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11 Cards in this Set
- Front
- Back
3 ways Zinc acts on the immune system
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1. supports production of thymulin in thymus; stimulates production of T-cells
2. stim CD4 Tcell differentiation outside thymus (FAVORS Th1) 3. essential for Zinc-finger TFs |
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5 points for Vitamin C
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1. collagen formation (stabilize epithelial barriers)
2. Anti-oxidant (protects cell membrane; protects DNA/protein by donating electron; squelches ROS in EC space; induce apoptosis in neutrophils) 3. Pro-oxidant (produce ROS in neutrophils) 4. Reduces iron to make it easier to absorb (Fe2+) 5. Necessary to convert dopamine to NE |
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4 things for Vitamin D
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1. 1,25-OH Vit D is a TF regulating immune cells
2. favors Th2 by changing cytokine production 3. Macrophages can make activated ,25-OH Vit D 4. Stimulates macs, monocytes, epis to produce antimicrobial peptides |
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3 things for Vitamin A
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1. retinoic acid is a TF
2. acts locally because only some cells have ALDH enzyme, which makes RA active 3. RA stimulates gut dendritic cells to activate B-cells + attract T-cells to gut |
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Which vitamin stimulates IgA production in the gut?
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Vitamin A
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Supplementation of which 2 vitamins/minerals saves life in poor countries?
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Zinc + vitamin A
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Which vitamin is found only in animal products?
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B12
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What are the toxicities of Vitamin A?
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acute = nausea, vomiting, vertigo, blurred vision
chronic = alopecia, dry skin, hyperlipidemia, hepatotoxicity, HSmegaly Teratogen = microcephaly, cleft palate, cardiac anomalies, fetal death |
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How much folate should a pregnant woman take?
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600mg
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How is Vit 6 absorbed?
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passively along SI
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What vitamin is important in strengthening hair and nails?
What is the deficiency of this enzyme? |
biotin
dermatitis, alopecia, enteritis (caused by excessive ingestion of raw eggs--avidin avidly binds biotin) |