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47 Cards in this Set

  • Front
  • Back
Why might a chemotherapy regimen only have a minimal effect on certain tumors?
tumor cells in resting phase (low growth fraction)
Chemotherapy is most effective against cells that are ______________.
replicating
Solid breast tumors tend to have a ____ growth fraction.
low
Extravacation may cause _______ with administration of doxorubicin (Adriamycin)
severe blistering (vesication) and extensive cellulitis or "red death"
[remember, if you "rub" your skin wrong, it will blister OR RUBy-colored blisters)
With no blood return on an IV push of doxorubicin (Adriamycin), the next step would be to...
gently and slowly flush with 20-30 mL of saline while monitoring for pain or swelling
With 3-4 weeks prolonged diarrhea, look for _____ and _____
decreased serum albumin,
reduced serum potassium
A common side effect of ciplatin (Platinol) is...
delayed n/v (24-48H p admin)
[remember "platinum" = goldschlager = delayed n/v]
ondansetron (Zofran) is..
antiemetic
[remember Zofran is similar to "suffering", stops pt from suffering from n/v]
Diphenoxylate (Lomotil), an opioid and atropine combo, is on of the most effective _____ drugs
antidiarrheal
[remember something about "tilling the loam" r/t diarrhea]
Administering fluorouracil (5-FU) and applying radiation therapy to the abdomen can cause...
significant and prolonged diarrhea
Sibutramine (Meridia) is...
an anorexiant
[remember "I'm staying at the Meridian Hotel on the beach, so I won't eat to help my figure"]
Bisacodyl (Dulcolax) is...
a laxative
Toxic effect of bleomycin (Blenoxane)...
pulmonary toxicity
(dose-related and age-related)
[BLEOmycin = BLEW = Blue(cyanosis)
OR "one blows air" (r/t breathing)]
Toxic effect of doxorubicin (Adriamycin)...
cardiotoxicity
[remember: "Adrian!"... Rocky's got a lot of heart]
Toxic effect of vincristine (Oncovin)...
neurotoxicity
[remember VINdictive CRISTIans seem to have some neurological problems]
Toxic effect of cyclophosphamide (Cytoxan)...
hemorrhagic cystitis
[the letters "cy" start both words]
The agents most likely to cuase chemotherapy related second malignancies are...
alkylating agents
The chemotherapeutic process is: (1 thru 4)
1. teaching
2. informed consent
3. physical assessment
4. administration of drugs
All chemotherapy drugs cause...
bone marrow suppression (esp. WBCs)
Normal range of neutrophils... (in %)
55-70%
Normal ranges for adult female:
Hematocrit
Hemoglobin
37%-47%
12-16 grams/dL
Normal range for platelet count...
150,000-400,000/mm3
Normal range for RBCs for adult female...
4.4-5.4 million/mm3
To help decrease diarrhea, eat...
a low residue, semi soft diet
Normal range for ANC/AGC...
2500-6500/mm3
To decrease n/v, avoid...
fatty or spicy foods
A metallic taste is a common complaint of client's receiving...
cyclophosphamide (Cytoxan)
[remember 'cylons' are made of metallic and you'd certainly get a metal taste in your mouth if you kissed one]
etoposide (VP-16) PO causes what GI side effect? (x6)
stomatitis, n/v, dyspepsia, anorexia, diarrhea, constipation
doxorubicin (Adriamycin) PO causes what GI side effects? (x5)
stomatitis, n/v, anorexia, diarrhea, esophagitis
prednisone (Deltasone) PO alters GI tract by...
enhancing n/v and peptic ulcer dev't
Normal range for WBCs...
5,000-10,000
Do not administer chemotherapy to a client who...
recently received a live virus immunization
To treat chemotherapy-induced anemia use...
epoetin (Epogen)
It is better to _____ chemotherapy-induced n/v than to treat it when it occurs
pre-treat
Antitumor hormones or hormone antagonists such as nolbadex or Megace are the most commonly associated with what adverse effect?
infertility
_____ is more commonly associated with alkylating agents such as cyclophosphamide and Leukeran.
Ototoxicity
Biologic response modifiers such as Intron A may cause encephalopathy, and clients may become... (x2)
suicidal and clinically depressed
Mechlorethamine HCL (Mustardgen) is a potent ____
vesicant
If Mechlorethamine HCL (Mustardgen) extravasates, sub q and ID injection with _____ and application of _____ may reduce local irritation.
isotonic sodium thiosulfate, ice compresses
define: nadir
period of the lowest WBC count after chemo
[remember Ralph Nader = lowest voted candidate in 2000]
Although many chemotherapy agents can cause _____, the antimetabolites are commonly known for causing this side effect.
stomatitis
_____ is a common side effect of vinca alkaloids
cardiotoxicity
["vin" French for wine is said to bet good for the heart, vinca, not so good...]
Clients often experience _______ after administration of immunostimulants (e.g. filgristam (Neupogen))
flu-like symptoms
Cyclophosphamide (Cytoxan) is _____, esp with high doses
cardiotoxic
cytarobine (Cytosar-U) has the primary side effect of...
GI bleed
["bine" as in "binds" you up]
paclitaxel (Taxol) is often infused on an inpatient setting b/c of risk of significant... (x4)
hypotension, tachycardia, bronchospasms, and chest pain
(i.e. serious cardiovascular impairment)
A client with thrombocytopenia is at high risk for...
bleeding