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9 Cards in this Set

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  • Back
What is MG?
Myasthenia gravis is characterized by the development of skeletal muscle weakness that may range in severity from slight interference with normal muscle strength to wide spread severe muscle weakness.
What are symptoms of MG?
1. Drooping eye lids
2. Difficulty swallowing
3. Inability to perform even a simple tasks
What causes MG?
Precise cause of MG is unknown. However, recent evidence seems to indicates that MG is resulted from damage to acetylcholine receptors at the neuromuscular junction caused by an autoimmune reaction. This damage interferes with normal nerve impulse transmission thereby reduces muscle activity.
How do we treat MG?
Therapy aimed at increasing acetylcholine at the neuromuscular junction. This is accomplished by the administration of drugs that exert an anticholinesterase action. Cholinesterase is the enzyme that destroys acetylcholine at the neuromuscular junction.
What drug is use in He treatment of MG. ?
Neostigmine (Prostigmin)
Classification of Neostigmine (Prostigmin)
a) Cholinergics (parasympathomimetics)
b) Skeletal muscle stimulant
c) Anticholinesterase
Mechanism
Neostigmine (Prostigmin)
inhibits the action of cholinesterase thereby increases acetylcholine at the neuromuscular junction.
use of
Neostigmine (Prostigmin)
treatment of myasthenia gravis.
Side/adverse effects of
Neostigmine (Prostigmin)
1) Lacrimation
2) Salivation
3) Diarrhea
4) Intestinal cramping
5) Bradycardia
6) miosis