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7 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Bone is make up of what 2 major compounds?
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Calcium phosphate and Calcium Carbonate
Together what are these referred to? |
Hydroxyapatites
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__________ build up bone and __________break it down and __________are mature cells
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Osteoblasts build up bone and osteoclasts break it down and osteocytes are mature cells
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Imaging of the bone used to be done strictly with Sr and then inorganic phosphates, What type of bond was that and what has it been replaced with and why?
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It was a phosphate-Oxygen-phosphate or P-O-P bond (PYP, which is now used for red blood cell tagging). Now organic phosphates are used with a P-C-P bond, with Carbon in the middle. These are more stable.
What are the 2 main isotopes used today? |
99mTc99 HDP (hydroxymethylene diphosphonate)
99mTc99 MDP (methylene diphosphonate) |
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How does MDP and HDP localize on the bone tissue?
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It is not fully understood but there is an ion exchange with the phosphate that is especially attracted to areas of ossification
What are 2 other theories? |
1. hydroxyapatite crystals remove phosphate compounds from radiopharmaceutical in blood stream releasing the Tc and allowing it to bind to another site in hydroxyapetite crystal
2. radiopharmaceutical is taken up by collagen |
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What are the 7 clinical indications for bone scans?
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1. Staging of malignant disease
2. Rule out/confirm primary bone neoplasms 3.Diagnosis of early skeletal inflammatory disease (osteomyelitis vs. cellulitis, diskitis) 4. Evaluation of skeletal pain of undermined etiology 5. Evaluation of elevated alkaline phosphatase 6. Determination of bone viability 7. Evaluation of painful total joint prostheses |
Most Nice Indians Prefer A Volumptous Pocahantas
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What causes increased uptake, give some examples?
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any disorder which causes active bone formation, metastatic lesion, paget's disease, fracture, osteomyelitis, bone tumor, rheumatoid arthritis
What causes decreased uptake? |
Necrosis (dead area)
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What is the tell tale sign of Paget's disease?
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uptake in the vertebrae that looks like "Mickey mouse"
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