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12 Cards in this Set
- Front
- Back
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Aspirin |
Only NSAID that irreversibly inhibits COX1 and COX2. Analgesic, Antipyretic, Anti-inflam, Anti-aggregate, Uricosuric. |
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Acetaminophen |
Not an anti-inflammatory. Inhibits only CNS COX. Antipyretic and Analgesic. Hepatotoxicity. Reactive metabolite depletes GSH stores and accumulates in liver. Acetylcysteine antidote supplies -SH groups to inactivate metabolite. |
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Ibuprofen |
#1 for pain relief (except ketorolac but need Rx) |
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Naproxen |
Used for gout |
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Etodolac |
Etodolac |
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Indomethacin |
Side effects thrombocytopenia, agranulocytosis |
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Ketorolac |
Strong analgesic, Rx Required |
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Nabumetone |
Nabumetone |
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Sulindac |
No renal effects, cramps, rashes, but pancreatitis |
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Tolmetin |
No effect on oral hypoglycemics. Risk to heart and stroke pts. |
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Diclofenac |
Hepatotoxicity |
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-coxib |
COX2 selective inhibitors. Rofecoxib good for arthritis. Celecoxib interact w sulphonamides. GI protective. Bad for heart bc activate COX1 and |
