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21 Cards in this Set
- Front
- Back
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Aspirin
-MOA |
hydrolyzed in blood/tissues to salicylic acid, binds to and acetylates COX1 and COX2 irreversibly inhibiting both
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Aspirin
-PK |
Readily absorbed, wide distribution including CNS
Bound to plasma proteins T1/2=3 hr low dose T1/2=15 hr high dose Urinary excretion pH dependent, increase with basic urine ex sodium bicarb PO |
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Aspirin
-Uses |
Low intensity pain, reduce fever, anti-inflammatory 325-650 mg
RA 1-4 g/day Reduce MI/Strokes 80mg/day |
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Aspirin
-AEs |
GI Sx, hypersensitivity like rxn by shunting toward leukotriene pathway, hemorrhage, acute renal/interstitial nephritis
Children @ risk for Reye's syndrome, rare but serious liver degeneration and encephalopathy |
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Aspirin
-Salicylism |
Sweating, vomitting, epigastric pain, tinnitus, blurring of vision
Early-respiratory alkalosis due to stim of respiratory centers Late-metabolic acidosis due to uncoupling of oxphos |
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Ibuprofen
-MOA/PK |
Nonspecific
Competitive inhibitor of COX1 and COX2 T1/2=2 hr PO |
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Ibuprofen
-Uses -AEs |
RA, osteoarthritis
Equal to aspirin for relief of pain Lower freq. GI irritation |
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Ketorolac (Toradol)
-MOA/PK |
Nonspecific
Comp inhibitor COX1/2 ONLY one that can be given IM (72 hours only because of risk of GI/renal damage) |
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Ketorolac (Toradol)
-Uses |
Moderate/sever pain
Analgesic=moderate dose morphine Not anti-inflammatory |
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Ketorolac (Toradol)
-AEs |
GI upset
Renal efx Risk for bleeding DONT USE BEFORE SURGERY |
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Indomethacin (Indocin)
(Sulindac-prodrug) -MOA/PK -Uses -AEs |
Nonspecific, very potent COX1/2 inhibitor
PO Moderate/sever arthritic pain Gouty arthritis, ankylosing spondylitis, osteoarthritis Greatest anti-inflammatory effect Significant GI, Sulindac less severe |
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Naproxen (Naprosyn)
-MOA/PK -Uses -AEs |
Nonspecific
PO T1/2=12-24 hr Anti-inflammatory, FDA recommends over coxibs w/proton pump inhibitor SAFEST to prevent GI irritation |
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Piroxilam (Feldene)
-MOA/PK -Uses -AEs |
Nonspecific
PO T1/2=12-24 hr LONGEST acting NSAID |
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Celecoxib (Celebrex)
-MOA/PK -Uses -AEs |
Specific COX2 block
Osteoarthritis, RA in adults Acute pain in adults Primary dysmenorrheal FAP management Headaches, increase risk for arterial thrombosis |
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Rofecoxib (Vioxx) and Vadecoxib
-MOA -AEs |
COX2 specific block
OFF MARKET cause heart block, MI, sudden death |
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Omeprazole (Prilosec)
-MOA/PK -Uses -AEs |
H+/K+ inhibitor
Decreases acid secretion Diarrhea, constipation, ab pain, headaches, longterm-stomach infxns |
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Misoprotol (Cytotec)
-MOA/PK -Uses -AEs |
PG agonist
Reduce risk of gastric and duodenal ulcers Diarrhea, abortions |
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Acetaminophen (Tylenol)
-MOA |
MOA-unknown
Metabolized in liver by p450 to toxic bensoquinone imine, inactivated by glutathione leads to liver damage PO T1/2=2-3 hr |
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Acetaminophen (Tylenol)
-Uses |
Antipyretic, analgesic, not anti-inflammatory, not NSAID, no blood thinning
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Acetaminophen (Tylenol)
-AEs |
Skin rash
Allergies Liver Damage (Rx provide free SH groups N-acetylcysteine) Drug interaxns Hepatotox w/lots of EtOH use |
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Tramadol (Ultram)
-MOA/PK -Uses -AEs |
MOA-weak opioid agonist, inhibits NE, 5-HT uptake
PO Analgesic, not anti-inflammatory, not antipyretic N/V, sweating, constipation |
