Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
39 Cards in this Set
- Front
- Back
|
What is the enzyme responsible for the synthesis of acetylcholine?
|
Choline acetyltransferase
|
|
|
What two substrates are needed to synthesize acetylcholine?
|
Choline and acetyl CoA
|
|
|
What enzyme is responsible for the degradation of acetylcholine?
|
acetylcholine esterase
|
|
|
What are the two cholinergic receptors?
|
The Nicotinic receptor and the Muscarinic receptor.
|
|
|
The binding of acetylcholine to the nicotinic receptor causes postsynaptic membrane ___________.
|
Depolarization
|
|
|
The binding of acetylcholine to the muscarinic receptor induces activation of?
|
phospholipase C (PLC)
|
|
|
Dopamine is produced from which amino acid?
|
Tyrosine
|
|
|
The rate limiting step in the synthesis of dopamine is?
|
Tyrosine hydoxylase
|
|
|
The two enzymes responsible for the breakdown of dopamine are:
|
MAO-monoamine oxidase & COMT- Catechol-O-methyltransferase
|
|
|
Dopamine has been linked to which disease?
|
Parkinson's Disease
|
|
|
Dopamine binds to a class of receptors referred to as D1-D5 receptors. These receptors are ionotrophic or metabotrophic?
|
Metabotrophic receptors. They either result in the activation of a G-stimulatory protein (Gs) or a G-inhibitory protein (Gi).
|
|
|
Norepinephrine is synthesized from dopamine by the enzyme:
|
Dopamine beta-hydroxylase
|
|
|
Synthesis of Norepinephrine occurs in what specific location of the neuron?
|
In the vesicle
|
|
|
The two types of norepinephrine receptors are:
|
alpha & beta adrenergic receptors.
|
|
|
Norepinephrine degradation involves which two enzymes?
|
MAO & COMT
|
|
|
What amino acid is required for serotonin synthesis
|
Tryptophan
|
|
|
Glutamate is produced from the amino acid:
|
glutamine
|
|
|
Glutamine is converted to glutamate by:
|
Glutaminase
|
|
|
The breakdown or recycling of Glutamate involves which cells?
|
The Glial Cells
|
|
|
Glutamate is reabsorbed in the pre-synpatic neuron as:
|
Glutamine
|
|
|
GABA is produced from which amino acid?
|
Glutamine
|
|
|
GABA breakdown occurs in which cell?
|
The Glial Cells
|
|
|
GABA is reabsorbed as:
|
Glutamine
|
|
|
Asparate is a excitatory or a inhibitory neurotransmitter?
|
Excitatory Neurotransmitter
|
|
|
Glycine is a excitatory or a inhibitory neurotransmitter?
|
Inhibitory neurotransmitter
|
|
|
GABA, Glutamate, Asparate, & Glycine are synthesized from:
|
Glucose
|
|
|
Where are neuropeptides synthesized at?
|
In the cell body and packaged into vesicles where they are transported to the pre-synpatic terminal.
|
|
|
Nitric Oxide is synthesized from:
|
the conversion of L-arginine to citrulline.
|
|
|
What enzyme is involved in the synthesis of nitric oxide?
|
Nitric oxide synthase
|
|
|
Nitric oxide is referred to as:
|
a retrograde neurotransmitter.
|
|
|
The drug cocaine is responsible for _________ dopamine reutake.
|
blocking
|
|
|
A drug that inhibits monoamine oxidase would (increase or decrease) the concentration of dopamine in the synaptic cleft.
|
increase
|
|
|
A drug that inhibits acetylcholineesterase would increase or decrease the activity of postsynaptic cholingeric neurons.
|
increase
|
|
|
The ionotropic receptor for serotonin is:
|
5-HT3
|
|
|
Most of the small molecule neurotransmitters origniates from:
|
Glucose
|
|
|
The glial cell is responsible for the reuptake of:
|
Glutmate and GABA
|
|
|
The peptide neurotransmitter enkephalin is responsible for mediating:
|
Pain
|
|
|
Nitric oxide is referred to as a retrograde neurotransmitter because:
|
the signal originates in the postsynapatic neuron.
|
|
|
List the three classes of neurotransmitters?
|
Small molecule NT
Peptide NT Hydrophobic or gaseous NT |
