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8 Cards in this Set
- Front
- Back
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GABA general
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Major inhibitory NT, larger []s than monoamine NTs
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GABA pathways
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1)Long axon tracts connecting regions of basal ganglia, pathway to substantia nigra
2)Interneurons w/in cortex w/in various limbic areas including hippo amyg septum, w/in BG and cerebellum, w/in Raphe Nuclei and w/in medulla and SC |
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GABA shunt
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Closed loop for synthesis of GABA
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Precursor for GABA
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Glucose
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Glutamate to GABA enzyme
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Glutamic acid decarboxylase (GAD)
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Steps in GABA shunt
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1-alpha ketoglutarate formed from glucose metabolism in Krebs cycle converted by alpha-oxoglutarate transaminase into glutamic acid
2-decarboxylated by GAD to GABA 3-Gaba metabolized by GABA-T to succinic semialdehyde 4-SS oxidized by SSADH to succinic acid 5-Re-enters Krebs cycle |
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Termination of axn of GABA
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1-reuptake in presynaptic nn terminal
2-uptake into proximal glial cells |
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Glutamine Loop
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Glial cells take up used GABA and convert to glutamine, a precursor for GABA, Glial cells lack GAD
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