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11 Cards in this Set
- Front
- Back
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name the 9 steps of exocytosis.
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1.docking 2.priming 3.fusion 4. endocytosis 5. translocation 6.endosome fusion 7.budding 8.NT uptake 9.translocation
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what is the function of synaptotagamin (St)?
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it is the calcium sensor needed for secretion
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how does docking work?
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secretory vesicles proteins have a high affinity for membrane bound proteins.
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what is hemifusion and how is it achieved?
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the fusion of lipidbilayers by consumption of ATP.
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what happens after endoocytosis?
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the vesiclemembrane is reuptaken after it is coated with clathrin, which binds to synaptotagamin through adapter protein 2 (AP2)
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what is a second way of the endocytose circle?
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the vesicle isn't translocated, but instead stays near the membrane and is reloaded with NT. called the 'local cycle'
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how many vesicles are involved in local cycles?
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17 to 20
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how many vesicles are involved in the endosomal cycle?
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about 200
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how can the local cycle and endosomal cycle be further defined?
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the local cycle contains mostly electron lucent vesicles, involved in ionotropic actions, the endosomal cycle contains dense core vesicles, involved in metabotropic, more permanent pathways.
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how is release of vesciles regulated in the two cycles?
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dense core vesicles are released on high frequenty discharge, the local cycle releases on low frequenty discharge.
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how can the difference in release patterns between the two cycles be explained?
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dense core vesciles need a high Ca2+ concentration released from intracellular storage when enough VOCC's are activated by SMNT
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