Cholinomimetics Direct And Indirect

Front 1

Heterotropic presynaptic inhibition

Back 1

Symp and parasymp in the heart

Front 2

Pre synaptic inhibition example

Back 2

Noradren. And cholinergic

Front 3

Hemicholium

Back 3

Choline carrier antagonist

Front 4

Non depolarsing blocking agents

Back 4

Tubocurarine

Front 5

Botulinum

Back 5

Presynaptic toxin

Front 6

Vesimicol

Back 6

Ach carrier antagonist

Front 7

Post synaptic synergism

Back 7

Hint 7

Npy helps sympa

NA ATP in vessels

Ach Sp in enteric

Ach vip to blood vessels

Front 8

Depolarizing blocking agent

Back 8

Suxamethonium

Front 9

4 sites of Ach receptors

Back 9

Front 10

Blood pressure Ach and Muscarinic receptors

Back 10

Ach > 👆 NO vasodilation

Atropine blocks M achR

At extreme doses of ach... N achR symp. Ganglions activated vasoconstriction and hypertension

Front 11

Cardiac effects of M receptors agonists

Back 11

M2

Front 12

Pulmonary effect M3 agonists

Back 12

Front 13

Vascular effects of M3 agonists

Back 13

Front 14

Ocular effects of M agonists

Back 14

M3

Front 15

Amphetamine mechanisim

Back 15

Hint 15

Extravesicular secretion of NA

Front 16

GI effects M1 and M3 agonists

Back 16

Front 17

Urogenital effects M3

Back 17

Front 18

Cholinomimetics

Back 18

Bethnichol M3 for bladder and gut hypotonia

Pilocarpine for glaucoma by inducing relaxation of the lens by contracting the zonule fibers also acute angle glaucoma by miosis

Carbacholine miosis as well as acting as nicotinic agonist

Methacholine test of asthma (induced bronchoconstriction)

Verriclin nicotinic...

Front 19

Bathanechol

Back 19

M specific

Bladder and GI hypotonia(with no obstruction)

Front 20

Cevimeline

Back 20

M3 specific Sjgron treatment

Front 21

Pilocarpine

Back 21

M specific

Glaucoma improved drainage

Front 22

Effects of M3 agonists on Nasopharyngeal , tear and sweat gland(sympathetic).

Back 22

Front 23

Edrophonium use

Back 23

Short 2 min achE inhibitor

Tense line test > diagnose myasthenia gravis from cholinergic strom

Front 24

Types of achE

Back 24

Front 25

AchE inhibitors intermediate action BBB penetration and use

Back 25

Carbamoyl esters: 6 hours

Physostigmine tertiary

Neostigmine Quat

Pyridostigmine

Demacarium Quat

Used for Glaucoma, bladder and intestinal atonia myasthenia(with atropine)

Tubacuarine reverse

Atropine intoxication

Alzheimer's(damage of chole.neurons)

Front 26

Irreversible AchE Inhibitors effects

Back 26

Front 27

M1 M2 M3

Back 27

Gq. Gi Gq

Cns. Heart. Smooth m.

Enteric. Cardiac - glands blad

Gastric sec. Eye. Vessels

Ip3DAG. 👇 cAMP. Gi

Front 28

Neostigmine use

Back 28

Quat AchE inhibitor

Reverse nicotinicR non depolarising

Inhibitors curare

But no succinylcholine (dep)

Front 29

Prydostigmine use

Back 29

Quat

Treatment of myasthenia gravis

Front 30

Drugs used for alzehimer treatment

Back 30

Tertiary AchE inhibitors

Specifically Galantamine

Rivastigmine

And Donpezil

Front 31

Irreversible AChE inhibitors

Back 31

Parathion malathion

Eyedrop=ecothiopate

Treated with pralidoxim N and M peripheral and ATROPINE central M

Front 32

AchE inhibitors short acting and use

Back 32

Edrophonium 10 min

Used to diagnose myasthenia gravis

Front 33

Use of Physostigmine

Back 33

Tertiary

Atropine intoxication

Front 34

Signs of AchE intox

Back 34

M Tearing sweating incontinence diarrhea and urination

Cns damage tremors and ataxia and coma miosis lacrimation bronchoconstriction bradycardia

DUMBBELLS

N

Paralysis and weakness