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25 Cards in this Set
- Front
- Back
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Ritalin
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Methylphenidate
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Methylin
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Methylphenidate
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Metadate
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Methylphenidate
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Concerta
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Methylphenidate
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Daytrana
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Methylphenidate Patch
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Focalin
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Dexmethylphenidate, can be sprinkled
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Methylphenidate/Dexmethylphenidate MOA
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DA uptake inhibitor
NE uptake inhibitor to a lesser extent |
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Methylphenidate/Dexmethylphenidate PK
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Varies, PO, dex is most active isomer of methylphenidate
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Methylphenidate/Dexmethylphenidate AEs
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Anorexia, insomnia, nervousness, GI distress, irritability, inc crying, tachycardia, inc BP, motor/vocal tics
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Methylphenidate/Dexmethylphenidate Contraindications
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Anxiety, motor tics, MAOIs, cardiac abnormalities, Hx of drug abuse, psychosis Hx, seizure disorder, EEG abnormalities, glaucoma
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Amphetamines MOA
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Enhances release and blocks reuptake of DA and NE
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Dextroamphetamine
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Dexedrine, amphetamine
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Lisdexamphetamine
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Vyvanse, less potential for abuse
1x/day |
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Mixed amphetamine salts
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Adderall, PO
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Atomoxetine General
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Only FDA approved nonstimulant for ADHD
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Atomoxetine MOA
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NE reuptake inhibitor
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Atomoxetine AEs
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Nausea, anorexia, inc pulse/BP, constipation, hepatotoxicity
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Bupropion MOA
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Wellbutrin, DA/NE reuptake inhibitor
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Bupropion Contraindications
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Bulimia, anorexia, seizures, EtOH, sedative abuse Hx, head trauma
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Clonidine/Guanfacine MOA
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Central alpha-2 adrenergic agonists
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Clonidine/Guanfacine AEs
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Sedation, Orthostatic HypoTN, dry mouth
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Modafinil General
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Approved for narcolepsy, lower abuse potential
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Modafinil MOA
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Unclear
Modulates DA, glut/GABA, NE, hypocretin/orexin system |
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Pathophysiology of ADHD
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Reduced brain volume, DA, NE dysregulation in prefrontal cortex, basal ganglia
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Dx criteria for ADHD
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1) Sx present before 7yo in @ least 2 settings
2) Cx significant impairment in social, academic, occupational fxning |
