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44 Cards in this Set

  • Front
  • Back
What is the origin of the anterior choroidal artery and what does it supply?
MCA; supplies lateral ventricles, optic tract, basal ganglia (strokes cause Parkinson's on contralateral)
vincristine?
chemotherapeutic that interfers w/ MT involved in cell division, also causes tingling
tau?
associated with fibrillary tangles
What molecules (3) do astrocytic end feet produce to glue membranes together?
Occludin, Claudin, Cadherin
What is VEGF released by?
among other things, astrocytes to stim new vessel growth
What does angiopoietin I do?
induces tight junction formation
MCAM?
during myelin wrapping MCAM family of cell adhesion molecules initiate contact b/t processes and axons
phospholipid proteins with respect to myelin?
anchor inside membrane and glue adjacent membranes together
4-aminopyridine?
blocks K channels and lengthens AP by bridging single demyelinated areas
what is the gene shiver involved in?
point mutation in MBP almost no myelin (MS implications)
What are the antagonist to BMP?
Noggin, Chordin, Follistatin
What two chemicals are involved in the fusion of neural folds?
N-cadherin and N-Cam
The dorsal epidermis establishes what type of gradient?
BMP
The notochord produces what type of gradient?
Shh (high levels at ventral floor)
What four signals are involved in the A/P axis formation?
Wnt, BMP, retinoic acid, FGF
What ECM molecule is involved in migration?
main one: Reelin
What are ApoE and VLDL receptors involved in?
cortical development
What happens if megalin is knocked out?
holoprosencephaly- LDL receptor
tetrodotoxin?
blocks Na channels
What is the cause of Charcot-marie tooth disease?
loss of peripheral axons due to demyelination
penicillin?
in high doses blocks GABA receptors
MAM?
methylasomethanol- causes neuromigratory problems (heterotopias- Kv4.2)
tetraethylammonium?
K channel blocker
RCK loop?
regulatory domain involved in K conductance also has neg. charged aa.
what channel has constitutively bound calmodulin?
SK
neostigmine?
acetylcholinesterase inhibitor
a-bungarotoxin?
irreversibly binds antibody in MG against AchR (nicotinic)
curare?
blocks nicotinic AchR
synaptotagmin?
Ca sensor for fusion of vesicles
What are the Small MW NT (4 groups)?
1.Ach
2.A.A.- Glutamate, GABA, glycine
3.Nucleotides- ATP and adenosine
4.Biogenic amines- catecholamines:Dop, Epi, NE
Indoleamines: 5-HT, His
What are the neuropeptides?
1.Hypothalamic-somatostatin, ADH
2.Opiates- B-endorphins and enkephalins
3. Gut-Brain: Neuropeptide Y and cholecystokinin
4. Nerve growth factor: NGF and BDNF
Both Ionotrophic and Metabotropic?
1. Glutamate
2. Ach
3. GABA
4. 5-HT
Just ionotropic?
Glycine
Just metabotropic?
1. Dop
2. NE
3. all neuropeptides
4. Sensory receptors (vision, olfaction, taste, etc)
strychnine?
glycine antagonist
What is the cause of stiff/ startle baby?
mutated a1 of Glycine
GABA agonist?
benzodiazepines, barbituates, alcohol
GABA antagonist?
Bicuculline
ketamine and PCP?
NMDA antagonist
amphetamines with respect to both Dop and NE?
run dopamine transporters in reverse and cause NE release
Ritalin?
blocks both dopamine and NE transport
MDMA?
ectasy, serotonin
what are endorphins, opium, and morphine agonist of?
Histamine and opiates
caffiene?
antagonist of adenosine receptors