Nitrogylcerin

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Other names for Nitrogylcerin

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Nitrosat; Nitro-Bid; Tridil

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Class:

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Nitrate; Antianginal; Vasodialtor

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Action: Primary

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Primary effect: vasodilation of coronary and cerebral arteries, which causes the following which relieves vasopasms: 1)increases oxygen availability to the heart and the brain
2)decreased workload and myocardial oxygen demand

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Action: Secondary

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Secondary effect is vasodialation of vascular smooth muscle which causes: 1) increase in coronary blood flow 2) a reduction in preload

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Action: continued

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Acts as a smooth msucle relaxant;
Onset of action is within 1-2 min
Antiangianl effect preceds hemodynamical effect

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Use:

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1)Ischemic chest pain& anginal equivilents 2) Pulmonary edema

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Side Effects:

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Headache,Syncope, Hypotension, Heart Rate Changes, Bitter Taste, Burning under tongue

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CONTRAindiactions

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Absolute: Cerebral Hemorrhage; Chest trauma; head injusry; Hypotension; Hypersensitivity; meds for E.D. ex:Viagra w/i 24hrs

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Drug interactions #1-2

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1) use with alcohol, B blockers, phenothiazines, and other vasodilators may potentiate hypotension 2) Nitro rapidly deteriorates if exposed to the air, light, or temp, changes

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Drug interactions #3

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Use with calcium channel blockers can result in symptomatic orthostatic hypotension

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Preparations:

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0.4mgtablet-Nitrostat
0.4mg/metered dose aerosol spray-Nitrolingual Spray Ointment-Nitro-Bid

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Adult Dose:

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SL Tablet or spray: 0.4mg. May be rptd. q 5 min, as long as BP is above 90mm/hg
Ointment: 1 to 2in.(15 to 30mg) on the chest wall

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Pediatric Dose:

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Not recommended for Out-of-hospital use

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Route:

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SL; Transdermal

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Precautions

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1) Use with caution with PTs taking Viagra or E.D meds withing 24 hrs/ contact med. control
2) If using spray, DON'T shake before administration