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35 Cards in this Set

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Alkylating Agents: Name 3
Hint: All C words
Cisplatin (Platinol)
Carboplatin (Paraplatin)

Cyclophosphamide (Cytoxan)
Alkalyting agent-is it cell cycle specific?
No It is non cell cycle specific
Cisplatin (Platinol) S.E.
SEVERE NAUSEA AND VOMITING
Renal Damage
OTOTOXICITY
Bone Marrow Depression
Neurotoxicity
Carboplatin (Paraplatin) S.E. compared to Cisplatin (Platinol)
Less N/V
Neuro/Nephro toxic,
Better therapeutic effects
Nursing Implications for Cisplatin (Platinol) and Carboplatin (Paraplatin)
Monitor the lab work closely
for bone marrow and renal damage.

Ovserve closely for hearing or renal damage

give meds to prevent/treat N/V
Cyclophosphamide S.E.
HEMORRHAGIC CYSTITIS-diffuse inflammation of the bladder leading to hemorrhage.
Bone marrow depression
N/V
alopecia
Cyclophosphamide (Cytoxan) Nursing Implications
Provide Adequate daily fluid intake to avoid hemorrhagic cystitis.
Monitor labs for bone marrow depression
Avoid pregnancy
Name the Recombinant monoclonal antibody IgG1-produced by recombinant DNA technology
Rituximab (Rituxan)
Rituximab (Rituxan) Binds to surface of normal and _______ _______ ________
normal and malignant B-Lymphocytes
Rituximab Common Side Effects
Allergic reaction
Anaphylaxis
Renal and Hepatic Toxic
Cardiac arrythmias,
TLS=Tumor Lysis syndrome
Rituximab Nursing Implications
Monitor CBC, Platelets, Liver, renal function
Monitor BP and HR
hydration and allopurinol for hyperuricemia
Name 2 Anti-Metabolite
5-Fluorouracil (5-FU)
Methotrexate (MTX)
Antimetabolites-Cell cycle affected?
Cell cycle specific for S (Synthesis phase)
5 Fluorouracil (5-FU) S.E.
ORAL AND GI ULCERATION
MUCOCITIS-Mucositis is a painful condition that significantly impairs chewing and swallowing. Previously referred to as "stomatitis" or "mouth sores," mucositis presents as redness and/or ulcerative sores in the soft tissues of the mouth. Mucositis is seen in patients with reduced white blood cell counts due to cancer chemotherapy and/or therapeutic irradiation.
N/V/D
bone marrow depression
alopecia
Methotrexate (MTX) S.E.
BONE MARROW SUPPRESSION
ULCERATIVE STOMATITIS
N/V/D
5 Fluorouracil (5-FU) N.I.
Leucovorin used with 5-FU to neutralize toxic effects and enhance therapeutic effects

Monitor labs for signs of bone marrow suppression
Monitor for oral and GI ulceration
Methotrexate (MTX) N.I.
Leucovorin is used to neutralize the toxic effects on the hematological system
USE sunscreen
Avoid pregnancy
Leucovoran Calcium (Folinic Acid) S.E.
Allergic reactions
S/S OF HYPERCALCEMIA
-LETHARGY
-HEADACHE
-WEAKNESS
-MUSCLE FLACCIDITY
-HEART BLOCK
-N/V
Leucovoran Calcium (Nursing Implications)
used to treat delayed excretion of MTX or O.D. of MTX. or as rescue after high dose of MTX therapy.
Given with 5-FU to enhance therapeutic effects and neutralize toxicities.
Name 1 Plant Alkaloid
Etoposide (VePesid) (VP-16)
Etoposide (VePesid) (VP-16) Cell Cycle Affected
G2 Phase

VP-G2
Etoposide (VePesid) (VP-16)
S.E.
Peripheral Neuropathy ***
Irritation at injection site
Alopecia
N/V
Constipation
Ulcerative Stomatitis
Etoposide N.I.
Anaphylaxis
Monitor s/s of neurotoxicity
Avoid extravasation (is a vesicant)
Stool softeners
Bone marrow suppression
Doxorubicin (Ruby-Big red)
Antibiotic
Cell Cycle Specific?
No
Non-Cell-Cycle Specific
Doxorubicin (Ruby-Big red)
Antibiotic
S.E.
Cardiac Toxicity
Irritation at injection site
Bone Marrow Depression
Nausea/Vomiting
Alopecia
Doxorubicin (Ruby-Big red)
Antibiotic N.I.
Monitor for signs of cardiotoxicity
Monitor labs
May produce red urine for 1-2 days, but it is Not Hematuria
Is a vesicant (Apply ice packs and elevate IV site)
Bleomycin (Blenoxane)
Antibiotic
Cell Cycle Specific?
yes
Cell-Cycle specific to G-2 (second growth phase)
Bleomycin (Blenoxane)
Antibiotic S.E.
PULMONARY TOXICITY
pneumonitis
Pulmonary fibrosis
N/V
Rashes
Fever
Bleomycin (Blenoxane)
Antibiotic
N.I.
Monitor Pulmonary Status closely
Paclitaxel (Taxol)
Cell Cycle Specific?
Yes
Cell Cycle specific for M (mitosis phases)
Paclitaxel (Taxol) S.E.
BONE MARROW TOXICITY
Allergic reactions
Peripheral Neuropathy
Respiratory reactions
Paclitaxel (Taxol) N.I.
Severe Neutropenia (Nadir level on day 11,
Severe thrombocytopenia (day 8-9), severe anemia
Gemcitabine Hydrochloride (Gemzar)
Cell Cycle Specific
YES
Cell Cycle Specific for S-Phase and G1 Phase
Gemcitabine Hydrochloride (Gemzar) S.E.
PULMONARY AND HEPATIC TOXICITIES
Bone marrow suppression
N/V Alopecia
Bone pain
Gemcitabine Hydrochloride (Gemzar) N.I.
Monitor CBC, liver function
Monitor pulmonary status
Treat Nausea
Treat bone pain