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8 Cards in this Set
- Front
- Back
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Pyrimidines are held together ___________
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Hydrogen bonds
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Enzyme for the committed step of purine synthesis
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Amidophosphoribosyl transferase (APR Transferase)
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A defect in purine recycling leading to under secretion of urate and excess urate crystallization in joint capsules and kidneys
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gout
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How is gout managed?
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- Reduce inflammatory response using anti-inflammatories, steroids, colchicine
- reduce irate levels via blockage of xanthine oxidase with allopurinol, oxipurinol, creating soluble allantoin, which is secreted -use uricase to breakdown urate |
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Defect in purine recycling resulting from a deficiency in HGPRT
- leads to excess uric acid levels in ALL body fluids - blocked salvage and unused PRPP |
Lesch-Nyhan Syndrome
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Purine chemotherapy drugs that function as a purine antagonist and glutamine analogue (blocks purine synthesis
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Azaserine AND Azathioprine
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purine chemotherapy drug that inhibits purine synthesis by blocking inositol monophosphate dehydrogenase (IMP DH)
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Mycophenolate
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purine chemotherapy drug that INDIRECTLY inhibits purine biosynthesis by blocking folic acid production (I-C donor)
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Methotextrate
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