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20 Cards in this Set
- Front
- Back
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Types of collagen in OA joints
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I, III, X
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Types of Collagen in Healthy joints
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II, IX, XI
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Pathogenesis: failure of chondrocytes to
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1. synthesis good matrix
2. loss of synthesis/ degradation balance |
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T or F: Inflammatory Cytokines do NOT exist in OA
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false
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Cartilage degrading enzymes are released by:
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Chondrocytes
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Major components of Normal Cartilage
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1. 70-80% water
2. 20-30% Collagen Type II, PGs 3. 1-2% Chondrocytes |
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3 differences between Aging & OA cartilage
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1. Denatures type II collagen is more predominant in OA
2. OA and aging cartilage differ in the amount of water and the ratio of chondroitin-sulfate to keratin sulfate 3.Degenerative enzyme activity increased in OA |
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3 general categories of MMPs
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1. collagenases
2. stromelysins 3. gelatinases |
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factor responsible for induction of MMPs
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IL-1
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most common joints involved in RA
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hands
wrist feet |
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RA: Primary cell types in a hypertophied synovial lining
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Fibroblast
Macrophages |
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Local factors involved in OA:
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1. Excess weight
2. Injury 3. Occupation 4. Developmental abnormalities |
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Systemic factors involved in OA:
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1. Sex hormones
2. Genetics: OA of Hands 3. Low vit D & C intake |
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% of US citizens with some radiographic evidence of changes associated with OA in the Knee; not all have symptoms
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1/3
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OA joint pathology:
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1. gradual loss of articular cartilage
2. thickening of subchondral bone 3. Osteophytes 4. Mild, chronic synovial inflammation |
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Phase I:
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Edema, microcracks
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Phase II:
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Fissuring, pitting
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Phase III:
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Erosion
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Prevalence of RA
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1-2% of general population
Women>men No ethnic/ ratial predisposition |
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Symptoms of RA
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1. Joint pain, stiffness, inflammation
2. Fatigue 3. Loss of appetite 4. Fever |
