Oc Pharm Antifungus

Front 1

t/f fungi are suspectible to cell wall inhibiting antibacterial drugs such as the penicillins, cephalosporins, and bacitracin

Back 1

ALSE
cell wall does NOT contain peptidoglycan, so none of these have any efect

Front 2

whiel humans contain cholesterol, fungal cells contain

Back 2

ERGOSTEROL.
This difference allows antifungal drigs to bind to erosterol or damage it, while still being less toxic to human host cells

Front 3

fungal infections are known as

Back 3

mycoses

Front 4

two common funal eye infections

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fungal keratitis and endohthalmitis

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t/f widespread use of steroids have caused an increase incicidence of fungal corneal ulcers

Back 5

true

Front 6

Granuloma formation involves

Back 6

cell mediated immune rsponse!
SUPPRESSION of this respond can lead to reactivation and dissemination of asymptomatic funal infections leadin to opportunistic fungi diseases

Front 7

t/f funi contain endotoxins in their cell walls and produce exotoxins

Back 7

FALSE

Front 8

Filamentous fungi pathogens

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Aspergillus
Acremonium
Fusarium solani

Front 9

Common fungal ocular year pathogen

Back 9

Candida

Front 10

Most common dimorphic fungi ocular pathogen

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histoplasmosa

Front 11

Polyene drugs include

Back 11

Amphotercin B, nystatin, and natamycin. These bind to ergosterol in funi, increase ints permeability

these are FUNGICIDAL

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Inhibiton of sterol synthesis are drugs known as

Back 12

IMIDAZOLES:
micoazole, ketoconazole, clotrimazole, econazole

FUNGISTTIC at low, FUNGICIDAL at hih dosage

Front 13

A fluorinated pyrmidine that interferenes with RNA and DNYA snythesis is

Back 13

Flucytosine

Front 14

Inhibitions of fungi mitosis

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GRISEOFULVIN

Fungistatic

NOT USED FOR OCULAR INFECTIONS

Front 15

The only antifungal drug commercially available in US as topical opthalmic drug is

Back 15

NATAMYCIN

Front 16

t/f antifungal agents penetrate the eye poorly when used systemically or topically

Back 16

TRUE
mycotic funal ulcers are thus very hard to treat

Front 17

T/F antifungals can be combined with other drugs like rifampin, or tetracycline to greate a synergist effect

Back 17

true

Front 18

Increased activity aginst candida is seen when you mix these 2 drugs

Back 18

amphoyercin B and flucytosine

Front 19

Increased activity against candida and histplasma is seen with the combination of

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amphotercin B and rifampin

Front 20

t/f the use of ocular cortocsteriod therapy during ocualr fungal disease is very hazardous and should only be done in limited sitations

Back 20

TRUE

Front 21

Amphotericin B is a ______ and since it is water soluble it should be adminsitered___

Back 21

wide spectrum polene that is FUNGICIDAL and binds to ergosterol

given thru an IV

Front 22

The DRUG OF CHOICE for coccidioides immitis, Histoplasma capsulatum, Crptococcus neoformans, Blastomyces dermatitidis, Candia and others is

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AMPHTERICIN B

Front 23

Amphotericin B can be administed by subconj injections for corneal ulcer treatment and results in

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PERMANENT yellowing of conj at LOW doses and SALMON colored con nodule at high doses

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t/f patients on systemic amphtericin B for ocular ergions should be comanaged with an internist due to its life threatening drug toxicity, including bone marrow, renal tublar toxicity and anemia

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true

Front 25

t/f Amphotericin B is FUNGICIDAL

Back 25

true

Front 26

t/f is Nystatin is FUNGISTATIC

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true

Front 27

t/f Nystatin is greatly absorbed when given orally

Back 27

FALSE

Front 28

Natamycin (pimaricin) is a _______

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poleyne that binds to ergosterol
it is a FUNGICIDAL

Front 29

Natamyycin

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POOR CORNEA PENETRATION; 5% SUSPENSION ONLY FDA TOPICAL; Only useful for Tx of superficial keratomycoses

Front 30

Miconazole is an imidazole which means

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it INHIBITS ergosterol syntheisis and causes a fungistatic effect!!

Front 31

Miconazole application

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Topical, subconjunctival and IV for keratitis;
Tx of endophthalmitis intravitreal injection

Front 32

Ketoconazole is an

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imidazole, inhibiting ergosterol synthesis

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Ketoconazole is used in combo with _________- for fusarium, apergillus, dreschslera, curvularia, and candida ocular infections

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miconazole

Front 34

Ketoconzaole application

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Topical application for Tx of Aspergillus and Fusarium corneal ulcers;

Front 35

Flucytosine is a

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fluorinate pyrimidine an analo of cytosine

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T/F Flucytosine is a prodrug

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TRUE

transported in sensitive fungal cell by an enzyme called permease.

Front 37

T/F the spectrum of action for Flucytosine is wider than Amphotericin B

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FALSE, its narrow

Front 38

Drug binding to ergosterols = ______ effect
Drug inhibiting ergosterol synthesis = _____ effect

Back 38

cidal

static

Front 39

This type of drug increases permeability resulting in electrolyte imbalance and cell lysis

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Drug binding to ergosterol in cell membrane --> Polyenes

Front 40

This drug, ___________,
due to its poor ocular penetration by oral and or topical routes, and increased toxicity by parenteral routes ocular Tx limited to external (corneal) infections caused by Candida and Aspergillus

Back 40

Nystatin