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3 Cards in this Set
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factors of transfer across uterus (five)
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1. Area of transfer/diffusion difference;
2. Molecular weight; 3. Pka of drug (high pKA least cross); 4. Protein binding (high binding equals decreased transfer (why bupivacaine better than lidocaine); 5. Lipid solubility: decrease liability means decreased transfer |
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obstetrics: inhaled anesthetic (5)
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all cross placenta;
Mac decreased 30 to 40% in pregnancy (progesterone, beta endorphins); decrease uterine blood flow; dose-dependent uterine relaxation (except nitrous) causes decreased FHR liability (less than opioids or IV agents) |
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obstetrics: induction agents
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effective thiopental onUBF known (4 mg/kg)
propofol: risk of decrease in UBF; no advantages of either: ketamine; hypertonus in seconds trimester ketamine is best for hypovolemic patients |
