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11 Cards in this Set

  • Front
  • Back
3 ways Zinc acts on the immune system
1. supports production of thymulin in thymus; stimulates production of T-cells
2. stim CD4 Tcell differentiation outside thymus (FAVORS Th1)
3. essential for Zinc-finger TFs
5 points for Vitamin C
1. collagen formation (stabilize epithelial barriers)
2. Anti-oxidant (protects cell membrane; protects DNA/protein by donating electron; squelches ROS in EC space; induce apoptosis in neutrophils)
3. Pro-oxidant (produce ROS in neutrophils)
4. Reduces iron to make it easier to absorb (Fe2+)
5. Necessary to convert dopamine to NE
4 things for Vitamin D
1. 1,25-OH Vit D is a TF regulating immune cells
2. favors Th2 by changing cytokine production
3. Macrophages can make activated ,25-OH Vit D
4. Stimulates macs, monocytes, epis to produce antimicrobial peptides
3 things for Vitamin A
1. retinoic acid is a TF
2. acts locally because only some cells have ALDH enzyme, which makes RA active
3. RA stimulates gut dendritic cells to activate B-cells + attract T-cells to gut
Which vitamin stimulates IgA production in the gut?
Vitamin A
Supplementation of which 2 vitamins/minerals saves life in poor countries?
Zinc + vitamin A
Which vitamin is found only in animal products?
B12
What are the toxicities of Vitamin A?
acute = nausea, vomiting, vertigo, blurred vision
chronic = alopecia, dry skin, hyperlipidemia, hepatotoxicity, HSmegaly
Teratogen = microcephaly, cleft palate, cardiac anomalies, fetal death
How much folate should a pregnant woman take?
600mg
How is Vit 6 absorbed?
passively along SI
What vitamin is important in strengthening hair and nails?

What is the deficiency of this enzyme?
biotin

dermatitis, alopecia, enteritis (caused by excessive ingestion of raw eggs--avidin avidly binds biotin)