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11 Cards in this Set
- Front
- Back
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Acetocholine
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EPSP
•Only transmitter at the neuromuscular junction •All pre ganglionic transmission in both the sympathetic and parasympathetic •Most post ganglionic in para •Formed by choline acetyltransferase • Degraded by acetyl cholinesterase |
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Dopamine, Norepinephrine, and epinephrine
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EPSP
•All from tyrosine •Metabolized by Mono amine oxidase and catechol o methyltransferase •Neurons make norepinephrine •Adrenal medulla make Epi (Tyrosine--> Dopamine--> norepinephrine--> epinephrine) |
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Serotonin
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EPSP
•Made from tryptophan •Degraded by MAO to 5 hydroxyindoleactic acid •Turned into melatonin in the pineal gland |
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Glutamate
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EPSP
- CNS excitatory |
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Glycine and GABA
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IPSP
- CNS inhibitor - Opens chloride channels |
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EPSPs
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oDepolarize the post synaptic cell
oOpen sodium and potassium channels oMake more positive oTransmitters •Ach •Dopamine •Glutamate •Serotonin |
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IPSPs
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oHyperpolarize
oMake the membrane more negative oOpens chloride channels oTransmitters • GABA • Glycine |
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Botulinus Toxins
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oBlocks release the Ach pre synaptic terminal
oParalyses skeletal muscle oDeath from respiratory failure |
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Curare
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oCompletes with Ach
oBlocks Ach at post synapse nicotinic receptor oLarge doses paralysis, reparatory failure and death |
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Atropine
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Blocks muscarinic in saliva and bowels
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Acetylcholine esterase inhibitors
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oBlock degradation of Ach in neuromuscular junction
oIncrease Ach level oBest initial therapy for myasthenia gravis oDoes not delay progression of disease oEdrophonium is a diagnostic test. |
