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62 Cards in this Set

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O2 is tranferred from uterine circulation to umbilical circulation by?
Passive Diffusion
Indicators of Normoxemic state include:
"Net lactate uptake by the fetus,Small amounts of hydrogen ion are transferred from fetus to mother, No increase in oxygen consumption occurs when maternal oxygen levels increase,Healthy fetus has a normal basal pH
Fetal Oxidative Metabolism: Uterine Uptake is what 2 components
1)Placental Comsumption (40% of utake at term, higher mid-term due to high carb and A.Acid metabolism 2) Umbilical O2 consumption is uptake by fetus
Five factors Fetal O2 consumption
Substrate Availability. Fetal: Growth, Activity, Hormone Status, Organ Metabolism.
Is O2 fetal O2 consumption for growth necessary?
No…not required to survive. Can be eliminated during high stress times. May lead to IUGR if prolonged
Factors increasing Fetal Demand for O2
Increased: Fetal Activity, Glucose Uptake (mom's high BG) and increase Hormone secretion
Factors decreasing Fetal Demand for O2
Mom's Hypoxemia, Low uterine or placental blood flow, placenta abnormal, fetal disorder
Normal fetal growth is from
Adequate metabolic substrates and fetus able to use it
AGA
Appropriate for Gestational Age. Wt b/w (10-90%) "for age"
LGA
Large for Gestational Age. Wt. >90% for age.
SGA
Small for Gestational Age. Wt. <10% for age
What terms descibe birth wt. "Independent of Gest-Age
LBW,VLBW,ELBW (low, verylow, Extrm low…birth wt.) 2500, 1500,1000 gms
LBW
<2500 gm
VLBW
<1500 gm
ELBW
<1000 gm
Factors of Fetal Circulation
"Fetal Oxygen Transport,Regulation of Fetal Blood Volume,Unique Fetal Circulatory Pattern, Various Factors that Control the Distribution of Blood Flow
Oxygen content of fetal blood is determined by what formula?
[Hgb] * HGB02 (bound) + constant 1.39 ml O₂/g Hgb Hgb (oxygen-carrying capacity of hemoglobin)
Amount of oxygen dissolved in fetal plasma is?
insignificant
Normal fetal Hgb is __g/dl?
18 g/dl
Oxygen-carrying capacity of fetal blood should be
25 ml O₂/dL – this is theoretical as fetal Hgb never approaches complete saturation @ low PO2
P:50 for Fetus v. Mom ___mm Hg v. ___ mm HP
Fetal Po2 is 19-21mm and mom's 27 mm Hg
Per Rich. How does ocyhemoglob curve differ b/w mom and fetus?
Fetus stays "locked and loaded" can drop to po2"19-21) and stays 50% saturated (@P:50)
Fetal Hemoglobin does not interact as well with
with DPG to stabilize the deoxygenated hemoglobin as maternal Hemoglobin does
fetal hemoglobin has less DPG, less deoxy:hgb affinity and more…
affinity for O2, so it takes it from mom *With emphasis*
Fetal cardiac output is
biventricular (also called combined ventricular output) "BV-CVO" due to ductus arteriosus
Fetal Systemic and Pulmonary Circulations are
PARALLEL, whereas postnatal circulations are in series
The reason for parallel circulation is obvious
fetal lungs do not participate in blood oxygenation
almost complete right-to-left shunt is due to
ductus arteriosus
Can fetus increase their CVO in utero
They cannot! …even during periods of stress (damn patent ductus arteriosus)
Does fetal PNS or SNS develop first and which is more developed
The PNS is developed first, thus the baseline FHR at 40 weeks gestation is < the baseline at 26 weeks gestation
As the head decends into the pelvis, the ICP___?
Increases…Ouch! "Hello there mom...stress me out with a head squish"
Redistribution of circulation includes?
"Decreases perfusion of the splanchnic organs, kidneys, and skin-Preservation of blood flow to skeletal muscle & bone-Augmented blood flow to the heart, brain, placenta, & adrenal glands-Cardiac output does not change-Fetal pH decreases as a result of these compensatory mechanisms
FHRM: External (Indirect)
Detected through maternal abdominal wall, no membrane rupture, doesn't quantify uterine pressure
FHRM: Internal (Direct)
"Wire electrode to the scalp of the fetus, requires rupture of membrane & partially dilated cervix
Average FHR __bpm
110-160
"Tachy" FHR ___bpm
>160
"Tachy" FHR problems
Prolonged hypoxemia (result of catecholamine secretion and SNS activity),Maternal Fever,Intrauterine infection,Medications (Terbutaline (β-adrenergic agonist), Atropine)
"Brady" FHR ___ bpm
<110 for 2 min.
Why "Brady" FHR?
Fetal initial response to acute hypoxemia, or maternal HoTN
What is Variability?
The irregularity of the FHR baseline from the competing effects of the PSNS and SNS
Variability Describes?
small HR changes in the FHR
"What is the single, best non-invasive clinical indicator of fetal well-being?"
Variability
Short-term variability (beat-to-beat variability) results from the influence of ?
the PSNS
Long-term variability is?
Rhythmic fluctuations in the FHR basline that are seen over a 5-10” tracing
Normal (LT variability) frequency of such waves is
3-5 cycles/min
Lack of variability results from
hypoxemia and the decompensation of cerebral blood flow & O₂ delivery
How should you manage mom's BP?
Keep it up…SBP >95
A Periodic Changes in FHR called an acceleration is
An abrupt increase in FHR (<30 Seconds)
What is the mechanism for an accelaration?
"Fetal Movement,Uterine Contractions,Umbilical Cord Occlusion,
Periodic Changes in FHR precludes the presence of significant
fetal metabolic acidosis (reassuring)
"Early Decelerations are from what three factors?"
"1) Occur simultaneously with uterine contractions and usually are <20 bpm below baseline-2) Onset and offset of each -decel coincides with the onset and offset of the uterine contraction-3) Occurs as a result of vagal response to head compression during labor
"Late Decelerations are not good…why?"
"1) Begin 10-30 seconds after the beginning of a uterine contraction and end 10-30 seconds after the end of the uterinecontraction::2) Smooth and Repetitive::3) Classic sign of uteroplacental insufficiency and hypoxia
What is the "OMINOUS SIGNAL OF FETAL DISTRESS!"
COMBINATION OF LATE DECELS AND DECREASED/ABSENT FHR VARIABILITY
Describe Variable Decelerations
"Vary in depth, shape, and/or duration:Abrupt in onset and offset
What is the likely cause of variable decels
"Believed to be a result of vagal response to either umbilical cord compression or to substantial head compression during pushing
Healthy fetus typically can tolerate mild-to-moderate variable decels not below ___BPM
<80 BPM is bad
Fetal Distress is reassuring” vs. “non-reassuring”, what is this?
"Reassuring – suggest a restoration of confidence by a particular pattern:Non-reassuring – “inability to remove doubt”
"What's the classic sign of utero-placental insufficiency and hypoxia?"
Late Decels
What did saf says "mirrors the contractions"
early decels
What's a contraction that just won't let up?
Titanic
What is the main thing anes can do to treat fetal brady and late decels
Fix the HoTN!
Per Rich. Periodic changes are actually…
Periodic changes are FHR accelerations or decelerations that occur with contractions. Decelerations are routinely described as early, late, or variable.