of thyroid tissuewith radioactive iodine

3. Suppression of thyroid hormone synthesis with anti-thyroid drugs

Front 19

What are some characteristics of the treatment: Destruction of thyroid tissue with radioactive iodine?

Back 19

Destruction of thyroid tissue with radioactive iodine (potassium iodine or strong iodine solution) in cases of Thyroid Storm
-Suppresses thyroid hormone release
-May cause life-long Hypothyroidism

Front 20

1. Levothyroxine (T4) [Synthroid] is a ____?

2. Conversion of Levothyroxine (T4)is to ____ with a half life of ____.

Back 20

1. Thyroid Hormone prepartion.
Synthetic preparation of thyroxine (T4)

2. Conversion to T3, half-life is 7 days

Front 21

1. Levothyroxine (T4) [Synthroid] is highly ____ bound and used for _____ forms of hypothyroidism.

2. Was previously used as:

Back 21

1. highly protein bound, used for all forms of hypothyroidism

2.previously used as a weight loss agent

Front 22

1. Adverse effects of Levothyroxine (T4) [Synthroid] are rare unless in _____.

2. S/S of Thyroid Toxicosis: 3

Back 22

1. are rare unless in excess/overdose

2. A. Tachycardia
B. Angina
C. Tremors

Front 23

Name the 5 drugs that reduce absorption of Levothyroxine (T4) [Synthroid]

Back 23

1. Cholestyramine
2. Colestipol
3. Calcium Supplements
4. Aluminum antacids
5. Iron supplements (give 2 hours apart)

Front 24

Name the 5 drugs that accerlate metabolism of Levothyroxine (T4) [Synthroid]

Back 24

1. Phenytoin
2. Carbamazepine
3. Rifampin
4. Sertaline
5. Phenobarbital

Front 25

1. What does Levothyroxine (T4) [Synthroid] do when used with Warfarin?

2. Catecholamines?

Back 25

1. Synthroid accelerates the degradation of Vit K clotting factors inhancing the effects of Warfarin (TX- decrease Warfarin dosage)

2. Increases cardiac responsiveness to catecholamines

Front 26

What does Propylthiouracil (PTU): Antithyroid Drug do?

Back 26

Inhibits thyroid hormone synthesis by:
-preventing oxidation of iodine
-preventing iodinated tyrosine from coupling

Front 27

1. What is the half life of Propylthiouracil (PTU?

2. What route is available?

Back 27

1. short-about 75-120min

2. ONLY AVAILABLE ORALLY

Front 28

What are the 3 theraputic uses of Propylthiouracil (PTU)?

Back 28

1. Graves' disease
2. Adjunct to radiation therapy
3. Preparation for thyroid surgery
-thyrotoxic crisis

Front 29

Adverse effects of Propylthiouracil (PTU): 4

Back 29

1. Agranulocytosis (check WBC)
2. Hypothryroidism
3. Pregnancy and Lactation
4. Stop drug immediately if jaundice, fever/chills, sore throat, bleeding gums

Front 30

What is Radioactive Iodine-131 (131I)?

Back 30

Radioactive isotope of stable iodine; emmits gamma and beta rays

Front 31

What is Radioactive Iodine-131 (131I)used in?

Back 31

Grave's Disease

Front 32

1. What is the effect of Radioactive Iodine-131 (131I) on Grave's disease?

2. Advantages?

3. Disadvantages?

Back 32

1. Effect on the thyroid (destruction of thyroid tissue)

2. Advantages of (131I) therapy: low cost, less risk, less discomfort, no surgery or risk of death

3. Disadvantages (131I) delayed in effect and incidence of delayed hypothyroidism

Front 33

1. What are Radioactive Iodine-131 (131I) candidates? 2

2. Action? 2

Back 33

1. Patients over 30, Contraindicated in pregnancy and lactation

2. The drug is taken up by the thyroid gland and destroys the cells to reduce hyperthyroidism

2. Produces clinical remission of hyperthyroidism with destruction of thyroid gland

Front 34

What is Nonradioactive Iodine?

Back 34

1. Strong Iodine solution (Lugol's solution)
- used to suppress thyroid function in preparation for thyroidectomy?

Front 35

What are the adverse affects of Nonradioactive Iodine? 7

Back 35

1. Brassy tast
2. burning sensation in mouth and throat
3. Soreness of the teeth and gums
4. Frontal Headache
5. Coryza
6. Salivation
7. Varios skin eruptions