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52 Cards in this Set
- Front
- Back
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Entecavir
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HBV
NRTI, Guanosine analogue oral formulation, cross resistance with Lamivudine, resistance rate rising, nice to use in HBV patients with HIV |
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Lamivudine
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HIV, HBV
NRTI, Cytidine analogue oral formulation, high levels of resistance |
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Tenofovir
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HBV, HIV
NRTI, Adenosine analogue oral formulation, can be used when virus resistant to lamivudine and enecavir Neprhotoxicity, problems with bone metabolism |
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Zidovudine
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HIV
NRTI, Thymidine analgoue Bone marrow suppression, nausea, nail discoloration cleared by P450 |
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Cidofovir
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Cytosine analog inhibits viral DNA polymerase;
Nephrotoxic,given w/ probenecid to block renal secretion used for CMV (also maybe for adenovirus??) |
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HN attachment protein
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parainfluenza
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G attachment protein
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RSV
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NS1 secreted protein (used as diagnosis)
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Dengue fever
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G,N,L,NS/P,M proteins
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Rhabies virus
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N protein function
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Txn
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L protein fxn
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Polymerase
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NS prtein fxn
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Non structural polymerase
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M fxn
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Budding & asesembly
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CD56 receptor
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Rabies in gangliosides
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Nicotonic Receptor
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rabies
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VP proteins, NSP proteins,
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Rotavirus
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11 genomic segments
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Rotavirus
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VP4/7
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outer capsid (rotavirus)
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VP6
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Inner capsid (rotavirus)
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VP2
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CORE (rotavirus)
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VP4
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P antigen; (rotavirus)
cell attachment, hemagglutination, neutralizing epitopes |
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VP7
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Neutralizing epitopes (G Ag) (rotavirus)
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NSP4
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ER protein/assembly of ENTEROTOXIN (only known viral)
(rotavirus) |
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VP1/3
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INSIDE CORE (rotavirus)
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7 distinct serotypes (a-g)
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Rotavirus
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Serotypes in rotovirus that are dangerous to humans
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A-C
A G1/2/3/4 most important |
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3 Open Reading Frames (ORFs)
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Norovirus
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ORF1
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polyprotein for REPLICATION
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ORF2
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Structure = capside prtoein VP1
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ORF3
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VP2 unknown function
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GP120
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CD4 receptor to which HIV binds
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GP41
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CCR5 coreceptor
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Smallest Genome partially DsDNA circular
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Hep B
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P orf
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encodes polymerase (HBV)
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C ORF
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HBcAg (HBV)
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preC + C
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HBeAg
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CD46
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receptor for Measles
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V,C measles
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helps it evade immune system
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HN
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Neuraminidase (in Mumps, not measles)
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E1-E4 (HPV)
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Viral Replicating proteins
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E6-E7 (HPV)
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Oncogenic Transforming proteins
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L1 (HPV)
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VACCINE ANTIGEN
major capsid protein |
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L2 (HPV)
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Minor capsid proteins
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How many strains of HPV
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130
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Strains 16 & 18
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High risk HPV
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Strains 6 & 11
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Low Risk HPV (genital warts)
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HSV1 latency hangout
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Geniculate Ganglia
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HSV 2 latency hangout
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DRG gagnlia
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VZV latency site
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drg
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CD21
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Receptor for EBV
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UL54 protein (CMV)
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DNA polymerase
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UL97 protein (CMV)
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Kinase, phosphorylates gancyclovir
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