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20 Cards in this Set

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Anti-depressant that can cause increased ocular pressure and orthostatic hypotension?
Citalopram

"When you cit up your BP goes down"
List the SSRI drugs
Fluoxetine, paroxetine, sertraline, citalopram
"-oxetine, + I'm sertain that the city is depressed and needs serotonin"
Toxicity of SSRIs
-GI, sexual dysfuncition, Serotonin syndrome (hyperthermia, muscle rigidity, cardiovascular collapse, flushing, diarrhea, seizures.
Tricyclic antidepressant drugs?
Imipramine, amitriptyline, desipramine, nortriptyline, clomipramine, doxepin, amoxapine

I'M DESPerately AMITing that the DOXin on AM OX did NORT CLOMmer"
Which tricyclic has the least sedating side effect?
Desipramine

'if you're depressed try despipramine before other tricyclics"
Toxicity of tricyclics?
-Convulsions, Coma, Cardiotoxicity, Confusion (in elderly
-Also respiratory distress ("Cough") and ("Catastrophically" high temp)
Tx for absent seizures?
Valproic acid and ethosuximide

Ethyl and Val have absent minds
Succinylchoilne
-m. parlaysis, depolarizing neuromuscular blocking drug
-hypercalciemia and hyperkalemia
-initially causes fasciculations before paralysis

"SUCks to be HYPER-paralyzed and DEPLOyed"
Dantrolene
-tx for malignant hyperthermia caused by inhalation of anesthetics (except N2O) and succinylcholine.
-also used to tx neuroleptic malignant syndrome (toxicity of antipsychotic drugs)
Mechanism of Dantrolene?
prevents release of Ca++ from the sarcoplasmic reticulum of skeletal m
Parkinson's drugs: Agonize dopamine receptors
Bromocriptine, pergolide (ergot alkaloid and partial dopamine agonist), pramipexole, ropinrole (non-ergot)

"At the PARK, PRAM was in AGONy thinking about how she would PERform on the BROwn tight-ROPe"
Parkinson's drugs: increase dopamine
Amantadine (may increase dopamine release)

toxcity= ataxia

At the PARK, A man to dine was ataxically drunk
Parkinson's drugs: Prevent dopamine breakdown
Selegiline (selective MAO type B inhibitor), entacapone, tolcapone (COMT inhibitors, prevent L-dopa degredation, thereby increasing dopamine availability)

al, -CAPONE came to the PARK and was SELEctive about PREVENTing anyone from BREAKING DOWN his operations.
Parkinson's drugs: curb excess, cholinergic excess
Benztropine

There was a BENZ at the PARK
Carbidopa
-a carboxylase inhibitor given with l-dopa in order to increase the bioavailability of L-dopa in the brain and to limit peripheral side effects
-it inhibits the breakdown of levadopa and decreases the side effects (N/V, arrhythmias, N/V, postural hypotension, hot flashes)
What drug may enhance the adverse affects of L-dopa?
Selegiline
Memantine
-used in alzheimer's
-NMDA receptor antagonist; helps prevent excitotoxicity (mediated by Ca++)
-toxicity = dizziness, confusion, hallucinations

"to improve your memory take memantine"
Acteocholinesterase inhibitors used in Alzheimer's?
Donepezil, Galantamine, Rivastigime

Alzheimer pt was DONE RIVALing the GALAxy. He just wanted to sleep

toxicity=N, dizziness, insomia
Huntington's disease drugs
Reserpine + tetrabenzamine: amine depleting

Haloperidol: receptor antagonist
Sumatripan
5-HT agonist. Causes vasoconstriction, inhibition of trigeminal activation and vasoactive peptide release. Half life < 2 hours
-use: Acute migraine, cluster headache attacks
-toxicity: Coronary vasospasm (C/I in pts with CAD or Prinzmetal's angina) mild tingling

"SUMo wrestler TRIps and falls on your HEAD"