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20 Cards in this Set

  • Front
  • Back
Types of collagen in OA joints
I, III, X
Types of Collagen in Healthy joints
II, IX, XI
Pathogenesis: failure of chondrocytes to
1. synthesis good matrix
2. loss of synthesis/ degradation balance
T or F: Inflammatory Cytokines do NOT exist in OA
false
Cartilage degrading enzymes are released by:
Chondrocytes
Major components of Normal Cartilage
1. 70-80% water
2. 20-30% Collagen Type II, PGs
3. 1-2% Chondrocytes
3 differences between Aging & OA cartilage
1. Denatures type II collagen is more predominant in OA
2. OA and aging cartilage differ in the amount of water and the ratio of chondroitin-sulfate to keratin sulfate
3.Degenerative enzyme activity increased in OA
3 general categories of MMPs
1. collagenases
2. stromelysins
3. gelatinases
factor responsible for induction of MMPs
IL-1
most common joints involved in RA
hands
wrist
feet
RA: Primary cell types in a hypertophied synovial lining
Fibroblast
Macrophages
Local factors involved in OA:
1. Excess weight
2. Injury
3. Occupation
4. Developmental abnormalities
Systemic factors involved in OA:
1. Sex hormones
2. Genetics: OA of Hands
3. Low vit D & C intake
% of US citizens with some radiographic evidence of changes associated with OA in the Knee; not all have symptoms
1/3
OA joint pathology:
1. gradual loss of articular cartilage
2. thickening of subchondral bone
3. Osteophytes
4. Mild, chronic synovial inflammation
Phase I:
Edema, microcracks
Phase II:
Fissuring, pitting
Phase III:
Erosion
Prevalence of RA
1-2% of general population

Women>men
No ethnic/ ratial predisposition
Symptoms of RA
1. Joint pain, stiffness, inflammation
2. Fatigue
3. Loss of appetite
4. Fever