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112 Cards in this Set
- Front
- Back
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Obligate intracellular bacteria genus'
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Rickettsiales, Legionellales, chlamydiales
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Rickettsiales ssp
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Rickettsiaceae, Anaplamataceae
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Legionellales ssp
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Coxillaceae
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Chlamydiales ssp
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Chlamydiaceae
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Richettsiaceaea ssp
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Richettsia
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anaplasmatoaceae ssp
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anaplasma, ehrilichia, neorickettsia
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Coxiellaceae ssp
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coxiella
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Chlamydiaceae
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chlamydia
chlamydophila |
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Other obligate intracellular bacteria
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lawsonia
mycobacterim lepamurium? |
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Rickettsiales characteristics
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atmospheric: aerobes
Location: obligate intracellular |
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Rickettsiales diagnosis
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blood smears
serology PCR |
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RicketsialesHabitat
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"cell tropism" - predilection to infect endothelial cells, erthrocytes, phagocytes, platelets
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obligate intracellular bacteria that infect endothelial cells
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Rickettsia
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obligate intracellular bacteria that infects phagocytic cells
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ehrlichia, neorickettsia, coxiella
anaplasma phagocytophilum |
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obligate intracellular bacteria that infects erythrocytes
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anaplsma marginale
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obligate intracellular bacteria that infects platelets
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anaplsma platys
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Rickettsiales disease transmission
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systemic:flue like syndrome
Rickettsia/Ehrlichia/Anaplasma : Ticks Neorickettsia: Flukes/trematodes |
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Coxiella disease transmission
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reproductive discharges, feces urine, milk, and ticks
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Rickettsia rickettsii
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Rocky Mtn Spotted Fever
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Ehrlichia canis
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Canine monocytic ehrlichiosis
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Ehrlichia ewingii
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canine granulocytic ehrlichiosis
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Ehrlichia ruminanatium
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Aftrican Heartwater Disease
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Anaplsma marginale
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Anaplsmosis
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Anaplsma phagocytophilum
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Equine Granulocytic Ehrlichiosis
Canine Granulocytic Ehrlichiosis Bovine Tick-Borne fever |
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Anaplsma platys
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Canine cyclic thrombocytopenia
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Neorickettsia helminthoeca
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Salmon poisoning
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Neorickettsia risticiii
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Potomac Horse Fever
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Coxiella burnetii
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Q fever
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Ehrlichia ruminantium
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Cowdria ruminanatium
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Anaplasma phagocytophilum
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Ehrlichia phagocytophila
Ehrlichia equii |
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Anaplasma platys
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Ehrlichia platys
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Neorickettsia Risticii
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Ehrlichia risticii
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Coxiella burnetii
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Rickettsia burnetti
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Rickettsia rickettsii
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Rocky Mountain Spotted Fever
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Rickettsia rickettsii hosts
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people, dogs
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Rickettsia rickettsii cell tropism
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endothelial cells
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Rickettisa rickettsii reservoir
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small mamammals
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Rickettsia rickettsii reservoir
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small mammals
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Rickettsia rickettsii transmission
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ticks
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Rickettsia rickettsii transmission to humans
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Dog to tick to humans, NOT dog to humans
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Rickettsia rickettsii pathogenesis
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infect endothelial cells, escape phagosome, damage endothelial cells, cause vasculitites, hemorrhage, edema and thrombosis
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Ricettsia rickettsii damages endothelial cells by
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phospholipase and reactive O2 intermediates
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Rickettsia rickettsii signs
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fever, vomiting, diarrhea, thrombosis, small hemorrhages, lymph node enlargement, joint and muscle tenderness
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Rickettsia rickettsii diagnosis
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serology, PCR
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Rickettsia rickettsii cell tropism
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endothelial cells
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Ehrlichia is an intracellular parasite of
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leukocytes, monocytes, macrophages, and neutrophils, granulocytes
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Ehrlichia that infects monocytes and macrophages
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E. canis
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Ehrlichia that infects granulocytes
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E ewingii
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Ehrlichia pathogenesis
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infects phagocytes, inhibits phagosome-lysosome fusion
vasculitis, thrombocytopenia, leukopenia, anemia, can be acute & chronic |
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Morula means
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mulberry
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Ehrlichia canis and ewingii acute phase
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fever, lymph node enlargement
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Ehrlichia canis, equingii subclinical phase
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asymptomatic, elimination of bacterium
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Ehrlichia canis, and ewingii chronic phase
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vasculitis, thrombocytopenida, hemorrhage
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Ehrlicia canis, ewingii zoonosis
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Human granulocytic ehrlichiosis
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Ehrlichia canis zoonosis
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rare
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E. chaffeensis
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Human monocytic ehrlichiosis
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E. chaffeensis is similar to
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E. canis
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E. ruminantium
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African Heartwater, disease
Host: ruminants (sheep, goats, cattle) Ticks replicates in lymph nodes, spleen, endothelial cell, vacultitis, hemorrhage |
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How many species for Anaplasmataceae
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3
A. marginale A phagocytophilium A. platys |
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A marginale infects
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infects erythrocytes of cattle
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A. phagocytophilum infects
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infects granulocytes of ruminants, horses, dogs and humans
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A. platys infects
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infects platelets of dogs
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A. marginale is also called ? and causes??
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Bovine anaplasmosis
anemia |
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A. marginale/Bovine Anaplasmosis disease stages
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incubation stage, developmental stage
convalescent stage carrier stage |
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Anaplasma marginale is persistant because it has?
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antigenic variation
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Anaplasma marginale/Bovine Anaplasmosis prevention
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Test and Revmove Carriers
Tetracycline/doxycycline Rx Vaccine decreases diseases Vector control |
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A. phagocytophilum hosts
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horese, dogs, people, ruminants
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In dogs A. phagocytophilum causes
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Canine Granulocytic Ehrlichiosis along with E. Canis
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In horses A. phagocytophilum causes
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Equine Granulocytic Ehrlichiosis
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In cattle A. phagocytophilum causes
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Tick-borne fever (Europe)
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A. phagocytophilum reservoir is?
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rodent, wildlife
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A. phgocytophilum transmission is via
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Tick
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A. phagocytophilum pathogenesis :
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Infects neutrophils
inhibits phagosome-lysosome fusion inhibits respiratory burst delays apoptosis of neutrophils vasculititis:thrombosis/thrombocytopenia |
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A. platys host
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dogs
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A. platys reservoir
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unknown
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A. platys transmission
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unknown:ticks?
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A. platys pathogenesis
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infect platelets, immune-mediated destrcutions, immune-mediated thrombocytopenia
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Neorickettsia is transmitted
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NOT by ticks
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Neorickettsia reservoirs is
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infected flukes (trematodes) with snails as an intermediate host
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Neorickettsia transmission is by
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ingestion of the fluke
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Neorickettsia causes
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enteric infections
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N. helminthoeca
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Salmon Poisoning
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N. risticii
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Potomac Horse Fever
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Neorickettsia helminthoeca causes ?? in ??
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salmon poisoning in raccoons, skunks, dogs, bears, etc.
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Neorickettsia helminthoeca reservoir is
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flukes: intermeidate hosts are snails, fish, with a pacific northwest distribution
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Neorickettsia helminthoeca is transmitted by
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ingestion of infected fish
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Neortickettsia helminthoeca/Salmon Poisioning pathogenesis is
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invades intestinal epithelium
hematogenous spread to lympthatic tissue |
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neorickettsia pathology
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hemorrhagic eteritits
lymphatic inflammation 50 - 90 case fatality rate |
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Neorickettisa diagnosis
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fluke egss in feces
exposure (Pacific NW) |
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Neorickettsia risticii causes what disease?
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Potomac Horse Fever
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Neorickettsia risticii pathogenesis
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infects monocytes: Equine Monocytic Ehrlichiosis
inhibits phagosome-lysosome infects intestinal epthelium |
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When Neorickettsia risticii infects intestinal epthelium it causes
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loss of microvilli
increased cAMP - loss of chloride ions/water watery diarrhea |
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Neorickettsia risticii complicating outcomes include
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laminitis
toxemia fatality rate of 5 - 30 % |
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Neorickettsia risticii reservoir
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flukes
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Neorickettsia transmission
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ingestion of aquatic insects
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Neorickettsia occurrence
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freshwater streams/rivers
irrigated pastures incidence:summer |
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Neorickettsia pathogenesis
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monocytes
intestinal epithelium watery diarrhea (cAMP) |
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Coxiella burnetti causes
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Q fever
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Coxiella burnetii reservoir
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mammals, ruminants:sheep and goats
birds reptiles, fish arthropods |
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Coxiella burnetii survives in the environment in
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spore-like structures
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Coxiella burnetii is shed in
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feces
urine milk reproductive discharges |
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Coxiella burnetii is transmitted via
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aerosols/airborne
ingestion arthropod bite (rare) fomites |
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Coxiella burnetii most common transmission is
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inhalation of aerosols from reproductive discharges and placentas
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Coxiella burnetii pathogenesis
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infects macrophages (alveolar, Kupffer)
replicated in phagolysosome localized to femal reproductive tract and mammary glans |
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If Coxiella burnetii is ingested it infects the
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kidney and GI tract
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Coxiella burnetii infection in animals is mostly
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asymptomatic or latent
and sporadic obortions serology often negative even though infected |
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Coxiella burnetii zoonosis
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occupational disease of farmers, veterinarians, abbatoir workers
flu-like syndrome sheep and goat research workers |
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In Slovenia in 2007 a group of vet students contracted what disease from what animal
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Q fever from sheep farm
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To control the outbreak of Q fever in the Netherlands they
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culled all pregnant animals
started transport restrictions mandatory vaccination of ruminants bulk milk monitoring |
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Coxiella burnetii has been
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weaponized
efficient aerosol transmission survives in environment |
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Q fever in humans is
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flu-like syndrome
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Q fever in ruminants is characterized by
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sporadic abortions
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