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8 Cards in this Set
- Front
- Back
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What is the average and specific cerebral blood flow (CBF)
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Avg- 50 to 55 cc/min
Gray matter- 70 cc/min White matter- 20 cc/min |
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Equation for CBF and CPP
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CBF= CPP/CVR (cerebral perfusion pressure and cerebral vascular resistance)
CPP= MAP- ICP (mean arterial pressure) |
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What are the 3 compartments of the skull according to the Monro-Kelli doctrine?
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1. brain (80%)
2. CSF (10%) 3. blood (10%) |
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Changes in ICP cause what reactions?
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Compensation in either CSF/blood by pushing these out of the skull until reach a point where ICP gets so high and there's nothing left to leave and brain herniates
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Why would the CBF vs CPP curve shift right?
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chronic hypertension so CBF is maintained at a higher CPP
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What are the 3 regulators of CBF?
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pCO2~ increase in pCO2 causes vasodilation, increase in CBF
pO2~ increase in pO2 causes vasoconstriction and decrease in CBF NO~ vasodilator, couples metabolism to amount of blood cells receive |
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How is pCO2 used clinically?
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Patient with ICP- hyperventilate to reduce pCO2, vasoconstriction, decrease CBF, decrease ICP
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What can imaging tell us in epilepsy/ vegetative state?
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Epilepsy~ areas of concern light up because increased blood flow
Vegatative state~ person told to think about specific thing, these areas light up because increased neuronal activity of area |
