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14 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Propranolol (MOA & PK)
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MOA - Nonspecific beta receptor blocker, slow heart rate and reduce contractile force, inhibit rennin release from kidney, reduce aqueous humor secretion, bronchoconstriction, inhibit hepatic glycogenolysis, anesthetic properties
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PK PO; extensive first pass metabolism; variable bioavailability; half life 3-6 hours
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Propranolol (CU & T)
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CU - Hypertension; glaucoma; ischemic heart disease; post-MI prophylaxis; stage fright, tremor; migraines; portal hypertension
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence
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Penbutolol (MOA & PK)
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MOA - Partial agonist, similar effects to propranolol, except incomplete blockade of lungs and heart function and no anesthetic action
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PK - PO; high lipid solubility (CNS effects); good bioavailability; half-life 5 hours
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Penbutolol (CU & T)
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CU - Used for hypertension and angina when less bradycardia or bronchodilation is important
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less bradycardia and bronchodilation and perhaps more CNS effects than propranolol
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Pindolol (MOA & PK)
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MOA - Partial agonist, similar effects to propranolol, except incomplete blockade of lungs and heart function
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PK - PO; moderate lipid solubility; good bioavailability; half-life 5 hours
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Pindolol (CU & T)
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CU - Used for hypertension and angina when less bradycardia or bronchodilation is important
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less bradycardia and bronchodilation and perhaps more CNS effects than propranolol
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Carteolol (MOA & PK)
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MOA - Partial agonist, similar effects to propranolol, except incomplete blockade of lungs and heart function and no anesthetic action
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PK - PO/ophthalmic; low lipid solubility; good bioavailability; half-life 5 hours
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Carteolol (CU & T)
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CU - Glaucoma
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less CNS effects than penbutolol
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Nadolol (MOA & PK)
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MOA - Nonspecific beta receptor blocker, slow heart rate and reduce contractile force, inhibit rennin release from kidney, reduce aqueous humor secretion, bronchoconstriction, inhibit hepatic glycogenolysis
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PK - PO; low lipid solubility; good bioavailability; long duration; half-life 14-24 hours
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Nadolol (CU & T)
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CU - Portal hypertension
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less CNS effects than penbutolol
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Sotalol (MOA & PK)
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MOA - Nonspecific beta receptor blocker, slow heart rate and reduce contractile force, inhibit rennin release from kidney, reduce aqueous humor secretion, bronchoconstriction, inhibit hepatic glycogenolysis
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PK - PO; low lipid solubility; good bioavailability; long duration; half-life 12 hours
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Sotalol (CU & T)
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CU - Supraventricular arrhythmias
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence
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Timolol (MOA & PK)
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MOA - Nonspecific beta receptor blocker, slow heart rate and reduce contractile force, inhibit rennin release from kidney, reduce aqueous humor secretion, bronchoconstriction, inhibit hepatic glycogenolysis
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PK - PO/ophthalmic; moderate lipid solubility; good bioavailability; half-life 5 hours
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Timolol (CU & T)
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CU -Topical glaucoma treatment
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence
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