Neuropharm Flashcard

Front 1

alpha 1 receptor in eye (Action)

Back 1

pupil dilates

Front 2

Muscarinic repector in eye (action)

Back 2

pupil contracts and lens accommodates for near vision

Front 3

beta 2 receptor in lungs and trachea (action)

Back 3

dilates

Front 4

Muscarinic receptors in the lungs and trachea (action)

Back 4

constricts and increases secretions

Front 5

Nicotinic (neuronal type) receptor in adrenal medulla (action)

Back 5

Epi and NE secretion (remember this is sympathetic and ACh is released onto this receptor by pre-gang. symp. neurons)

Front 6

beta 1 receptors in kidney (action)

Back 6

increases secretion of renin

Front 7

alpha 1 receptors in kidney (action)

Back 7

decreases secretion of renin

Front 8

beta 2, alpha 1 receptors in ureters and bladder (action)

Back 8

relaxes detrusor, contraction of trigone and sphincter

Front 9

muscarinic receptor in ureters and bladder (action)

Back 9

contraction of detrusor, relaxation of trigone and sphincter

Front 10

alpha 1 receptor in male genitalia (action)

Back 10

stimulates ejaculation

Front 11

muscarinic receptor in male genitalia (action)

Back 11

stimulates erection

Front 12

muscarinic receptor in lacrimal glands (action)

Back 12

stimulates tears

Front 13

alpha 1 receptors in salivary glands (action)

Back 13

thick, viscid secretion

Front 14

muscarinic receptors in salivary glands (action)

Back 14

copious, watery secretion

Front 15

beta 1 receptors in the heart

Back 15

increased rate, increased contractility

Front 16

M2 (muscarinic) receptors in the heart

Back 16

decreased rate, decreased contractility

Front 17

beta 2 and alpha 1 receptors in the GI system (actions)

Back 17

decrease in muscle motility and tone; contraction of sphincters

Front 18

muscarinic receptors in GI (action)

Back 18

increased muscle motility and tone

Front 19

beta 2 receptors in the uterus (action)

Back 19

relaxation

Front 20

beta 2 receptors in blood vessels in skeletal mm. (Action)

Back 20

dilation

Front 21

alpha 1 receptors in blood vessels in skin, mucous membranes, and splanchnic area

Back 21

constriction

Front 22

Muscarinic receptor AGONISTS

Back 22

ACh, Bethanechol, Pilocarpine

Front 23

Muscarinic Receptor ANTAGONISTS

Back 23

Tertiary (BBB-Yes) Atropine, scopolamine, tropicamide
Quaternary (BBB- NO)

Front 24

AChE Inhibitors

Back 24

Tertiary: Physostigmine, Donepezil,
Quat: Neostigmine, Edrophonium, Organophospates (irreversible)

Front 25

Pralidoxime

Back 25

cholinesterase reactivator (antidote for organophosphate poisoning) **given with atropine

Front 26

alpha 1, beta 1 and 2 (nonselective)

Back 26

Epi

Front 27

Indirect agonists (releasers)

Back 27

pseudoephedrine, tyramine

Front 28

alpha 1/beta 1 drugs

Back 28

NE

Front 29

alpha 1 (selective)

Back 29

Phenyleprine

Front 30

alpha 2 (selective)

Back 30

Clonidine

Front 31

beta 1 and 2 (non-selective)

Back 31

Isoproterenol

Front 32

beta 2 (selective)

Back 32

albuterol

Front 33

beta 1 (selective)

Back 33

Dobutamine

Front 34

Inhibitors of catechol-O-Methyltransferase (indirect adrenergic agonist)

Back 34

Entacapone

Front 35

Antiadrenergic - inhibitors of NE synthesis

Back 35

alpha-methyl tyrosine, alpha-methyldopa

Front 36

antiadrenergic - inhibitors of NE vesicular uptake and storage

Back 36

Reserpine

Front 37

alpha 1 and 2 antagonists (nonselective)

Back 37

Phentolamine (rev), Phenoxybenzamine (irrev.)

Front 38

alpha 1 antagonist (selective)

Back 38

Prazosin, Tamsulosin

Front 39

beta 1 and 2 antagonists (non-selective)

Back 39

Propranolol

Front 40

beta 1 antagonists (selective)

Back 40

metoprolol, atenolol

Front 41

alpha and beta 1/2 antagonists

Back 41

labetalol

Front 42

botulinum toxin MOA

Back 42

inhibits ACh release by attacking synaptobrevin

Front 43

black widow spider venom MOA

Back 43

increases ACh release by attacking neurexin

Front 44

NMJ competitive blockers (non depolarizing)

Back 44

Curare, Atacurium, Rocuronium

Front 45

NMJ depolarizing blocker

Back 45

Succinylcholine

Front 46

myasthenia gravis - diagnostic

Back 46

edrophonium

Front 47

myasthenia gravis - treatment

Back 47

cholinesterase inhibitors (Neostig.)
immunosuppressants (Prednisone)

Front 48

Cholinergic Agonists (7)

Back 48

1. Pilocarpine (M)
2. Bethanechol (M)
3. Physostigmine (i)
4. Neostigmine (i)
5. Edrophonium (i)
6. Donepezil (i)
7. Organophosphates (i)

Front 49

Cholinergic Antagonists (7)

Back 49

1. Atropine (M)
2. Scopolamine (M)
3. Ipratropium (M)
4. Dicyclomine (M)
5. Tolterodine (M)
6. Succinylcholine (Nm)
7. Tubocurarine (Nm)