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23 Cards in this Set
- Front
- Back
- 3rd side (hint)
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northern US has these two types of fungal infections primarily
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Candida and Aspergillus
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southern US has this type of fungal infection primarily
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Fusarium
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risk factors for anterior fungal infection
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trauma, CLs, chronic corneal issues, OSD, immunocompromised Pts, long term topical use
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therapy for fungal keratitis is long and toxic, therefore need _____ of type of infectious agent
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evidence
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MOA of amphotericin B
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bind to membrane ergosterols and promote permeability
(-cidal or -static?) |
-cidal at high concentrations
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SE of amphotericin B
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nephrotoxicity
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amphotericin B demonstrates antagonism with:
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miconazole
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first line of defense for Candida infection
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amphotericin B
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only FDA approved topical Tx for fungal infections
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Natamycin
(effective against which strains primarily?) |
Fusarium, Aspergillus, Curvularia, Acremonium
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pyrimidines MOA:
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block thymidine sythetase
(why are pyrimidines used in combination with other drugs?) |
due to resistance
flucytosine oftentimes used with amphotericin B |
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SE of flucytosine
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bone marrow depression
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azoles MOA
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inhibit synthesis of membrane ergosterols
(what is a SE of this inhibition?) |
also inhibits P450 enzymes in the liver
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ketoconazole and itraconazole are:
-static or -cidal? which type of antifungal? |
-static
-azoles |
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fungistatic against Candida and Cryptococcus
SE GI problems |
fluconazole
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drug of choice for Aspergillus infections
Preg Cat D SE Visual Disturbances |
Voriconazole
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MOA of echinocandins (-fungins)
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target cell wall synthesis of peptidoglycans
(this allows for more selectivity, and more -cidal action) |
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fungicidal
broad spectrum SE blood dyscrasias, pulmonary edema |
caspofungin
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must be compounded
fungicidal active against Candida and C. albicans SE anaphylaxis, hepatic failure, renal failure |
micafungin
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fungicidal
not dose adjusted for hepatic insufficiency used primarily against Candida infections many SE |
anidulafungin
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some Tx types for parasites/protozoa
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biguanides and diamides
PHMB, brolene, polymixicin B, neomycin B, clotrimazole |
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Tx of yeast
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amphotericin B
OR micanozole |
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Tx of filamentous fungi
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natamycin
subconj injections of fluconazole oral fluconazole, ketaconazole, itraconazole |
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Tx of fungal endophthalmitis
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(virtually everything)
amphotericin B fluconazole ketoconazole flucytosine itraconazole caspofungin |
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