Neuro/psych Drugs

Front 1

Anti-depressant that can cause increased ocular pressure and orthostatic hypotension?

Back 1

Citalopram

"When you cit up your BP goes down"

Front 2

List the SSRI drugs

Back 2

Fluoxetine, paroxetine, sertraline, citalopram
"-oxetine, + I'm sertain that the city is depressed and needs serotonin"

Front 3

Toxicity of SSRIs

Back 3

-GI, sexual dysfuncition, Serotonin syndrome (hyperthermia, muscle rigidity, cardiovascular collapse, flushing, diarrhea, seizures.

Front 4

Tricyclic antidepressant drugs?

Back 4

Imipramine, amitriptyline, desipramine, nortriptyline, clomipramine, doxepin, amoxapine

I'M DESPerately AMITing that the DOXin on AM OX did NORT CLOMmer"

Front 5

Which tricyclic has the least sedating side effect?

Back 5

Desipramine

'if you're depressed try despipramine before other tricyclics"

Front 6

Toxicity of tricyclics?

Back 6

-Convulsions, Coma, Cardiotoxicity, Confusion (in elderly
-Also respiratory distress ("Cough") and ("Catastrophically" high temp)

Front 7

Tx for absent seizures?

Back 7

Valproic acid and ethosuximide

Ethyl and Val have absent minds

Front 8

Succinylchoilne

Back 8

-m. parlaysis, depolarizing neuromuscular blocking drug
-hypercalciemia and hyperkalemia
-initially causes fasciculations before paralysis

"SUCks to be HYPER-paralyzed and DEPLOyed"

Front 9

Dantrolene

Back 9

-tx for malignant hyperthermia caused by inhalation of anesthetics (except N2O) and succinylcholine.
-also used to tx neuroleptic malignant syndrome (toxicity of antipsychotic drugs)

Front 10

Mechanism of Dantrolene?

Back 10

prevents release of Ca++ from the sarcoplasmic reticulum of skeletal m

Front 11

Parkinson's drugs: Agonize dopamine receptors

Back 11

Bromocriptine, pergolide (ergot alkaloid and partial dopamine agonist), pramipexole, ropinrole (non-ergot)

"At the PARK, PRAM was in AGONy thinking about how she would PERform on the BROwn tight-ROPe"

Front 12

Parkinson's drugs: increase dopamine

Back 12

Amantadine (may increase dopamine release)

toxcity= ataxia

At the PARK, A man to dine was ataxically drunk

Front 13

Parkinson's drugs: Prevent dopamine breakdown

Back 13

Selegiline (selective MAO type B inhibitor), entacapone, tolcapone (COMT inhibitors, prevent L-dopa degredation, thereby increasing dopamine availability)

al, -CAPONE came to the PARK and was SELEctive about PREVENTing anyone from BREAKING DOWN his operations.

Front 14

Parkinson's drugs: curb excess, cholinergic excess

Back 14

Benztropine

There was a BENZ at the PARK

Front 15

Carbidopa

Back 15

-a carboxylase inhibitor given with l-dopa in order to increase the bioavailability of L-dopa in the brain and to limit peripheral side effects
-it inhibits the breakdown of levadopa and decreases the side effects (N/V, arrhythmias, N/V, postural hypotension, hot flashes)

Front 16

What drug may enhance the adverse affects of L-dopa?

Back 16

Selegiline

Front 17

Memantine

Back 17

-used in alzheimer's
-NMDA receptor antagonist; helps prevent excitotoxicity (mediated by Ca++)
-toxicity = dizziness, confusion, hallucinations

"to improve your memory take memantine"

Front 18

Acteocholinesterase inhibitors used in Alzheimer's?

Back 18

Donepezil, Galantamine, Rivastigime

Alzheimer pt was DONE RIVALing the GALAxy. He just wanted to sleep

toxicity=N, dizziness, insomia

Front 19

Huntington's disease drugs

Back 19

Reserpine + tetrabenzamine: amine depleting

Haloperidol: receptor antagonist

Front 20

Sumatripan

Back 20

5-HT agonist. Causes vasoconstriction, inhibition of trigeminal activation and vasoactive peptide release. Half life < 2 hours
-use: Acute migraine, cluster headache attacks
-toxicity: Coronary vasospasm (C/I in pts with CAD or Prinzmetal's angina) mild tingling

"SUMo wrestler TRIps and falls on your HEAD"