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36 Cards in this Set
- Front
- Back
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this pathway yields leukotrienes
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lipoxygenase
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neutrophil chemotactic agent
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LTB4
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function in bronchoconstriction, vasoconstriction, contraction of smooth muscle and increase vascular permeability
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LTC4, D4, E4
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inhibits platelet aggregation and promotes vasodilation
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PGI2
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these work by blocking phospholipase A2 and protein synethesis of COX
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corticosteroids
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work by blocking COX
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NSAIDS, tylenol, cox-2s, aspirin
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MOA of aspirin
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blocks cox and thromboxane (anti-platelet properties)
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effects of thromboxane
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increases platelet aggregation
increases vascular tone increases bronchial tone |
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effects of prostaglandins (PGE, PGF)
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decreases vascular tone
decreases bronchial tone increases uterine tone |
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effects of prostacyclin (PGI)
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decreases platelet aggregation
decreases vascular tone decreases bronchial tone decreases uterine tone |
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effects of leukotrienes
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increase bronchial tone
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blocks leuotrienes
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zafirlukast
montelukast (asthma) unsaturated fatty acids (also prostaglandins) |
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blocks lipoxygenase
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zileuton (asthma)
ketoprofen |
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how NSAIDs interact with warfarin
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displaces warfarin from albumin
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benefit of COX 2
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GI
only gets in inflammatory cells |
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MOA of colchicine
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depolymerizes microtubules (which forms the mitotic spindle), impairs leukocyte chemotaxis and degranulation
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SE of colchicine
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GI effects
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MOA of probenecid
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inhibits reabsorption of uric acid in PCT
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MOA of allopurinol
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inhibits xanthine oxidase, decreasing the conversion of xanthine to uric acid
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uses of allopurinol
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chronic gout
lymphoma/leukemia to prevent urate nephropathy |
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interactions of allopurinol
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azathioprine and 6-MP
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used in acute gout
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colchicine and indomethacin
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used in chronic gout
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probenicid and allopurinol
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contraindicated in gout
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salicylates
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MOA of etanercept
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inhibits lymphotoxin-a
binds TNF-alpha acts as a decoy and decreases cellular action of TNF-a |
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MOA of infliximab
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anti-TNF antibody
complexes with soluble TNF-a and prevents its interaction with p55 and p75 cell receptors down regulates macrophage and T cell function |
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SE of infliximab
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increased risk of infection (TB, etc)
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uses for etanercept
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RA, psoriasis, ankylosing spondylitis
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uses for infliximab
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crohn's, RA, AS
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MOA for chloroquine
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suppresses T cells to mitogens
decreases leukocyte chemotaxis stabilizes lysosomal enzymes traps free radicals |
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MOA of gold
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alters macrophages, inhibits IL-1 and reduces histamine release
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uses of gold
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RA
Sjogren's JRA |
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MOA of methotrexate
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cytotoxic to S-phase
DOC of RA |
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SE of methotrexate
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nausea and ulcers
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these drugs supress T and B cells
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cyclophosphamide and azathioprine
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MOA of cyclosporine
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inhibits IL-1,2 receptor production and macrophage T cell interacion
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