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16 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Describe alpha 1 receptors and what happens when stimulated
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Gq coupled, increase IP3 and DAG
- Causes smooth muscle contractions, contraction in the viscera, pupil dilation |
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Describe beta 1 receptors and what happens when stimulated
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Gs coupled receptor- increases cAMP
- Increases heart rate, contractile force and conduction at the AV node |
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What type of receptors are adrenergic receptors?
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GPCRs
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Describe beta 2 receptors and what happens when stimulated
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Gs coupled receptor
- smooth muscle relaxation, vasodilation in smooth muscle (dominant over alpha 1), bronchodilation |
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Describe alpha 2 receptors and what happens when stimulated
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presynaptic and prevents NA release
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What happens when adrenaline stimulates sympathetic NS?
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peripheral resistance decreases, HR increases
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What happens when noradrenaline stimulates sympathetic NS?
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peripheral resistance increases, HR decreases (baroreceptor reflex!)
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What happens in analphylactic shock?
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Severe allergic response - histamine released causing system vasodilation. So BP decrease
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What is used to treat anaphylactic shock and how does it help?
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Adrenaline administered intramuscularly, causes vasoconstriction (skin and viscera) and bronchodilation, also increases HR which will increase BP
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What is the feedback inhibition involving alpha 2 receptors?
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When activated (presynaptically) it reduces cAMP levels which blocks Ca channels, thus inhibitting NA release. Thus BP decreases
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What do MAO inhibitors do?
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less NA degradation, could lead to hypertension
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Give examples of NATs
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Amphetamine, cocaine
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Side effect: hypertension
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Name a alpha 2 agonist
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Clonidine
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Treats hypertension
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Name an a1 agonist
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Phenylephrine
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Treats nasal decongestion
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Name an a1 antagonist
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Prazosin
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Antihypertensive
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Name a B blocker
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Propranolol
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