Nku Nrs255 - E2 -Anti-(Fungal, Viral, Inflammatory, Neoplastic) Drugs

Front 1

Drug used to treat influenza A & B; can shorten the duration of illness.

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oseltamivir (Tamiflu)

Front 2

NSAID used to treat dysmenorrhea, pain, and imflammation.

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naproxen (Naprosyn)

Front 3

Main use is to suppress HSV-1 & HSV-2 replication.

Back 3

acyclovir (Zovirax)

Front 4

Anti-pyretic & anti-inflammatory with limited intake of 4g/day

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acetaminophen (Tylenol)

Front 5

Nucleoside reverse transcriptase inhibitor (RTI) that stops viral replication of HIV; used to prevent maternal to fetal HIV transmission.

Back 5

zidovudine (AZT)

Front 6

Drug of choice for treatment of systemic fungal infections with adverse effects including fever, chills, hypotension, nausea, vomiting, and headache.

Back 6

amphotericin B (Amphocin)

Front 7

Anti-protozal and antibacterial medication used in treatment of dysentery, venereal disease, peritonitis, bone & skin infections; turns urine dark reddish brown.

Back 7

metronidazole (Flagyl)

Front 8

Can cause tinnitus & increased potential to bleed as well as GI distress; normal dose is 81 - 325mg

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aspirin / acetylsalicylic acid

Front 9

Salicylate used to treat pain, fever & inflammation, in adults; should be taken with food to decrease GI upset; can cause liver, kidney, and ear dysfunction.

Back 9

salsalate (Argesic)

Front 10

Non-nucleoside reverse transcriptase inhibitor (RTI) used in treatment of HIV; used to treat patients who have immunological deterioration with other drugs; can cause liver dysfunction.

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nevirapine (Viramune)

Front 11

NSAID; COX 2 inhibitor.

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celecoxib (Celebrex)

Front 12

Systemic corticosteroid used to treat inflammatory disorders.

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dexamethosone (Decadron)

Front 13

Systemic corticosteroid with some mineralocorticoid activity.

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prednisone (Deltasone)

Front 14

Inhaled corticosteroid used to treat the respiratory tract.

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beclomethasone (Beclovent)

Front 15

Disease modifying anti-rheumatic drug (DMARD) that can cause bone marrow suppression.

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etanercept (Enbrel)

Front 16

Used in the treatment of herpes infections; nursing implications include: increasing fluid intake while taking drug and avoiding sexual contact when lesions are visible.

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valacyclovir (Valtrex)

Front 17

Anti-fungal agent used to treat vaginal candidiasis that can cause increased AST and ALT levels.

Back 17

fluconazole (Diflucan)

Front 18

Fusion inhibitor used in the treatment of HIV possibly in combination with retro-virals; inhibits the fusion of the virus with the cell membrane; can cause injection site reactions & pneumonia

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enfuvirtide (Fuzeon)

Front 19

Prophylaxis and treatment of influenza A in adults; prophylaxis of influenza A in children; inhibits viral replication.

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rimantadine (Flumadine)

Front 20

Used to treat cytomegalovirus (CMV); can be toxic to the bone marrow & kidney.

Back 20

ganciclovir (Cytovene)

Front 21

Viruses that respond to anti-viral therapy.

Back 21

influenza A, CMV, Mono

Front 22

Adverse effects of corticosteroids.

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Assoicated with hyperglycemia, immunosuppression, insomnia, fatigue, osteoporosis, fluid retention, upset stomach.

Front 23

Considerations for administration of corticosteroids.

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Limit topical use in children, do not use near open wounds, take in morning.

Front 24

Physiological effects of glucocorticoid release from adrenal cortex.

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Increased: heart rate, blood pressure, blood glucose, protein breakdown; mobilize energy storage of fat; euphoria, sleep pattern.

Front 25

Physiological effects of mineralocorticoid release from adrenal cortex.

Back 25

Increased BP; aldosterone - re-absorption of H2O and sodium with excretion of potassium.

Front 26

T/F: Elderly patient who takes an anti-viral agent is more susceptible to adverse effects than the adult patient.

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TRUE

Front 27

T/F: amantadine (Symmetrel) can be used to treat influenza A as well as Parkinson's Disease.

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TRUE

Front 28

T/F: It is acceptable for a pregnant nurse to care for patients with herpes.

Back 28

FALSE

Front 29

T/F: Anti-viral agents used to treat influenza should be taken w/in 48-72 hours of the onset of flu symptoms to increase the potential for effectiveness.

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TRUE

Front 30

T/F: raltegravir (Insentress) is an integrase inhibitor used in the treatment of HIV that can cause rhabdomyolysis (breakdown of muscle).

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TRUE

Front 31

T/F: Liver function tests (LFTs) must be monitored with a patient taking metronidazole (Flagyl).

Back 31

TRUE

Front 32

T/F: NSAIDs can cause bleeding tendencies & kidney dysfunction, as well as gastrointestinal distress.

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TRUE

Front 33

T/F: anakinra (Kineret) is a DMARD (disease modifying anti-rheumatic drug) that is injected & can cause local irritation at the injection site.

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TRUE

Front 34

T/F: Abrupt withdraw of exogenous corticosteroids can lead to adrenal insufficiency.

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TRUE

Front 35

T/F: Administration of inhaled corticosteroids can lead to oral fungal infections.

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TRUE

Front 36

Most common form of leukemia in adults; typically has poor prognosis.

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Acute myelogenous leukemia (AML)

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Disease where malignant B cells invade the lymphoid tissue.

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Hodgkin's Disease

Front 38

Alkylating agent used in the treatment of chronic lymphocytic leukemia (CLL), malignant lymphomas, and Hodgkin's disease.

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chlorambucil (Leukeran) *slow growing tumors*

Front 39

Mitotic inhibitor used in the treatment of acute leukemia, Hodgkin's Disease, and non-hodgkin's disease; very constipating, patient should be encouraged to drink lots of water.

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vincristine (Oncovin)

Front 40

Hormone modulator used in the treatment of breast cancer.

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tamoxifen (Tamofen)

Front 41

Curable leukemia in children; worse prognosis for adults.

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Acute Lymphocytic Leukemia (ALL)

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Colony stimulating factor that promotes the production of WBCs

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filgrastim (Neupogen)

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Leukemia seen typically seen in older adults; if diagnosed early can have good prognosis.

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Chronic Lymphocytic Leukemia (CLL)

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Monoclonal antibody that suppresses the Philadelphia chromosome.

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imatinib (Gleevec) *very specific to cancer cells*

Front 45

Hematological disorder that increases the risk of infection.

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Neutropenia

Front 46

Disease associated with herpes and Epstein Barr virus; incidence is increased in immunosuppressed patients.

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Non-Hodgkin's Disease *T & B cells*

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Anti-neoplastic antibiotic used in he treatment of leukemias and breast cancer; can cause urine to be red.

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doxorubicin (Adriamycin)

Front 48

Anti-metabolite that inhibits DNA synthesis and cell replication; effective against rapidly growing cancers; can cause CNS and GI disturbances.

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methotrexate (Rheumatrex)

Front 49

Abnormal immunoglobulin is formed; proliferation of osteoclasts causes breakdown of bone; patient has hypercalcemia.

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Multiple Myeloma

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Specific marker is the Philadelphia chromosome; typically occurs in mid-life.

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Chronic Myelogenous Leukemia (CML)