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5 Cards in this Set
- Front
- Back
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What is the maturation sequence of granulocytes?
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myleoblast
promyelocyte myelocyte metamyelocyte band segmented |
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Neutropenia defined:
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Absolute neutrophil count (ANC): less than 1500/ul
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Severe Congenital Neutropenia?
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Defect in neutrophil elastase (ELA2) mutations, so improper tissue homing
15% develop MDS/AML Tx: G-CSF and transplant |
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Cyclic neutropenia?
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congenital neutropenia
21 day cycles with variable severity, recurrent fever, mouth sores, URIs NO HIGHER RISK FOR MDS OR AML (unlike SCN or SBDS) |
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Schwachman-Diamond syndrome (SBDS)?
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congenital neutropenia
AR utation in SBDS gene that causes defects, pancreatic insufficiency, short stature Tx: G-CSF |
