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19 Cards in this Set
- Front
- Back
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1. CIN (Cervical Intraepithelial Neoplasia)?
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a. Refers to premalignant changes in the cervical EPITHELIUM that have the potential to progress to cervical cancer.
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2. Histologic features most commonly associated with CIN (Cervical Intraepithelial Neoplasia)?
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a. Cellular immaturity
b. Cellular disorganization c. Nuclear abnormalities d. ↑’d mitotic activity. |
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3. By what is the severity of CIN determined?
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a. By the portion of epithelium showing disordered growth and development.
b. The changes start at the basal layer of the epi and expand to encompass the entire epithelium. |
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4. Note: the nomenclature for cervical neoplasia divides the epithelial thickness into thirds to express the degree of abnormality.
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4. Note: the nomenclature for cervical neoplasia divides the epithelial thickness into thirds to express the degree of abnormality.
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5. CIN I (Cervical Intraepithelial Neoplasia) [formerly mild dysplasia]?
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a. The changes are restricted to the lower-third of the epithelium.
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6. CIN II?
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a. 2/3 of epithelium is involved.
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7. CIN III?
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a. >2/3 of epithelium show abnormal changes.
b. The atypical cells in CIN III can expand the full thickness of the epithelium (formerly CIS or carcinoma in situ). |
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8. When does CIN most commonly occur?
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a. During menarche and after pregnancy when metaplasia is most active.
b. It is twice as likely to be on the anterior lip of the cervix. |
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9. HPV 6 and 11?
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a. Condylomas
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10. HPV 16,18, 31, 45?
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a. Cervical dysplasia and cancer.
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11. Factors other than HPV that influence CIN?
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a. Cigarette smoking!
b. Exogenous or endogenous immunodeficiency! (HIV, SLE, chemo, chronic steroids) |
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12. When should all women begin cervical cancer screening?
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a. 3 years after they being having intercourse but no later than age 21!
b. Screening should continue on an annual basis. |
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13. When can screening decrease from annual?
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a. Beginning at age 40, women who have had 3 normal pap smears in a row may opt to be screened every 3 years.
b. All women over 30 should have high-risk HPV screening every 3 years. |
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14. When can you stop having paps?
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a. Women 70 yrs or older who have had 3 or more normal paps and no abnormal paps in the past 20 yrs may choose to stop.
b. Likewise, if a woman has had a total hysterectomy for a benign indication such as fibroids or dysfunction bleeding and she does not have a hx of abnormal pap in the past 20 yrs, she can d/c. c. Important: Women who have undergone a supracervical hysterectomy and have an intact cervix still need to continue regular screening. |
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15. ASC-US?
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a. Atypical squamous cell of undetermined significance.
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16. ASC-H?
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a. Atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion
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17. HSIL?
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a. High-grade squamous intraepithelial lesion
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18. SCC?
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a. Squamous cell carcinoma
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19. AGC?
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a. Atypical glandular cells.
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