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19 Cards in this Set
- Front
- Back
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The enzyme that synthesizes Ach.
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Choline acetyltransferase
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Acetyl CoA come from metabolism of this in the mitochondria
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Pyruvate
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Choline Esterases turn Ach into these two molecules
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Choline and Acetate
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What is the effect of Hemicholinium?
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It depletes Ach levels by making Ch scarce
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What is the effect of Bungarotoxin?
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Releases vasicles of Ach, depleting numbers for future release.
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3 Nicotinic agonists
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1. Ach
2. Nicotine 3. Carbachol |
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3 Nicotinic antagonists
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1. Curare
2. Succinylcholine 3. Rabies Virus |
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4 Muscarinic agonists
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1. Ach
2. Muscarine 3. Pilocarpine 4. Oxotremorine |
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2 Muscarinic antagonists
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1. Atropine
2. Scopolamine |
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Muscarinic receptors use G-proteins as coupling mechanism to accomplish 4 different tasks.
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1. Inhibit adenylate cyclase
2. Stimulate Guanylate Cyclase 3. Stimulate phospholipase C 4. Alter Ca and K Ion channels |
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3 catecholamines and what they share in common
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--Dopamine, epinephrine, norepinephrine
--L-tyrosine precursor |
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Catechol-o-methyl-transferase acts on what group and has what inhibitor?
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1. Catechol groups
2. Troplone |
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1. Monoamine Oxidase's primary function.
2. MAO inhibitor will increase what? 3. MAO Inhibitors primary pharmacological uses (2). |
1. Storage of neurotransmitters thru reuptake.
2. Levels of Nore, Epi, dopamine in nerve terminals 3. Antidepressants and blood pressure regulator |
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What is location and function of the locus coeruleus?
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It is located lateral to the 4th ventricle and it contains the cell bodies of noradrenergic neurons. (Principle site of synthesis)
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What is the location and function of the substantia nigra?
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Located in midbrain, contains cell bodies that produce dopamine.
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D1 family of dopamine receptors have what effect on cAMP levels inside the cell?
Decrease in activity is caused by what chemical? |
Increase; Bromocryptine
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D2 family of dopamine receptors have what effect on cAMP levels inside the cell?
Decrease in activity is caused by what chemical? |
Decrease; Butryophenone
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2 Adrenergic receptor agonists
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1. ephedrine (alpha)
2. isoprotenerol (beta) |
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2 Adrenergic receptor antagonists
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1. phenoxybenzamine (alpha)
2. propanolol (beta) |
