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24 Cards in this Set
- Front
- Back
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TdT positive, lack of gene rearrangement
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"Precursor"
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TdT
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terminal deoxynucleotidyl transferase
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Old man with diffuse proliferation of mature small lymphocytes in lymph nodes, marrow/spleen over the last 6 years. CD19/20 positive. What else is he positive for?
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CD5 & CD23. Small lymphocityc lymphoma or chronic lymphocytic leukemia
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lots of well differentiated lymphicytes and smudge cells. Not many symptoms, old man that's had this for 6 years. At what stage will he get anemia/thrombocytopenia?
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Stage IV: 20 month survival at this point. This is ones tumors start replacing the bone marrow
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What will the old man with CD5/CD23 lymphoma die of eventually?
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infection because he has hypogammaglobulinemia
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Very little lymphadenopathy but massive splenomegaly and inflitration of the marrow. What else will you see?
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Positive for acid phosphatse even in the presence of tartrate (TRAP). This is hairy cell leukemia
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CD19/20/5 postive but CD23 negative
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Mantle cell lymphoma
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t(11;14) activates bcl-1 which leads to excessive...
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cyclin D1
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CD19/20 CD10 (CALLA)
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Follicular lymphoma
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t(14;18) of bcl2
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Follicular lymphoma
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75% already involve marrow at diagnosis-widely disseminated
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follicular lymphoma
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when becomes LARGE & diffuse =
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progressive/agrressive!
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lymphoma outside of the lymph node, arises in MALT
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marginal zone lymphoma
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stay at MALT location, and only disseminated (go to lymph nodes) late in disease course
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marginal zone lymphoma
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H. pylor => MALToma
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marginal zone lymphoma
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CD19/20 & CD10 (CALLA) in kids with starry sky
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Burkitt lymphoma
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cmyc gene from chromosome 8 to 14
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Burkitt Lymphoma
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EBV, jaw bone or ovaries
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Burkitt lymphoma
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involves mediastinum, CNS, kin. TDTpositive, CD3
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lymphoblastic lymphoma/leukemia (MAJORITY OF KIDS)
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nonspecific skin lesions which lead to skin tumors (Patrier abscesses)
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Mycosis fungoides (malignant CD4)
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Patrier abscesses which spread to viscera
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Sezary syndomre: generalized red skin and malignant cells in peripheral blood
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HTLV1 in Japan/Caribbean. high grade, poor prognosis :(
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Adult T cell (CD4) leukemia/lymphoma
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AIDS associated (high grade Bcell type
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Burkitts and DLBCL
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transplant patient that is immunosupressed gets lymphoma. EBV associated
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if regresses with decreased immunosuppresion then NOT LYMPHOMA
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