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17 Cards in this Set

  • Front
  • Back

Kleims Principles of Neruo Plasticity

List Risati




L - use it or lose it


I - Use if and improce it


S - Specificity


T - Time maters




R - Repetition


I - Intensity


S - Salience


A - Age


T - Transference


I - Interference

Describe Use it or Lose it

Failure to drive specific function leads to degradation of the function

Describe Use it and Improve it

Training that drive specific function will tend to improve that function

Describe specificity

The nature of the training experience dictates the nature of the plasticity

Describe Repetition

Induction of plastic change requires sufficient repetition

Describe Intensity

Induction of plastic chance requires a high enough level of intensity to precipitate change

Describe Time

Different forms of plasticity occur at difference times during training

Describe Age

Training occurs more readily in young brains

Describe Salience

The training must be important enough to the pt to precipitate change

Describe Transference

Plasticity in response to one training experience can enhance acquisition of similar behaviors

Describe Interference

Plastic response to one experience can interfere with acquisition of other behaviors

What can explain spontaneous recovery

•Naturalhealing with recovery of blood flow and metabolism


•Naturalcompensatory behaviors develop


•Substantialneurophysiological and neuroanatomical reorganization following injury

Describe the recovery of blood flow and metabolism theory

•Diaschisis – an area of the brain, connected byneurons but remote to the area of focal injury, that experiences sudden loss offunction


---Associatedareas of brain undergo reduced metabolism and blood flow following injury


---Asa result of natural healing, reversal or resolution of this altered flow occurswithin first month of injury with concomitant improvement and return offunction

Describe the compensatory movement theory

Outcomes measure function but not quality of movement




Shortly after injury, pts will develop compensatory movements using preserved proximal and axial muscles




A repeated outcome will document improved function, but not the quality of mvoement

Describe the reogranization of the brain theory

Altered physiological response in intrinsic neuronal networks


--Long term potentiation/depression




Altered neuro transmitter levels




Anatomical changes in neuron structure


--Dendritic branching


--Axonal sprouting


--Synaptogenesis

What is the temporal contiguity hypothesis

The normal representation of body surface in the brain is maintained thru daily use




Change the daily pattern of use, and in a relatively short period of time distribution within the cortical map changes

Review table on Slide 15

Recovery vs Compensation