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21 Cards in this Set
- Front
- Back
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21. What does Parvovirus B19 cause?
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a. Erythema infectiosum (5th disease).
b. Classically, this mild infection presents w/a red macular rash giving the slapped cheek appearance, and usually resolves w/minimal intervention. c. Maternal-fetal transmission can cause fetal infection and death. |
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22. Risk of Parvovirus B19 in first trimester vs midtrimester and later?
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a. First-Miscarriage.
b. Midtrimester and later are associated w/fetal hydrops. |
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23. Pathophys of B19 in pregnancy?
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a. Attacks fetal erythrocytes leading to haemolytic anaemia, hydrops, and death.
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24. Dx of parvovirus in pregnant mother?
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a. Check parvovirus IgM and IgG levels. (acute infection is + IgM and negative IgG.
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25. Congenital CMV symptoms?
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1. Hepatomegaly
2. Splenomegaly 3. Thrombocytopenia 4. Jaundice 5. Cerebral calcifications 6. Chorioretinitis 7. Interstitial pneumonitis b. High mortality rate (30%) c. May develop mental retardation, sensorineural hearing loss, and neuromuscular disorders. |
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26. Rubella infection in adults sx?
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a. Mild illness w/a maculopapular rash, arthritis, arthralgias, and diffuse lymphadenopathy that lasts 2-4 days.
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27. Congenital rubella syndrome (Transmission rate is highest during first trimester)?
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1. Deafness
2. Cardiac abnormalities 3. Cataracts 4. Mental retardation. b. So Dumb, blind, and deaf with heart problems. c. Later on, may develop DM, thyroid disease, ocular disease, growth hormone deficiency. |
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28. Diagnosis of congenital rubella in baby?
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a. IgM titres. Bc IgM does not cross placenta, it is indicative of primary infection.
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29. Note: Bc of risk of theoretical risk of live virus transmission,
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29. Note: Bc of risk of theoretical risk of live virus transmission,
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30. Pts do not receive the measles, mumps, and rubella vaccine until postpartum. Pts are advised to avoid preg for 1 month after vaccination.
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30. Pts do not receive the measles, mumps, and rubella vaccine until postpartum. Pts are advised to avoid preg for 1 month after vaccination.
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31. Chlamydial infection during vaginal delivery: sx in baby?
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a. 40% will develop conjunctivitis
b. >10% will develop chlamydial pneumonia. |
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32. Tx choices of chlamydia in pregnancy (all pregnant women should be screened bc of asymptomatic infection)?
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1. Azithromycin
2. Amoxacillin 3. Erythromycin b. Bc Tetracycline and doxycycline are contraindicated |
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33. Tx of pts exposed to HBV in pregnancy?
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a. Postexposure prophylaxis w/1 dose of hep B immunoglobulin and a complete hep B vaccination series is recommended.
b. Neonates of mothers who are HBsAg positive or have unknown status should be given HepB Ig at birth (preferably w/in 12 hours of birth) and should undergo hepB vaccination at birth, 1 month, and 6 months. |
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34. Note: all infants are routinely immunized w/hep B vaccine
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34. Note: all infants are routinely immunized w/hep B vaccine
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35. Congenital syphilis sx?
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a. Systemic illness
b. Maculopapular rash c. Snuffles d. Hepatomegaly/splenomegaly e. Haemolysis f. Lymphadenopathy g. Jaundice |
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36. Diagnosis of congenital syph?
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a. IgM antitreponemal antibodies which do not cross placenta.
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37. Only tx w/sufficient evidence for preventing maternal syphilis transmission to fetus and thus for treating fetal infection?
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a. PCN.
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38. What can happen if early congenital syphilis is untreated?
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a. Manifestations of late congenital syph can develop, including 8th nerve deafness, saber shins, mulberry molar, Hutchinson’s teeth, and saddle nose.
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39. Toxoplasma gondii?
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a. Protozoan parasite.
b. Infections in immunocompetent hosts are often subclinical. c. Occasionally develop fever, malaise, lymphadenopathy, and a rash as w/most viral illnesses. |
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40. When is transmission of toxo to fetus most common?
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a. When it is acquired in 3rd Tri-M.
b. Neonatal manifestations then are usually mild or subclinical. |
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41. Toxo transmitted in first trimester?
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a. Severe congenital infection:
1. Fevers 2. Seizures 3. Chorioretinitis 4. Hydro or microcephaly 5. Hepatosplenomegaly 6. Jaundice. b. Look for IgM but lack of ab’s does not necessary r/o infection. |
