Nuclear Medicine Study Deck

Front 1

Nuclear bombardment involves the fission of what two elements?

Back 1

235U or 239 PU

Front 2

In the cyclotron v In Cyclotron – target bombardment withcharged particles (a, protons,deuterons):Ø 123I (), 18F, 67Ga(etc), 111In,201Tl (radionucleotides). What are some special roles of I123 and 67 Ga???

Back 2

I123: used in children

67Ga: neoplasms

Front 3

What type of radiation do we want from radionucleotides?

Back 3

Only y-radiation

Front 4

What is 133Xe used for?

Back 4

Lung imaging scintography

Front 5

What radionucleotide is mainly used in PET? What is the half life?

Back 5

F18. 110 minutes therefore must be made on site.

Front 6

What is used for figuring out the O2 demand of myocardial cells?

Back 6

O15

Front 7

What radionucleotide is used in bone metastisis treatment?

Back 7

P32

Front 8

How is 89 SR used in therapy?

Back 8

v bonemetastasis treatment (similar to Ca2+, only b-radiation)

Front 9

What is 153 Sm used for in treatment?

Back 9

Scintography and bone treatment

Front 10

186Re + 198Au . How are they used in therapy?

Back 10

treatment of infammation

Front 11

Are radiopharmaceuticals receptor binding specific?

Back 11

yes

Front 12

List some potential radiolabels for monconal anitbodies?

Back 12

Ø 131I,123I, 111Ln, 99mTc, 90Y

Front 13

PET is labelled with what and taken up by what type of cells?

Back 13

Ø Labeled with glucoseØ Taken up by rapidly dividing cells (malignant)– used for imaging of neoplasms

Front 14

List radiopharmaceuticals of non-specific affinity for neoplasm?

Back 14

v 67Gav 201Tlv 99mTc-sestamibiv 18F-FDG

Front 15

67Ga, v Secreted inbile (always a lot in the intestine – !) Therefore 67Ga cannot identify what?

Back 15

abdomen!

Front 16

201Tl chloride is an analog of what and isavidly concentrated by active, viable neoplasms due to sodium/potassium pump?

Back 16

Potassium

Front 17

99mTc-sestamibi (Technetium-99m-sestamibi):has a half life of how long and submits what type of rays?

Back 17

6 hours, y gamma(very good)

Front 18

What is 99mTC-sestamibi taken up by?

Back 18

Ø What we really see are the mitochondria inproperly working viable cells!

Front 19

What is zevalin?

Back 19

ibritumomav tiuxetal, 90Y-labeledmurine MAb to CD-20 antigen on B-cells in follicular NHL, the only widelyused monoclonal radiopharmaceutical for lymphoma therapy

Front 20

List some somatostatin analogues

Back 20

Ø 111In– pentetreotide (OctroScan)Ø 99mTc– HYNIC-DOTATATEØ 99mTc– depreotide

Front 21

List the 1/2 life and type of emission for I131.

Back 21

8 days, y and B

Front 22

1/2 life and type of emission of I123?

Back 22

v T1/2: 13 hoursv Type ofemission: g

Front 23

In radiosynarthrosis what radionucleotides are used for big joints, medium joints and small joints?

Back 23

v 90Y– colloid – big jointsv 186Re– colloid – medium size jointsv 169Er– colloid – small joints

Front 24

v Cerebrovasculardisease – – the only techiques thatmay demonstrate the perfusion deficits are?

Back 24

SpeCT and PET

Front 25

The static renal scintigraphy is indicated for assessment of:

Back 25

renal scarring in chronic pyelonephritis

Front 26

Which of the following radiopharmaceuticals is not used in dynamic renal scintigraphy?

1)99mTc-DTPA

2)99mTc-MAG3

3)99mTc-DMSA

4)All of the above radiopharmaceuticals

Back 26

1)99mTc-DTPA = 15mci=GFR

2)99mTc-MAG3=8MCi=Tubular secretion

3)99mTc-DMSA=Static

Front 27

Radionuclide imaging is contraindicated in ...

Back 27

Pregnant and lactating women.

Front 28

The most widely applied radiopharmaceutical in bone scintigraphy is ?

Back 28

99mTC methylene diphosphonate (MDP)

Front 29

When do we use Scintigraphy for thyroid cancer?

Back 29

Radiotracer: oral iodine 131 prefered, iodine 123 may be useful  2-5 mCi  max. endogenous TSH stimulation (required TSH level of 30 mcU/ml or more) - withdrawal of LT4 4-6 weeks before the scintigraphy  or recombinated human TSH administration when LT4 withdrawal is not possible  applicable only for differentiated thyroid cancer (papillary or follicular) - medullary and anaplastic carcinomas do not accumulate iodine!  Extended field of view images and whole body imaging are used

Front 30

24 hour radioactive iodine uptake may be increased by treatment with?

Back 30

lithium carbonate, pregnancy, rebound after therapy, recovery from subacute thyroiditis, choriocarcinoma, inborn errors of thyroid metabolism

Front 31

What radiopharmaceutical is used for the diagnosis of a mediastinal mass?

Back 31

1)99mTc Pertechnate (NOT APPLICABLE FOR SUBSTERNAL MASS)

2)131-I

Front 32

Bone Scintigraphy with 99mTc MDP is patients suspected a bone metastasis is an exzmination revealing?

Back 32

High sensitivity, low specificity

Front 33

What radiopharmaceutical is the indicator of GFR?

Back 33

99mTC DTPA

Front 34

Radioactive iodine is used for treatment of what thyroid cancer?

Back 34

follicular and papulary

Front 35

List 3 advantages of PET/CT.

Back 35

short transmission time,

better sensitivity in primary focus and npl recurrent detection,both anatomical and functional info is available due to image acquisition and fusion of both modilities.