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145 Cards in this Set

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  • Back
What dietary deficiency causes the triad of:
- dermatitis (rash)
- diarrhea
- dementia
Pellagra, caused by niacin (vitamin B3) deficiency
What are long-term consequences of lack of dietary fiber?
Heart disease
Colorectal cancer
Diverticulosis
Is breastmilk a good source of iron?
No, it has only very meager amounts of iron. Therefore, if baby is solely fed by breastmilk, must give iron supplements.
How do you increase the absorption of fat-soluble vitamins, such as vitamin A?
Eat the source of the vitamin (carrots for vitamin A) along with a fat source. The fat will increase the absorption.
What are the symptoms of vitamin A deficiency?
Impaired wound healing
Night vision difficulties
Increased risk of respiratory infection
Why is vitamin K given to newborns at birth?
Placental transfer of K is poor, in contrast to vitamin A, D, and E. Breast milk is also a poor source of K. Vitamin K is needed to clot blood.
How can iron absorption be improved?
Eat food rich in vitamin C in the same meal. Helps absorb non-heme iron.
What sort of processes is zinc a cofactor in?
- Synthesis of parts of DNA/RNA
- Heme
- Release of vitamin A from the liver
- EFA, CHO and alcohol metabolism
In a child > 2 years old, what is the recommended distribution (in percentages) of calories from macronutrients (CHO, fat, protein)?
CHO: 55%
Fat: 30%
Protein: 15%
What is the order of satiety (from most satiating to the least) between the macronutrients?
Fat is the most satiating
Protein is second
CHO is the least satiating
What are the names of the 2 "families" of essential fatty acids? What is the ideal intake ratio between these two families?
Omega-3 (linolenic acid)
- includes EPA and DHA

Omega-6 (linoleic acid)

Ideal ratio is 1:1 to 4:1 of omega-6 to omega-3
What are the functions of essential fatty acids?
- Support cardiovascular, reproductive, immune, musculoskeletal and nervous systems
- Cell membranes manufacture and repair
- Prostaglandin production, which regulate heart rate, BP, clotting, fertility, conception, immune function
- Neural development in children
Is there a way in which omega-3 (linolenic acid) rich foods can not be prepared?
Cannot heat them, because heat destroys omega-3.
Functions of vitamin A
- Diverse actions in cellular regulation and differentiation
- Essential role in retina
- Decreases risk of infection
Functions of vitamin E
Anti-oxidant for fatty acids in cell membranes
Prevents LDL oxidation
Normal immune function
Function of pantothenic acid
Part of coenzyme A, which is essential for transfer of 2-carbon groups in metabolism of CHO, fatty acids, and synthesis of sterols
Function of vitamin C
Collagen synthesis
Promotes activity of aminating enzymes of certain peptides
Which vitamins are needed to prevent anemia?
• Vitamin B₁₂ and folic acid
• Vitamin B₆
• Vitamin C
• Vitamin E
Which vitamins have antioxidant properties?
A, C, E
Which vitamins help prevent CVD?
• Niacin - lowers LDL, raises HDL
• Vitamin C - antioxidative against LDL oxidation, enhance eNOS
• Vitamin E - antioxidative
• Vitamin B₆, B₁₂ and folic acid reduce homocysteine
Which vitamins have been shown to be probably protective against cancers?
• Carotenoids (a type of vitamin A) are anti-lung cancer
• Vitamin C is anti-stomach cancer
Which vitamins have immune function?
• Vitamin A
• B-vitamins
• Vitamin C
• Vitamin E
Which are the lipotropic vitamins?
Choline, vitamin B₁₂ and folic acid
- remove fat from liver
- reduce liver cancer
When does stranger anxiety develop in an infant?
9 months
What are the domains of development in infancy and childhood?
1. Cognition
2. Language
3. Fine motor
4. Gross motor
5. Adaptive/Activities of Daily Living
6. Socio-emotional
List the three constellations of behaviour in infants?
1. Easy child (40% of population)

2. Difficult child (20% of population)

3. Slow-to-warm-up child (15% of population)
What is Piaget's theoretical framework?
SPCA: 4 stages of cognitive development

• Sensorimotor (0-24 months)
• Rely on senses and motor reactions to deal with world

• Preoperational (2-7 years)
• Symbolic thought and play
• No logic/deductive thinking
• Egocentric

• Concrete operations (7-11 years)

• Abstract operations (12 years and older)
At what age can an infant get into sitting position on their own?
8 months
What BMI is considered "at risk of overweight" in children and adolescents?
85-95 percentile
Which diseases are more common in Turner's syndrome?
CHODOG

Celiac disease
Hashimoto's thyroiditis
Obesity
Diabetes (type 1 and 2)
Osteoporosis
Gonadal failure
Which hormones that normally have a role in growth in infancy and childhood, but have NO ROLE in fetal growth?

Which hormones have a role in fetal growth?
No role in fetal growth: GH, and TSH/T₄

Have a role in fetal growth: TGF-α, IGF1, IGF2, EGF, Insulin
What is the PIT-1 transcription factor needed for?
It is needed for pituitary development and hormone expression.
A defect causes deficiency in GH, PRL, and TSH.
What causes Laron dwarfism?
GH receptor mutation, leading to GH resistance.
If a child has both hypothyroidism and cortisol deficiency, what must you do first?
Must replace cortisol before giving T4, to prevent precipitating Addisonian crisis.
If there is concomitant cortisol deficiency along with ADH deficiency, what is the caveat in diagnosis?
ADH deficiency will not manifest itself until cortisol deficiency is corrected. This is because cortisol is needed for free water excretion.
Definition of:
Preterm
Neonate
Infant
Child
Adolescent
Adult
Preterm 36 weeks and less
Neonate 0-27 days
Infant 28 days - 12 months
Child 1 - 11 years
Adolescent 12 - 17 years
Adult > 17 years
What is vitamin deficiency risk of eating vegan diet?
Vitamin B12 deficiency
What time of food/mineral inhibits iron absorption?
Milk and calcium
What causes a disproportionate short stature in infants/children?
Skeletal dysplasias, such as achondroplasia (dwarfism)
What causes a proportionate short stature, with loss of height > weight?
Endocrine causes (Deficiency in GH, T4, gonadal hormones. Excess in cortisol)
- Exception is deficiency in ACTH/cortisol, and ADH. Patient will be short and thin.

Chromosome/genetic causes (Turner, Down)
What causes a proportionate short stature, with loss of weight > height?
Inadequate calories (malnutrition/malabsorption)

Chronic disease (kidney, cardioresp, hematologic)
List the psychoeducational tests used to measure intelligence.
Wechsler series
• WPPSI-III (Wechsler preschool and primary scales of intelligence, 3rd ed), for age 2½ - 6
• WISC-III (Wechsler intelligence scales for children, 3rd ed), for age 6-16
• WAIS-III (Wechsler adult intelligence scale, 3rd ed), for age 16-89

SB-V (Stanford-Binet Intelligence Scale, 5th ed)

Woodcock-Johnson Tests of Cognitive Abilities

DAS - Differential Ability Scales
List the psychoeducational tests used to measure adaptive behaviour.
1. VABS-II (Vineland Adaptive Behaviour Scales)

2. ABAS (Adaptive Behaviour Assessment System)

3. SIB-R (Scales of Independent Behaviour, Revised)
List the psychoeducational tests used to measure academic achievement.
1. WIAT-II (Wechsler Intellectual Achievement Test, 2nd ed)

2. WJ-R Tests of Achievement (Woodcock-Johnson Tests of Achievement, Revised)
What IQ is considered "intellectual disability"? How about "average"?
Intellectual disability is < 69

Average is 90-109
How long do inattentive or hyperactive/impulsive symptoms need to be present for ADHD to be diagnosed? How many symptoms?
What is the other key thing that you need to rule out?
≥ 6 symptoms of inattention or hyperactivity/impulsivity for ≥ 6 months, to a degree that is maladaptive and inconsistent with developmental level (i.e. their inattentiveness/hyperactivity must be inconsistent with their developmental age)

They need onset before age 7, and impairment of function in 2 or more settings
What are some predictors of persistence of ADHD into adulthood?
Psychosocial adversity
Psychiatric comorbidity (mood, conduct or anxiety)
Familiality
In utero, when does the most dramatic brain growth occur?
Beginning of fetal stage, especially week 8 - 14
epinephrinum, adrenaline (Tonogen inj.)
0.05-0.1-0.2! mg iv
What does the principle of mass action explain in terms of where memory is stored?
It says that neurons get grouped together when they fire together.
What are the five steps of neurogenesis?
1. Proliferation (in dentate gyrus)
2. Migration (into granule cell layer)
3. Differentiation (into immature neurons)
4. Axonal and dendritic targeting
5. Synaptic integration
What are the most significant influences on intelligence?
Genetics
Low birth weight
Nutrition (but only in developing countries)
DSM-IV def of intellectual disability
1. Significantly subaverage intellectual functioning
• IQ <= 70
2. Concurrent deficits or impairment in adaptive functioning
3. Onset before age 18
When does a child develop legible printing, and rarely reverses letters?
7 years
When does a child have gross motor ability to walk alone?
12 months
When does a child have gross motor ability to sit up on their own?
8 months
When does a child have gross motor ability to ride a tricycle?
3 years
When does a child have gross motor ability to hop or skip?
4 years
When does a child have fine motor ability to do pincer grasp?
10 months
When does a child have fine motor ability to scribble?
18 months
When does a child have fine motor ability to initiate pencil stroke?
2 years
When does a child have fine motor ability to build tower of 6 cubes?
2 years
When does a child have fine motor ability to copy a circle?
3 years
When does a child have fine motor ability to copy a square?
4 years
When does a child have fine motor ability to copy a triangle?
5 years
When does a child have fine motor ability to tie shoes?
5 years
When does a child have language ability to coo?
2 months
When does a child have language ability to say dada indiscriminately?
8 months
When does a child have language ability to have 2 word sentences?
2 years
When does a child have language ability to know age and gender?
3 years
When does a child have language ability to tell a story, and ask questions?
4 years
When does a child have language ability to name 4 colours, and print first name?
5 years
When does a child have social development of being able to have social smile?
6 weeks
When does a child have social development of being able to wave bye-bye?
10 months
When does a child have social development of being able to hug parents?
15 months
When does a child have social development of being able to parallel play?
2 years
When does a child have social development of being able to participate in associative play?
3 years
When does a child have social development of being able to participate in interactive play?
4 years
When does a child have social development of being able to play competitive games with rules?
5 years
When does a child have adaptive ability to drink from cup?
12 months
When does a child have adaptive ability to feed self?
18 months
When does a child have adaptive ability to be toilet trained?
3 years
When does a child have adaptive ability to undress self, and partially dress?
3 years
When does a child have adaptive ability to dress self completely?
4 years
What is the definition of a learning disability?
Child has significant discrepancy between his/her cognitive ability (IQ) and his/her achievement.

Their IQ profile can be uneven (e.g. bad at verbal IQ, but very good at non-verbal IQ)
What is the prevalence of ADHD in North American children?
5-15%
What are the most common comorbidities of ADHD?
Depressive disorder
Oppositional-defiant disorder
Conduct disorder
Mania/hypomania
Anxiety disorder
Learning disabilities
Tic disorder
What are the first line treatments for ADHD?
Ritalin (methylphenidate)
Dexedrine (dextroamphetamine)
What are good dietary sources of zinc?
Dark red meat
Plain yogurt
Cheddar
Ricotta cheeses
Legumes (also a good source of iron, calcium, fibre)
What kind of supplements have shown benefits in children with ADHD?
Iron, zinc, magnesium supplements.
What disabilities can FAS cause?
ALARMMERS +
- Adaptation
- Learning
- Attention (limbic system)
- Reasoning (frontal lobe)
- Memory
- Motor (cerebellum)
- Executive function (frontal lobe)
- Regulation of state (brain stem)
- Speech and language (left temporal lobe)

+ brain and neurological signs
At what age is a pregnant woman offered invasive testing without screening?
> 40 yr
What is the timing of pubertal stages in girls and boys?
Girls
• Thelarche
10 yr
• Pubarche
10.5 yr
• Menarche
13 yr
• Growth velocity peak
11.5 yr
• Precocious puberty
Thelarche < 8 yr
Menarche < 10 yr
• Delayed puberty
Thelarche > 13 yr
Menarche > 16 yr, or absence of menarche within 5 years of pubertal onset

Boys
• Gonadarche
11.5 yr
• Pubarche
12 yr
• Growth velocity peak
13.5 yr
• Precocious puberty
Gonadarche < 9 yr
• Delayed puberty
Gonadarche > 14 yr
What is the first pubertal sign in most girls? boys?
Girls: breast development
Boys: testicular enlargement
What pubic hair tanner stage is growth velocity peak at for girls?
Tanner 3 pubic hair
Approximately 11.5 years old
What is the mechanism behind the growth spurt of puberty in adolescents?
In both boys and girls, estrogen acts directly on growth plate, and also has permissive effect on GH synthesis and secretion, which promotes growth spurt.
By what bone age is final height of boys and girls established?
99% of final height is established at
- bone age 15 in girls
- bone age 17 in boys
What is one of the most common causes of central precocious puberty?
Hypothalamic hamartoma
Causes of peripheral precocious puberty in females and males
Females
- McCune Albright syndrome
- Adrenal tumour
- Primary hypothyroidism (TSH acts on FSH receptor)
- Exogenous estrogen (BCPs)
- Ovarian tumor/cyst

Males
- CAH
- hCG secreting dysgerminoma/hepatoma
- Anabolic steroids
- Testicular tumour
- Testotoxicosis
- Adrenal tumour
What is the treatment for central precocious puberty?
DepoProvera - for girls

GnRH agonist (Leuprolide) - boys and girls
- not recommended in girls who begin puberty at 6-8, with slow progression and/or acceptable predicted adult height
What is the management of the delayed puberty in CDGA (constitutional delay of growth and adolescence)?
Treatment is never initiated before age 13.

Boys - watchful waiting. Can give 6 mo course of low dose depot testosterone to kick-start puberty.

Girls - watchful waiting. Can give ethinyl estradiol. Even more hesitant to treat, because EE is potent at closing growth plate - generally, will not treat girls.
What is the most important immediate investigation of anorexia nervosa?
Most important investigation for immediate health is ECG, because they often have QT interval prolongation
What is the most common metabolic derangement in bulimia nervosa?
Hypochloremic hypokalemic metabolic alkalosis
What is involved in an IPS (integrated prenatal screen)?
Nuchal translucency
PAPP-A
Quad screen
- AFP
- hCG
- uE3
- Inhibin A

Note that PAPP-A and NT are done in 1st trimester, and the rest are done in 2nd trimester
When is routine prenatal ultrasound usually done?
18-20 weeks GA
What is the time window for doing amniocentesis? CVS?
Amnio: 15-17 weeks GA
CVS: 10-12 weeks GA
What is the background risk of birth defect or mental retardation for each pregnancy?
3-5% risk
What is a cystic hygroma?
Congenital lymphatic cyst in posterior triangle of neck. If seen on prenatal ultrasound, it is associated with risk of Turner syndrome.
What genes are needed to develop the gonads from the urogenital ridge?
WT1, SF-1, DAX1
What is the SRY portion of the Y chromosome required for? What is the long arm of the Y chromosome important for?
SRY, on Yp (short arm) - needed for testis formation.

Yq (long arm) - needed for spermatogenesis.
What induces formation of Wolffian duct structures?
What induces formation of external genitalia?
Wolffian duct structures - testosterone

External genitalia - DHT
What are the remnants of the Mullerian ducts in male adults?

of the Wolffian duct in female adults?
Mullerian duct remnants:
- Utriculus prostaticus
- Appendix testis

Wolffian duct remnants:
- Paroophoron
- Epoophoron
- Gartner's cyst
What are derivatives of the Mullerian duct in females?
Fallopian tubes
Uterus
Upper 2/3 of vagina
What is mixed gonadal dysgenesis?
What is pure gonadal dysgenesis?
Mixed gonadal dysgenesis: 45X / 46,XY mosaicism

Pure gonadal dysgenesis: many variations, but one form is 46,XY with deletion of SRY region
What is the clinical picture of a person with pure gonadal dysgenesis?
46XY with SRY deletion
• Unambiguous females with streak gonads (therefore no menses)
• Have Mullerian duct derivatives (because no MIS)
What are the different categories of congenital anomalies?
1. Malformations (cleft lip, palate)
2. Disruption (porencephaly)
3. Deformation (plagiocephaly)
What symptoms/signs would you see with zinc deficiency?
Weak sense of taste and smell
Hypogonadism
Immune dysfunction
Marked growth reduction
Night blindness
Dry skin on palms and soles (acrodermatitis)
What is marasmus?
It is deficiency in energy providing foods

Clinical presentation
□ Infant looks wasted, like an old person
□ Child is weak, hypotonic, and cold
□ Hair loss and loose baggy skin
What is phenylketonuria, and what serious effect does it have?
Deficiency in phenylalanine hydroxylase in liver.

Phenylalanine accumulation in blood and tissues causes serious effect on brain function (intellectual disability)
What are some drugs that are "anti-vitamin"?
Trimethoprim affects folic acid
Anti-TB drugs antagonize B6
What are the stages of fetal lung development, and when do they occur?

Which is the stage when postnatal survival becomes a possibility?
• Pseudoglandular - 5-17 weeks
• Canalicular - 16-25 weeks
• Saccular - 24 weeks - term
• Alveolar - late pregnancy throughout infancy

Saccular stage is when survival is possible.
How much fetal lung fluid is formed per day at term?
Up to 400 ml / day
What is pulmonary surfactant made of?
90% lipid (dipalmitoyl phosphatidylcholine)

10% protein - SP-A, SP-B, SP-C, SP-D
• A and D - immunity
-Deficiency causes susceptibility to respiratory infections
• B and C - help spread surfactant over the surface
-Deficiency causes refractoriness to treatment with exogenous surfactant
What are the three most common causes of neonatal respiratory distress?
1. Transient tachypnea of the newborn
-FLF still present in lungs
-On x-ray, lungs seem overinflated, and there is prominence of cardiac silhouette

2. Respiratory distress syndrome
-Lack of pulmonary surfactant production/release
-Mostly a problem of pre-term infants
-On x-ray, low lung volume, and there is loss of cardiac silhouette

3. Meconium aspiration syndrome
-Mostly seen in post-term babies
-On x-ray, hyperinflation, areas of emphysema, atelectasis and pleural effusions
When can cow's milk be introduced into an infant's diet?
What is the maximum intake of milk at this time?
After 12 months.
After 1 year, max intake of milk should not exceed 24 oz per day.
Name the primitive reflexes, and when they should disappear.

Same with postural reflexes, and when they should appear.
Primitive reflexes
- Stepping, 2 mo
- Moro, 4 mo
- Galant, 6 mo
- Palmar, 6 mo
- Plantar, 7 mo
- Rooting/sucking, persist as voluntary feeding

Postural reflexes
- Protective equilibrium, 4-6 mo
- Parachute, 8-9 mo
What are the most common infectious agents that cause early onset postnatal sepsis? late onset?
Early onset:
-GBS
-Listeria
-E. coli
-Enterovirus

Late onset:
-Any of the above, PLUS
-Staph aureus
-Coagulase negative Staph
-Anaerobes
-Pseudomonas
-Candida
Postnatally, when is the period of highest susceptibility to extracellular, intracellular and encapsulated pathogens?
Extracellular (e.g. E. coli) - first 6 mo

Intracellular (e.g. CMV), and encapsulated (e.g. GBS) - first 2 years
What are the most common causes of congenital malformations?
1. Multifactorial/unknown 65%
2. Genetic 25%
3. Maternal condition 4%
4. Maternal infection 3%
5. Mechanical deformations 1-2%
6. Drugs and chemicals < 1%
What are the 5 FDA classifications for drug safety in pregnant women?
A - controlled studies in pregnant women show no risk

B - no evidence of risk in humans

C - risk cannot be ruled out

D - positive evidence of risk, but benefits may still outweigh risk

X - positive evidence of risks, which clearly outweigh the benefits
What are the main considerations in neonatal pharmacokinetics?
Higher gastric pH (i.e. more basic)
Stratum corneum is thinner
More water composition, less fat composition
Some liver enzymes are not fully expressed at birth
Lower GFR and renal tubular excretion
What is the conversion calculation for infant dosages of medications, based on dosages meant for adults?
Dose for infant = dose (for adult) * (BSA of infant / BSA of adult)

BSA = body surface area
What are characteristics of a drug that cause more of it to be excreted in breast milk?
Lipophilic
↓ Ionization
Low molecular weight
Low protein binding
Which drugs may be excreted into breast milk?
Benzodiazepines
Barbiturates
Narcotics
Anticancer drugs
Antidepressants and antipsychotics
What are the mechanisms by which thyroid hormone contributes to growth?
T3 has direct effect on osteoblasts via interaction with thyroid hormone receptor (TR).

Indirect action via permissive effect on GH and IGF synthesis and action
How does Cushing syndrome cause growth retardation?
Positive feedback on somatostatin, which inhibits GH release
Disrupt GH pulsatility
↓IGF-1 activity
↓Connective tissue synthesis

↓Adrenal gland androgen production
How many words should be in the vocabulary of a 2-3 year old?
3-4 year old?
2-3 yr: 200 words
3-4 yr: 400-1500 words
What are the daily iron requirements for age 9-13? 14-18?
Age 9-13 years: 8 mg
• Need more if in growth spurt
◊ +2.9 mg for boys
◊ +1.1 mg for girls
◊ +2.5 mg If menstruating

Age 14-18
□ Boys need 11 mg
□ Girls need 15 mg
□ Can take less (11.4 mg) if taking oral contraceptives

If vegetarian, multiply by 1.8 to correct for non-heme iron

Upper level of iron is 45 mg/day
What is the issue with taking too much zinc?
It competes with copper.
What is the treatment for the following STIs -

Chlamydia?
Neisseria gonorrheae?
Treponema pallidum?
Trichomonas vaginalis?
Scabies?
Chlamydia - tetracycline
Neisseria gonorrheae - cefixime
Treponema pallidum - penicillin G
Trichomonas vaginalis - metronidazole
Scabies - permethrin
What organisms are possible in urethritis?
What is the empiric treatment?
Chlamydia
Ureaplasma
Mycoplasma
Gonorrhea
Trichomonas

Cefixime and doxycycline
What organisms are possible in cervicitis?
What is the empiric treatment?
Gonorrhea
Chlamydia

Cefixime and doxycycline
What organisms are possible in pelvic inflammatory disease?
Gonorrhea
Chlamydia
Polymicrobial (anaerobes, gram negatives)
What organisms are possible in epididymitis?
What is the empiric treatment?
Gonorrhea
Chlamydia
UTI pathogens (E.coli)

Cefixime and doxycycline
Ciprofloxacin for UTIs
Which opioid is given for long term treatment of addiction?
Naltrexone is p.o., and long-acting.

Contrast with naloxone, which is i.v. and short-acting.