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33 Cards in this Set
- Front
- Back
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Atorvastatin (Lipitor)
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HMG-CoA Reductase Inhibitors (statins)
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Fluvastatin (Lescol)
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HMG-CoA Reductase Inhibitors (statins)
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Lovastatin (Mevacor)
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HMG-CoA Reductase Inhibitors (statins)
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Pravastatin (Pravachol)
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HMG-CoA Reductase Inhibitors (statins)
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Rosuvastatin (Crestor)
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HMG-CoA Reductase Inhibitors (statins)
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Simvastatin (Zocor)
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HMG-CoA Reductase Inhibitors (statins)
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HMG-CoA Reductase Inhibitors (statins) effects
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decrease LDL (low density lipoprotein)
increase HDL (high density lipoprotein) decrease TG (triglycerides) -block cholesterol synthesis -anti inflammatory & anti thrombotic |
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HMG-CoA Reductase Inhibitors (statins) considerations
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-freq initial therapy for signif elevated cholesterol & LDL levels
-myopathy adverse effect -monitor hepatic function -contraindicated for liver disease |
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Niacin-extended release (Niaspan)
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Nicotinic Acids
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Niacin-intermediate release (Niacor)
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Nicotinic Acids
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Niacin-sustained release (Slo-Niacin)
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Nicotinic Acids
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Nicotinic Acids effects
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decrease LDL
increase HDL decrease TG decrease lipoprotein synthesis |
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Nicotinic Acids used for
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-may be used minimally for elevated cholesterol & LDL levels, or as an adjunct to a statin when lipid goal not achieved & TG levels are elevated
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Nicotinic Acids side effects
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flushing, hyperglycemia
hyperuricemia (gout), upper GI distress heptoxicity |
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Nicotinic Acids other considerations
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monitor hepatic function
containdicted in gout & liver failure dose needs to be titrated weekly to achieve therapeutic dosage |
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Fenofibrate (TriCor)
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Fibric Acids (fibrates)
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Gemfibrozil (Lopid)
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Fibric Acids (fibrates)
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Fibric Acids (fibrates) effects
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increase HDL
decrease TG decrease cholesterol synthesis |
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Fibric Acids (fibrates) side effects
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dyspepsia, gallstones, myopathy
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Fibric Acids (fibrates) other considerations
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-contraindicted in severe renal & liver disease
-have potential to increase LDL, may be used in pts w TG levels > 400mL/dL -use w caution w pts also taking a statin |
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Cholestyramine (Questran)
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Bile Acid Sequestrants
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Colestipol (Colestid)
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Bile Acid Sequestrants
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Bile Acid Sequestrants effects
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decrease LDL
slight increase HDL bind cholesterol & increase its breakdown |
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Bile Acid Sequestrants use
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most often used as adjunct therapy when statins alone not effective in controlling lipid levels & TG levels < 200mg/dL
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Bile Acid Sequestrants side effects
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GI distress
constipation decreased absorption of other drugs |
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Ezetimibe (Zetia)
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Cholesterol Absorption Inhibitor
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Cholesterol Absorption Inhibitor effects
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decrease LDL
increase HDL decrease TG |
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Cholesterol Absorption Inhibitor considerations
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-better tolerated than bile acid seq
-may be used in combination w other agents such as statins |
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Cholesterol Absorption Inhibitor side effects
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back pain, arthralgia (joint pain), & abdominal pain
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Fish oil capsules
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Omega-3-Acid-Ethyl Esters
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Omega-3-Acid-Ethyl Esters effects
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decrease TG
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Omega-3-Acid-Ethyl Esters considerations
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-may be used alone or in combination w other agents
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Omega-3-Acid-Ethyl Esters side effects
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taste perversion, rash, flu, back pain
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