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33 Cards in this Set

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Atorvastatin (Lipitor)
HMG-CoA Reductase Inhibitors (statins)
Fluvastatin (Lescol)
HMG-CoA Reductase Inhibitors (statins)
Lovastatin (Mevacor)
HMG-CoA Reductase Inhibitors (statins)
Pravastatin (Pravachol)
HMG-CoA Reductase Inhibitors (statins)
Rosuvastatin (Crestor)
HMG-CoA Reductase Inhibitors (statins)
Simvastatin (Zocor)
HMG-CoA Reductase Inhibitors (statins)
HMG-CoA Reductase Inhibitors (statins) effects
decrease LDL (low density lipoprotein)
increase HDL (high density lipoprotein)
decrease TG (triglycerides)
-block cholesterol synthesis
-anti inflammatory & anti thrombotic
HMG-CoA Reductase Inhibitors (statins) considerations
-freq initial therapy for signif elevated cholesterol & LDL levels
-myopathy adverse effect
-monitor hepatic function
-contraindicated for liver disease
Niacin-extended release (Niaspan)
Nicotinic Acids
Niacin-intermediate release (Niacor)
Nicotinic Acids
Niacin-sustained release (Slo-Niacin)
Nicotinic Acids
Nicotinic Acids effects
decrease LDL
increase HDL
decrease TG
decrease lipoprotein synthesis
Nicotinic Acids used for
-may be used minimally for elevated cholesterol & LDL levels, or as an adjunct to a statin when lipid goal not achieved & TG levels are elevated
Nicotinic Acids side effects
flushing, hyperglycemia
hyperuricemia (gout), upper GI distress
heptoxicity
Nicotinic Acids other considerations
monitor hepatic function
containdicted in gout & liver failure
dose needs to be titrated weekly to achieve therapeutic dosage
Fenofibrate (TriCor)
Fibric Acids (fibrates)
Gemfibrozil (Lopid)
Fibric Acids (fibrates)
Fibric Acids (fibrates) effects
increase HDL
decrease TG
decrease cholesterol synthesis
Fibric Acids (fibrates) side effects
dyspepsia, gallstones, myopathy
Fibric Acids (fibrates) other considerations
-contraindicted in severe renal & liver disease
-have potential to increase LDL, may be used in pts w TG levels > 400mL/dL
-use w caution w pts also taking a statin
Cholestyramine (Questran)
Bile Acid Sequestrants
Colestipol (Colestid)
Bile Acid Sequestrants
Bile Acid Sequestrants effects
decrease LDL
slight increase HDL
bind cholesterol & increase its breakdown
Bile Acid Sequestrants use
most often used as adjunct therapy when statins alone not effective in controlling lipid levels & TG levels < 200mg/dL
Bile Acid Sequestrants side effects
GI distress
constipation
decreased absorption of other drugs
Ezetimibe (Zetia)
Cholesterol Absorption Inhibitor
Cholesterol Absorption Inhibitor effects
decrease LDL
increase HDL
decrease TG
Cholesterol Absorption Inhibitor considerations
-better tolerated than bile acid seq
-may be used in combination w other agents such as statins
Cholesterol Absorption Inhibitor side effects
back pain, arthralgia (joint pain), & abdominal pain
Fish oil capsules
Omega-3-Acid-Ethyl Esters
Omega-3-Acid-Ethyl Esters effects
decrease TG
Omega-3-Acid-Ethyl Esters considerations
-may be used alone or in combination w other agents
Omega-3-Acid-Ethyl Esters side effects
taste perversion, rash, flu, back pain