Now

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Question

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Answer

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intricate meshwork of interacting extracellular macromolecules that serve as a universal biological glue.

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Extracellular matrix

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the ECM can exist as highly specialized structures such as

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cartilage, bone, tendons, teeth and the basal lamina

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what are the two components of the ECM

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"1. fibers

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What makes up the fiber part of the ECM

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"1. structural=collagen and elastin

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Describe how GAG's assist in resisting compression and help make a semi-fluid gel in the ECM.

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All but one of the GAG's are sulfated and these have negative charges. These negative charges attract cations such as sodium, high sodium concentration attracts extracellular fluid meaning it is highly hydrated.

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What is the only nonsulfated GAG?

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hyaluronic acid

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What are the five GAG's

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hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan sulfate, and heparan sulfate.

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Type of GAG?"

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hyaluronic acid

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Type of GAG?"

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chondroitin sulfate

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Type of GAG?"

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dermatan sulfate

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Type of GAG?"

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keratan sulfate

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Type of GAG?"

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heparan sulfate

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When sulfated GAG's form covalent bonds with a protein core, they form a family of macromolecules known as the

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proteoglycans

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What are the functions of proteoglycans?

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"1. resist compression

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Expression:"

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Keraton sulfate and chondroitin sulfate; cartilage

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Name the glycoprotein; limited to basal lamina, binds heparan sulfate, type IV collagen, and entactin, and the cell membrane.

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Laminin

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Mats of specialized ECM that underlie all epithelial cell sheets and tubes.

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Basal lamina

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the basal lamina around fat cells, muscle cells, and schwann cells is referred to as

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the external lamina

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What glycoproteins are associated with the basal lamina?

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laminin and entactin

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What is present mainly on the pm side of the lamina densa where it helps bind epithelial cells to the lamina?

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Laminin

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The principal plasma membrane receptors on cells for binding the cytoskeleton to the ECM proteins, including collagen, fibronectin, and laminin are the ?

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integrins

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intricate

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meshwork

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the

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ECM

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what

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are

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2.

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ground

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What

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2.

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adhesive=fibronectin

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Describe

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how

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What

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is

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What

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are

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"Tissue

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Distribution:

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Function:

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resists

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Type

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of

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"Tissue

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Distribution:

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Function:

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forms

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Type

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of

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"Tissue

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Distribution:

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Function:

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binds

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Type

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of

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"Tissue

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Distribution:

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Function:

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mechanical

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Type

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of

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"Tissue

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Distribution:

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Function:

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structural

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Type

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of

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When

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sulfated

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What

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are

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2.

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retard

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3.

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form

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4.

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possess

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"Proteoglycan:

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Aggrecan

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Expression:" Keraton

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sulfate

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Name

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the

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Mats

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of

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the

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basal

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What

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glycoproteins

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What

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is

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The

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principal