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9 Cards in this Set
- Front
- Back
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Primary MOA of NSAIDs?
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Inhibition of prostaglandin synthesis
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What are the 2 main enzymes that NSAIDs block? (1 and 2)
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COX = cyclooxygenase
COX1 and COX2, ratio of blockage varies with drug |
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4 main categories of adverse effects of NSAIDs
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1. Gastrointestinal
2. Hypersensitivity 3. Renal Impairment 4. Cardiovascular |
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General principle for treating inflammatory arthritis in terms of speed of diagnosis and aggressiveness of treatment?
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Early diagnosis and aggressive treatment! To prevent further joint damage and loss of function
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What is the major toxicity of hydroxychloroquine (Plaquneil)?
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retinopathy
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What is the major toxicities (2) of sulfasalazine?
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bone marrow suppresion (can get quick drop in WBC, so be careful about infections)
hepatic failure |
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Major toxicities (3) of methotraxate? and is it safe for pregnancy?
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bone marrow suppression, hepatitis, pneumonitis
pregancy - no |
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Major issue with biologic agents?
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cost
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What is the first line DMARD?
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methotrexate
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