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35 Cards in this Set
- Front
- Back
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Alkylating Agents: Name 3
Hint: All C words |
Cisplatin (Platinol)
Carboplatin (Paraplatin) Cyclophosphamide (Cytoxan) |
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Alkalyting agent-is it cell cycle specific?
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No It is non cell cycle specific
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Cisplatin (Platinol) S.E.
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SEVERE NAUSEA AND VOMITING
Renal Damage OTOTOXICITY Bone Marrow Depression Neurotoxicity |
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Carboplatin (Paraplatin) S.E. compared to Cisplatin (Platinol)
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Less N/V
Neuro/Nephro toxic, Better therapeutic effects |
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Nursing Implications for Cisplatin (Platinol) and Carboplatin (Paraplatin)
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Monitor the lab work closely
for bone marrow and renal damage. Ovserve closely for hearing or renal damage give meds to prevent/treat N/V |
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Cyclophosphamide S.E.
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HEMORRHAGIC CYSTITIS-diffuse inflammation of the bladder leading to hemorrhage.
Bone marrow depression N/V alopecia |
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Cyclophosphamide (Cytoxan) Nursing Implications
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Provide Adequate daily fluid intake to avoid hemorrhagic cystitis.
Monitor labs for bone marrow depression Avoid pregnancy |
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Name the Recombinant monoclonal antibody IgG1-produced by recombinant DNA technology
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Rituximab (Rituxan)
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Rituximab (Rituxan) Binds to surface of normal and _______ _______ ________
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normal and malignant B-Lymphocytes
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Rituximab Common Side Effects
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Allergic reaction
Anaphylaxis Renal and Hepatic Toxic Cardiac arrythmias, TLS=Tumor Lysis syndrome |
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Rituximab Nursing Implications
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Monitor CBC, Platelets, Liver, renal function
Monitor BP and HR hydration and allopurinol for hyperuricemia |
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Name 2 Anti-Metabolite
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5-Fluorouracil (5-FU)
Methotrexate (MTX) |
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Antimetabolites-Cell cycle affected?
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Cell cycle specific for S (Synthesis phase)
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5 Fluorouracil (5-FU) S.E.
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ORAL AND GI ULCERATION
MUCOCITIS-Mucositis is a painful condition that significantly impairs chewing and swallowing. Previously referred to as "stomatitis" or "mouth sores," mucositis presents as redness and/or ulcerative sores in the soft tissues of the mouth. Mucositis is seen in patients with reduced white blood cell counts due to cancer chemotherapy and/or therapeutic irradiation. N/V/D bone marrow depression alopecia |
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Methotrexate (MTX) S.E.
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BONE MARROW SUPPRESSION
ULCERATIVE STOMATITIS N/V/D |
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5 Fluorouracil (5-FU) N.I.
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Leucovorin used with 5-FU to neutralize toxic effects and enhance therapeutic effects
Monitor labs for signs of bone marrow suppression Monitor for oral and GI ulceration |
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Methotrexate (MTX) N.I.
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Leucovorin is used to neutralize the toxic effects on the hematological system
USE sunscreen Avoid pregnancy |
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Leucovoran Calcium (Folinic Acid) S.E.
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Allergic reactions
S/S OF HYPERCALCEMIA -LETHARGY -HEADACHE -WEAKNESS -MUSCLE FLACCIDITY -HEART BLOCK -N/V |
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Leucovoran Calcium (Nursing Implications)
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used to treat delayed excretion of MTX or O.D. of MTX. or as rescue after high dose of MTX therapy.
Given with 5-FU to enhance therapeutic effects and neutralize toxicities. |
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Name 1 Plant Alkaloid
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Etoposide (VePesid) (VP-16)
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Etoposide (VePesid) (VP-16) Cell Cycle Affected
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G2 Phase
VP-G2 |
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Etoposide (VePesid) (VP-16)
S.E. |
Peripheral Neuropathy ***
Irritation at injection site Alopecia N/V Constipation Ulcerative Stomatitis |
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Etoposide N.I.
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Anaphylaxis
Monitor s/s of neurotoxicity Avoid extravasation (is a vesicant) Stool softeners Bone marrow suppression |
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Doxorubicin (Ruby-Big red)
Antibiotic Cell Cycle Specific? |
No
Non-Cell-Cycle Specific |
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Doxorubicin (Ruby-Big red)
Antibiotic S.E. |
Cardiac Toxicity
Irritation at injection site Bone Marrow Depression Nausea/Vomiting Alopecia |
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Doxorubicin (Ruby-Big red)
Antibiotic N.I. |
Monitor for signs of cardiotoxicity
Monitor labs May produce red urine for 1-2 days, but it is Not Hematuria Is a vesicant (Apply ice packs and elevate IV site) |
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Bleomycin (Blenoxane)
Antibiotic Cell Cycle Specific? |
yes
Cell-Cycle specific to G-2 (second growth phase) |
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Bleomycin (Blenoxane)
Antibiotic S.E. |
PULMONARY TOXICITY
pneumonitis Pulmonary fibrosis N/V Rashes Fever |
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Bleomycin (Blenoxane)
Antibiotic N.I. |
Monitor Pulmonary Status closely
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Paclitaxel (Taxol)
Cell Cycle Specific? |
Yes
Cell Cycle specific for M (mitosis phases) |
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Paclitaxel (Taxol) S.E.
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BONE MARROW TOXICITY
Allergic reactions Peripheral Neuropathy Respiratory reactions |
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Paclitaxel (Taxol) N.I.
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Severe Neutropenia (Nadir level on day 11,
Severe thrombocytopenia (day 8-9), severe anemia |
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Gemcitabine Hydrochloride (Gemzar)
Cell Cycle Specific |
YES
Cell Cycle Specific for S-Phase and G1 Phase |
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Gemcitabine Hydrochloride (Gemzar) S.E.
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PULMONARY AND HEPATIC TOXICITIES
Bone marrow suppression N/V Alopecia Bone pain |
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Gemcitabine Hydrochloride (Gemzar) N.I.
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Monitor CBC, liver function
Monitor pulmonary status Treat Nausea Treat bone pain |
