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243 Cards in this Set
- Front
- Back
What is the pharm class of Albuterol (Proventil)?
|
Adrenergic: Selective short-acting beta 2 agonist
|
|
What is the therapeutic class of Albuterol (Proventil)?
|
bronchodilator
|
|
What is the pharm class of Salmeterol (Serevent)?
|
Adrenergic: Selective long-acting beta 2 agonist
|
|
What is the therapeutic class of Salmeterol (Serevent)?
|
bronchodilator
|
|
What is the pharm class of Short-acting theophylline (Aminophylline)?
|
xanthine
|
|
What is the therapeutic class of short-acting theophylline (Aminophylline)?
|
bronchodilator
|
|
What is the pharm class of Fluticasone (Flonase)?
|
corticosteroid
|
|
What is the pharm class of Montelukast (Singulair)?
|
leukotriene antagonist
|
|
What is the therapeutic class of Montelukast (Singulair)?
|
bronchodilator
|
|
What is the therapeutic class of Diphenhydramine (Benadryl)?
|
antihistamine
antitussive |
|
What is the pharm class of Promethazine (Phenergan)?
|
phenothaizine
|
|
What is the therapeutic class of Promethazine (Phenergan)?
|
antihistamine
antiemetic sedative/hypnotic |
|
What is the pharm class of Cetrizine (Zyrtec)?
|
piperazine: peripherally selective
|
|
What is the therapeutic class of Cetrizine (Zyrtec)?
|
antihistamine
|
|
What is the pharm class of Phenylephrine (Neo-Synephrine)?
|
adrenergic vasopressor
|
|
What is the therapeutic class of Phenylephrine (Neo-Syneprine)?
|
vasopressor
|
|
What is the therapeutic class of Guaifenesin (Robitussin)?
|
expectorant
|
|
What is the therapeutic class of Acetylcysteine (Mucomyst)?
|
mucolytic
antidote for acetaminophen toxicity |
|
What is the pharm class of Aluminum hydroxide/magnesium hydroxide (Maalox)?
|
antacid
|
|
What is the therapeutic class of alum hydroxide/magnesium hydroxide (Maalox)?
|
anti-ulcer agent
|
|
What is the pharm class of Famotidine (Pepcid)?
|
histamine H2 antagonist
|
|
What is the therapeutic class of Famotidine (Pepcid)?
|
anti-ulcer agent
|
|
What is the pharm class of Omeprazole (Prilosec)?
|
proton pump inhibitor
|
|
What is the therapeutic class of Omeprazole (Prilosec)?
|
anti-ulcer agent
|
|
What is the pharm class of Misoprostol (Cytotec)?
|
prostaglandin
|
|
What is the therapeutic class of Misoprostol (Cytotec)?
|
anti-ulcer agent
abortifacient |
|
What is the pharm class of sucralfate (Carafate)?
|
GI protectant
|
|
What is the therapeutic class of Sucralfate (Carafate)?
|
GERD medication
anti-ulcer agent |
|
What is the pharm class of Bismuth subsalicylate (Pepto-Bismol)?
|
adsorbent
|
|
What is the therapeutic class of bismuth subsalicylate (Pepto-Bismol)?
|
antidiarrheal
anti-ulcer |
|
What is the pharm class of Psyilium (Metamucil)?
|
bulk forming agent
|
|
What is the therapeutic class of Psyilium (Metamucil)?
|
laxative
|
|
What is the pharm class of Docusate sodium (Colace)?
|
stool softener
|
|
What is the therapeutic class of docusat sodium (Colace)?
|
laxative
|
|
What is the pharm class of magnesium citrate?
|
saline
|
|
What is the therapeutic class of magnesium citrate?
|
laxative
|
|
What is the pharm class of Bisacodyl (Dulcolax)?
|
stimulant laxative
|
|
What is the pharm class of Lactulose (Cephulac)?
|
osmotic
|
|
What is the therapeutic class of Lactulose (Cephulac)?
|
laxative
|
|
What is the pharm class of Diphenoxylate/atropine (Lomotil)?
|
anticholinergic
|
|
What is the therapeutic class of Diphenoxylate/atropine (Lomotil)?
|
antidiarrheal
|
|
What is the pharm class of Cholestryramine (Questran)?
|
bile acid sequestrate
|
|
What is the therapeutic class of Cholestryramine (Questran)?
|
lipid-lowering agent
|
|
Wat is the therapeutic class of Metronidazole (Flagyl)?
|
anti-infective
anti-protozoal anti-ulcer |
|
What is the pharm class of Ondansetron (Zofran)?
|
5 HT3 antagonist
|
|
What is the therapeutic class of Ondasetron (Zofran)?
|
antiemetic
|
|
What is the pharm class of Scopolamine?
|
anticholinergic
|
|
What is the therapeutic class of Scopolamine?
|
antiemetic
|
|
chronic reactive airway disease characterized by bronchoconstriction, inflammation, and hyperactivity of the airways
reversible in early stages of disease |
asthma
|
|
What are the 2 major types of drugs that treat asthma and COPD?
|
bronchodilators
anti-inflammatory drugs |
|
What are the goals of asthma therapy, according to the NAEPP?
|
1. Minimal or no chronic symptoms day or night
2. Minimal or no exacerbations 3. No limitations on activities; for children, no school/parent's work missed 4. Minimal use of short-acting inhaled beta 2 agonists (<1 time per day, <1 canister per month) 5. Minimal or no adverse effects from medication |
|
How do bronchodilating drugs work?
|
they stimulate beta 2 adrenergic receptors in the smooth muscle of the bronchi, producing bronchodilation
|
|
What type of beta agonist is epineprhine?
|
non-selective (this means it hits beta 1 and 2...causing increased cardiac rate and force of contraction)
|
|
What is the toxic blood level of theophylline (aminophylline)?
|
20 mcg/mL
|
|
What are the first signs of theophylline (aminophylline) toxicity?
|
ventricular dysrhythmias
seizure coma |
|
What are the drug interactions with theophylline?
|
Nicotine and Phenytoin may decrease effectiveness.
Fluoroquinolones (anti-biotics) may lead to toxicity. |
|
type of anti-inflammatory drug used to treat asthma that stablizies the mast cells and prevents the release of inflammatory substances
|
mast cell stablizer (inhaled drug)
|
|
once a day pill given in the evening for asthma
really helps other bronchodilators work |
Montelukast (Singulair)
|
|
How should patients taking a nasal decongestant and Flonase take their meds?
|
They should take decongestant 5-15 min before Flonase spray.
|
|
What is the green zone of peak flow monitoring?
|
80-100% of personal best
|
|
What is the yellow zone of peak flow monitoring?
|
50-80% of personal best
(check triggers and start monitoring more often to see where you'll go from there) |
|
What is the red zone of peak flow monitoring?
|
50% or less of personal best
(neede to be seen by a practitioner) |
|
Are antiasthmatic drugs usually given alone or in combination?
|
in combination - know the type and purpose of each drug!
|
|
Every type of anti-asthmatic drug except _____________ should be taken on a regular schedule and continued even when symptom free.
|
short-acting, inhaled bronchodilators (ex. albuterol)
|
|
When an asthma attack occurs, the only fast-acting commonly used medication is:
|
an inhaled, short-acting bronchodilator (ex. albuterol)
|
|
A common cause of acute asthma attacks is:
|
not taking medications correctly (b/c of long-term use, expense, and adverse effects)
|
|
What can asthmatics do to help thin secretions in the throat and lungs, making them easier to remove?
|
drink 2-3 quarts of fluid a day
|
|
Asthmatics should avoid excessive intake of ____________ because they may increase HR and cause palpitations, nervousness, and insomnia.
|
caffeine-containing fluids such as coffee, tea, and cola
|
|
Do not use __________ more often than every 12 hours.
|
Salmeterol (Serevent)
|
|
a chemical mediator released in immune/inflammatory responses
located in mast cells and basophils discharged in allergic reactions, cellular injury, and extreme cold |
histamine
|
|
Which histamine receptor is involved in the contraction of smooth muscle in the bronchi and bronchioles (bronchoconstriction and respiratory distress)
|
H1
|
|
Which histamine receptor stimulates the vagus nerve endings to produce reflex bronchoconstriction and cough?
|
H1
|
|
Which histamine receptor causes increased permeability of veins and capillaries, which allows fluid to flow into sub-cutaneous tissues and form edema?
|
H1
|
|
Which histamine receptor causes increased secretion of mucous glands?
|
H1
|
|
Which histamine receptor stimulates the sensory peripheral nerve endings to cause pain and pruritus?
|
H1
|
|
Which histamine receptor causes dilation of capillaries in the skin, to cause flushing?
|
H1
|
|
Which histamine receptor causes increased secretion of gastric acid and pepsin?
|
H2
|
|
Which histamine receptor causes increased rate and force of myocardial contraction?
|
H2
|
|
Which histamine receptor causes decreased immunologic and proinflammatory reactions?
|
H2
|
|
immediate type of allergic reaction
occurs within minutes occurs with a second or later exposure to an antigen ex. anaphylaxis |
Type I
|
|
cell membrane dependent type of allergic reaction
includes drug and blood reactions ex. blood transfusion reaction |
Type II
|
|
allergic reaction characterized by the formation of antigen-antibody complexes
ex. serum sickness |
Type III
|
|
type of allergic reaction that occurs several hours or days after exposure to an antigen
ex. contact dermatitis, also happens with some antibiotics |
Type IV
|
|
immediate life-threatening allergic reaction that occurs on FIRST exposure to agent
is not an antigen-antibody reaction |
pseudoallergic drug reaction
|
|
What is the most common cause of pseudoallergic drug reactions?
|
radioopaque dyes (ex. cardiac cath or IVP)
|
|
How does an antihistamine work?
|
it occupies the same receptor sites as histamine
does NOT prevent or reduce the amount of histamine being released |
|
Are first generation H1 receptor antagonists:
selective or nonselective? sedating or nonsedating? |
nonselective
sedating |
|
Who is Benadryl contraindicated in?
|
older adults (Beer's list)
people already taking anticholingergic drugs |
|
What are the indications for Benadryl?
|
anaphylaxis
allergic rhinitis allergic dermatoses dystonic reactions nighttime sedation prevention of motion sickness |
|
a list of drugs in which the risks outweigh the benefits for use in older adults
|
Beer's list
|
|
Is Promethazine (Phenergan) on the Beer's list?
|
yes (it is first generation H1 receptor antagonist)
|
|
Are second generation H1 receptor antagonists:
selective or nonselective? sedating or nonsedating? |
selective (for H1)
nonsedating |
|
Why are second generation H1 receptor antagonists nonsedating?
|
they do NOT cross the blood brain barrier
|
|
Is Cetrizine (Zyrtec) on the Beer's list?
|
NO!
(2nd generation H1 receptor antagonist) |
|
What are some potential adverse effects of 1st generation H1 receptor antagonists IN CHILDREN?
|
drowsiness
paradoxical excitement OD may cause hallucinations, convulsions, death! |
|
What are some potential adverse effects of 1st generation H1 receptor antagonists in OLDER ADULTS?
|
confusion
dizziness hypotension sedation syncope unsteady gait paradoxical CNS stimulation anticholinergic effects |
|
Do NOT take Benadryl if you have:
|
active asthma, bronchitis, or pneumonia (b/c Benadry thickens respiratory tract secretions and makes them more difficult to remove)
|
|
With what group of drugs should you avoid prolonged exposure to the sunlight?
|
antihistamines (they may increase risk of sunburn)
|
|
drugs used to relieve nasal obstruction and discharge
most often adrenergic |
nasal decongestants
|
|
What are the contraindications to taking nasal decongestants?
|
CVD
HTN DM glaucoma MAOIs |
|
Nasal decongestant sprays should not be used for longer than:
|
3 days
|
|
drugs that supress a cough by depressing the cough center in the brain or the cough recpetors in the throat, trachea, and lungs
|
antitussive
|
|
What are the 3 types of antitussive drugs?
|
narcotic (act on the central cough center)
non-narcotic (act on peripheral cough receptors) locally acting (throat lozenges and cough drops) |
|
What kind of cough should antitussives be used for?
|
dry, hacking, nonproductive cough that interferes with rest and sleep
|
|
drugs that liquefy respiratory secretions while being formed for easier removal
|
expectorants
|
|
drugs that liquefy mucous after formation
given by inhalation |
mucolytics
|
|
With antitussive sprays, throat lozenges, and cough drops, what should you tell your patient?
|
Drink a glass of water after taking medicine to move it out of the throat and into the body.
|
|
Who is Guaifenesin (Robitussin) contraindicated in?
|
alcoholics (it contains alcohol)
diabetics (it contains sugar) |
|
What is the inhaled form of Acetylcysteine (Mucomyst) used for?
What is the oral form of Acetylcysteine (Mucomyst) used for? |
inhaled - mucolytic
oral - given for an acetaminophen (Tylenol) overdose |
|
Do not give products containing ______ or _______ to children under 18.
|
ASA
salicylates |
|
Digestive system drugs primarily alter what 3 things?
|
secretion
absorption motility |
|
alkaline drugs that neutralize gastric acids
change pH, but don't block secretion |
antacids
|
|
Magnesium-based antacids are contraindicated in:
|
renal failure
|
|
Aluminum-based antacids cause what adverse effect:
|
constipation
|
|
Magnesium-based antacids cause what adverse effects:
|
diarrhea
hypermagnesemia |
|
drugs that inhibit basal and stimulated secretion of gastric acid
|
histamine 2 receptor antagonists
|
|
What is another indication for Famotidine (Pepcid) besides peptic ulcer disease, GERD, and GI bleeding?
|
urticaria (hives) b/c Pepcid also has some effect on H1 receptor sitess
|
|
drug of choice for treatment of GERD/ulcers/GI bleed
binds to the gastric proton pump and inhibits response to stimulation of histamine, gastrin, and acetylcholine |
proton pump inhibitors
|
|
Omeprazole (Prilosec) should be used with caution in people with:
|
liver disease
|
|
drug that inhibits gastric acid secretion and increases mucus and bicarbonate secretion
is a synethetic prostaglandin E |
prostaglandin
ex. Misoprostol (Cytotec) |
|
Who should take Misoprostol (Cytotec)?
Who should NOT take Misoprostol (Cytotec)? |
Indicated for: client at high risk for GI ulceration/bleeding and clients taking high doses of NSAIDs
NOT indicated for: women who are pregnant (will induce abortion) |
|
type of drug that protects the lining of the stomach
doesn't change pH or amount of secretions used to prevent and treat ulcer disease |
GI protectant
ex. Sucralfate (Carafate) |
|
What drug should you give 2 hours before or after other drugs?
|
Sucralfate (Carafate)
|
|
intoxication with aspirin or one of its derivatives (treated with activated charcoal)
|
salicylate poisoning
|
|
What are the signs and symptoms of salicylate poisoning?
|
lethargy
dehydration tinnitus skin rash bleeding |
|
Who should NOT take bimuth subsalicylate (Pepto-Bismol)?
|
people allergic to aspirin
people taking alot of aspirin |
|
What are some indications for laxative use?
|
relieve constipation
prevent straining at stool after MI empty the bowel before surgery accelerate elimination of toxic substances acceleration excretion of parasites prevent intestinal absorption of ammonia |
|
What are some CONTRAindications for laxative use?
|
intestinal obstruction
fecal impaction undiagnosed abdominal pain |
|
Why is mineral oil not an oral laxative of choice in any condition?
|
because there is a risk of lipid pneumonia if it is aspirated into the lungs
|
|
What group of people are usually on laxatives?
|
clients with cancer (b/c of the constipation associated with morphine)
|
|
What groups of people should use laxatives cautiously?
|
renal failure
congestive heart failure |
|
antidiarrheal drug that is also used for the management of hypercholestermia
|
Cholestryramine (Questran)
|
|
strong antibiotic drug that is used as an anti-diarrheal agent
|
Metronidazole (Flagyl)
|
|
With what drug should you not drink alcohol during and for 3 days after?
|
Metronidazole (Flagyl)
|
|
What antidiarrheal drug blocks the absorption of other drugs in the intestine?
|
Cholestryramine (Questran)
|
|
What are contraindications to the use of antidiarrheal drugs?
|
diarrhea caused by:
toxic materials microorganisms campylobacter antibiotic-associated colitis |
|
Opiates are contraindicated in what type of diarrhea?
|
chronic
|
|
Lomotil is contraindicated in who?
|
children <2
b/c it has atropine in it |
|
type of drug that is effective in preventing/treating N/V induced by drugs, radiation, surgery, and most other stimuli
|
phenothiazines (Phenergan)
|
|
type of drug given to treat/prevent moderate to severe nausea and vomiting postoperatively and associated with chemo/radiation
|
5-HT3 receptor antagonist
|
|
What groups of people is Ondansetron good for?
|
cancer patients b/c it doesn't cause much sedation
pregnant women in 1st trimester with hyperemesis |
|
anticholinergic antiemetic drug used to treat motion sicknes and mild nausea from chemo
|
Scopolamine
|
|
What is the main thing to remember with Scopolamine?
|
wash your hands after putting patch on!!!
|
|
What is the pharm class of Dopamine (Intopin)?
|
adrenergic
|
|
What is the pharm class of Norepinephrine (Levophed)?
|
adrenergic
|
|
What is the pharm class of Dobutamine (Dobutrex)?
|
adrenergic
|
|
What is the therapeutic class of Dopamine (Intropin)?
|
positive inotropic vasopressor
|
|
What is the therapeutic class of Norepinephrine (Levophed)?
|
positive inotropic vasopressor
|
|
What is the therapeutic class of Dobutamine (Dobutrex)?
|
positive inotropic vasopressor
|
|
What is the pharm class of Captopril (Capoten)?
|
ACE inhibitor
|
|
What is the therapeutic class of Captopril (Capoten)?
|
antihypertensive
|
|
What is the pharm class of Losartan (Cozaar)?
|
Angiotensin II Receptor Antagonist (ARB)
|
|
What is the therapeutic class of Losartan (Cozaar)?
|
antihypertensive
|
|
What is the pharm class of Valsartan (Diovan)?
|
angiotensin receptor antagonist (ARB)
|
|
What is the therapeutic class of Valsartan (Diovan)?
|
angiotensin receptor antagonist (ARB)
|
|
What is the pharm class of Prazosin (Minipress)?
|
alpha1 agonist (peripherally acting)
|
|
What is the therapeutic class of Prazosin (Minipress)?
|
antihypertensive
|
|
What is the pharm class of Clonidine (Catapres)?
|
alpha2 agonist (centrally acting)
|
|
What is the therapeutic class of Clonidine (Catapres)?
|
antihypertensive
|
|
What is the pharm class of Metoprolol (Lopressor)?
|
beta blocker (cardioselective)
|
|
What is the therapeutic class of Metoprolol (Lopressor)?
|
antihypertensive
antianginal |
|
What is the pharm class of Amlodipine (Norvasc)?
|
calcium channel blocker
|
|
What is the therapeutic class of Amlodpidine (Norvasc)?
|
antihypertensive
antianginal |
|
What is the pharm class of Nicardipine (Cardene)?
|
calcium channel blocker
|
|
What is the therapeutic class of Nicardipine (Cardene)?
|
antihypertensive
antianginal |
|
What is the pharm class of Heparin?
|
antithrombotic
|
|
What is therapeutic class of Heparin?
|
anticoagulant
|
|
What is the pharm class of Enoxaparin (Lovenox)?
|
antithrombotic
low molecular weight heparin |
|
What is the therapeutic class of Enoxaparin (Lovenox)?
|
anticoagulant
|
|
What is the pharm class of Bivalirudin (Angiomax)?
|
thrombin inhibitor
|
|
What is the therapeutic class of Bivalirudin (Angiomax)?
|
thrombolytic
|
|
What is the pharm class of Warfarin (Coumadin)?
|
coumarin
|
|
What is the therapeutic class of Warfarin (Coumadin)?
|
anticoagulant
|
|
What is the pharm class of Aspirin (ASA, Bufferin)?
|
salicylate
|
|
What is the therapeutic class of aspirin (ASA, Bufferin)?
|
antiplatelet
|
|
What is the pharm class of Clopidogrel (Plavix)?
|
platelet aggregation inhibitor
|
|
What is the therapeutic class of Clopidogrel (Plavix)?
|
antiplatelet
|
|
What is the pharm class of Alteplase (Activase)?
|
plasminogen activator
|
|
What is the therapeutic class of Alteplase (Activase)?
|
thrombolytic
|
|
What is the pharm class of Drotecogin alfa (Xigris)?
|
activated protein C
|
|
What is the therapeutic class of Drotecogin alfa (Xigris)?
|
anti-infective
thrombolytic |
|
What is the pharm class of Atorvastatin (Lipitor)?
|
Hmg-CoA reducase inhibitor
|
|
What is the therapeutic class of Atorvstatin (Lipitor)?
|
lipid lowering agent
|
|
What is the pharm class of Fenofibrate (Tricor)?
|
fibric acid derivative
|
|
What is the therapeutic class of Fenofibrate (Tricor)?
|
lipid lowering agent
|
|
What is the pharm class of Niacin (Nia-bid)?
|
water soluble vitamin
|
|
What is the therapeutic class of Niacin (Nia-bid)?
|
lipid lowering agent
|
|
What is the pharm class of Ezetimibe (Zetia)?
|
cholesterol absorption inhibitor
|
|
What is the therapeutic class of Ezetiibe (Zetia)?
|
lipid-lowering agent
|
|
What are some general s/s of shock?
|
hypotension
tachycardia cool, clammy skin diaphoresis pallor oliguria |
|
What are the CI for giving hypotension and shock related drugs?
|
unstable dysrhythmias
cardiogenic shock after MI |
|
What are some adverse effects of drugs that treat hypotension and shock?
|
arrhythmias
hypertension tissue necrosis with extravasation palpitations chest pain |
|
What is the only drug indicated for cardiogenic shock?
|
Dobutamine (Dobutrex)
|
|
The more the fibers in the heart are stretched, the greater their force of contraction...but only to a point.
|
Starling's Law
|
|
What are the only drugs proven to improve post-MI survival?
|
ACE inhibitors
ex. Captopril (Capoten) |
|
What drugs should diabetics take to protect their kidneys from damage?
|
ACE inhibitors
ex. Captopril (Capoten) |
|
What are the main adverse effects of ACE inhibitors?
|
hyperkalemia
dry, nonproductive cough angioedema |
|
What is the advantage of taking ARBs instead of ACE inhibitors to control HTN?
|
ARBs are less likely to cause hyperkalemia or persistent cough.
|
|
When activated, alpha 1 & 2 receptors produce:
This means that alpha 1 & 2 blockers produce: |
vasoconstriction
vasodilation |
|
When activated, alpha 1 receptors produce:
This means that alpha 1 blockers produce: |
increased contractility of the heart
decreased contractility of the heart |
|
When activated, beta 1 receptors produce:
This means that beta 1 blockers produce: |
increased contractility, heart rate, and conduction
decreased contractility, heart rate, and conduction |
|
When activated, beta 2 receptors produce:
This means that beta 2 blockers produce: |
vasodilation and bronchodilation
vasoconstriction and bronchoconstriction |
|
When activated, alpha 1 & 2 receptors produce:
This means that alpha 1 & 2 blockers produce: |
vasoconstriction
vasodilation |
|
When activated, alpha 1 receptors produce:
This means that alpha 1 blockers produce: |
increased contractility of the heart
decreased contractility of the heart |
|
When activated, beta 1 receptors produce:
This means that beta 1 blockers produce: |
increased contractility, heart rate, and conduction
decreased contractility, heart rate, and conduction |
|
When activated, beta 2 receptors produce:
This means that beta 2 blockers produce: |
vasodilation and bronchodilation
vasoconstriction and bronchoconstriction |
|
What is the important AE to remember about Prazosin (Minipress)?
|
first dose phenomenon - should give first time at night
|
|
What is the most important AE to remember about Clonidine (Catapres)?
|
orthostatic hypotension
*also causes withdrawal phenomenon (rebound hypertension) |
|
Is Clonidine (Catapres) on the Beer's list?
|
yes - because of the risk of orthostatic hypotension
|
|
What are the CI of taking Metoprolol (Lopressor)?
|
bradycardia
heart block asthma |
|
What are the other indications for taking calcium channel blockers besides hypertension?
|
angina
dysrhythmias |
|
What are some causes of venous thrombosis?
|
impaired outflow of venous blood
decreased activity thrombophlebitis venous stasis |
|
What is the main AE of anticoagulant drugs?
|
bleeding
|
|
What are the important lab tests that go along with anticoagulant drugs?
|
PT/INR
aPTT LFT - liver function test Platelets |
|
What are the CI of taking anticoagulants?
|
active bleeding, except for DIC
bleeding disorders blood dyscrasias ulcers liver and kidney disease spinal cord/brain injuries |
|
What is important to remember about IV Heparin?
|
it acts immediately and must be given on IV infusion pump
|
|
What aPTT is expected when taking heparin?
|
1.5 to 2.5 what is normal
|
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What is the antidote for Heparin?
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Protamine sulfate
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What is the anticoagulant drug of choice for pregnancy and breast feeding?
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Heparin
|
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What route is Enoxaparin (Lovenox) given?
|
sub-Q
|
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What is the most commonly used oral anticoagulant?
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Warfarin (Coumadin)
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How long does it take for Warfarin (Coumadin) to start working?
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3-5 days
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What is the important lab value that you must monitor with Warfarin (Coumadin)?
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PT/INR - should be between 2 and 3
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What is the antidote for Warfarin (Coumadin)?
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Vitamin K
|
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Which drug has a high potential for food and drug interactions?
|
Warfarin (Coumadin)
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What is the reversal agent for Alteplase (Activase)?
|
Aminocaproic acid (Amicar)
|
|
What is the indicataion for Drotecogin alfa (Xigris)?
|
reduce mortality in adult patients with sepsis
|
|
Which thrombolytic drug has a short half-life (25 min)?
|
Bivalirudin (Angiomax)
|
|
What are some medications that raise LDL and lower HDL?
|
beta blockers
oral estrogens glucocorticoids thiazide diuretics drugs for HIV |
|
Which lipid-lowering drug should be given at night?
|
Atrovastatin (Lipitor)
...because cholesterol is made at night by the body |
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Which lipid-lowering drug is proven to reduce the risk of CAD and death from CVD?
|
Atrovastatin (Lipitor)
|
|
What are the adverse effects of Atrovastatin (Lipitor)?
|
rhabdomyolysis
myopathy hepatotoxicity |
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What is the most widely used and most effective lipid lowering drug?
|
Atrovastatin (Lipitor)
|
|
What is the most effective drug for reducing triglycerides and increasing HDL?
|
Fenofibrate (Tricor)
|
|
Don't mix ___________ with Atrovastatin (Lipitor) because it will cause severe myopathy.
|
Fenofibrate (Tricor)
|
|
With what lipid lowering drugs should you give other drugs at least 1 hour before or 4 hours after?
|
Cholestryramine (Questran)
|
|
What lipid lowering drug may be combined with statin to further reduce LDL?
|
Cholestryramine (Questran)
|
|
What are the main adverse effects of Cholestryramine (Questran)?
|
GI discomfort
constipation gallstones |
|
What is the most effective drug for increasing HDL?
|
Niacin (Nicotinic Acid)
|
|
What lipid lowering drug requires high doses to be given?
|
Niacin (Nicotinic acid)
|
|
What are the AE of Niacin (Nicotinic acid)?
|
skin flushing
pruritus gastric irritation |
|
____________ can be given 1/2 hour before giving Niacin (Nicotinic acid) to decrease ____________.
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ASA (aspirin)
flushing |
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What lipid lowering drug blocks absorption of cholesterol from the gut?
|
Ezetimibe (Zetia)
|