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19 Cards in this Set
- Front
- Back
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What are isomers?
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Isomers are molecules that have the same molecular formula, but have a different arrangement of the atoms in space
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What are the two classes of ismoers?
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1- structural isomers
2- stereoisomers |
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What are structural isomers?
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Where the atoms making up the various isomers are joined up in a different order, this is known as structural isomerism. Structural isomerism is not a form of stereoisomerism, and is dealt with on a separate page.
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What are stereoisomers?
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In stereoisomerism, the atoms making up the isomers are joined up in the same order, but still manage to have a different spatial arrangement
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Geometric isomers?
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Cis/ trans stereoisomers
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Define isomers again.
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isomers are chemical compounds that have same chemical forumla, but different structural formula
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What are the two classes of stereisomers.
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1-optical stereoismers
2-geometric stereoismoers |
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What are gemometric isomers?
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isomers that have the same chemical structure, with atoms arranged by the same covalent bonds, HOWEVER SOME GROUPS HAVE DIFFERENT SPATIAL ARRANGEMENT
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What type of molecules can be geometric isomers?
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when a molecule have two dissimilar side groups, attached to two different carbon atoms, linked by either a double bond or a ring structure
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What are the two type of the geometric isomers?
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Cis and trans
if the two side groups are on the same side of the covalent bond -->cis if at opposite sides -->trans |
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what are optical isomers?
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molecules that are mirror images of each other, and cannot be super-imposed
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Which NMBD's are in the benzylisoquinolinium group?
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-atracurium
-mivacurium |
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Which are steroids?
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--> all those ending with 'curonium':
1-pancuronium 2-rocuronium 3-vecuronium |
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List the possible mechanisms of a phase II block when large dose of Sux is used.
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1.Receptor desensitization
2.Ion channel blockade 3.Entrance of sux into the cytoplasm of the muscle fiber 4.?pre-synaptic effect |
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Define ED-95 (in respect to NMBD's)
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it is the dose of NMBD required to produce 95% suppression of the single-twitch response measured at adductor pollicus.
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What is the intubating dose of a NMBD in respect to ED-95?
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2.5 x ED-95
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Which class of NMBD's does vecuronium belong to?
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(ronium) -->amino-steroids
Intermediate-acting |
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How many ACh molecules are needed to activate one nAChR?
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two ACh molecules
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What are the different pathways for elimination of NMBD's?
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1-excretion as unchanged drug in urine,
2- metabolism in the liver, 3-enzymatic hydrolysis, 4-and chemical breakdown |
