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13 Cards in this Set
- Front
- Back
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atropine is given to a patient, what is its action and how can it be overcome?
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competitively blocks ACh receptor binding. Overcome by increasing endogenous ACh
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What does the degree of effectiveness of antimuscarinics depend on?
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endogenous tone of ACh. Higher doses makes antimusc's less.
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In general, what kind of global effect do antimuscs have on the nervous system?
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anti-parasympathetic
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What are side effects of ChE inhibitor overdose?
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Muscarinic: vomitting, diarrhea, sweating, bronchial constricxn/secretions; Nico: weakness, twitching, paralysis
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What would you give someone who has overdosed on organophosphates or expossed to nerve gas?
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atropine to block excess ACh that results from ChE inhibition
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To avoid vagal slowing of the heart in certain surgical patients, what is administered?
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antimuscarinic
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A nerve block from surgery must be overcome. What is administered?
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Neostigmine (ChE inhibitor to incr ACh)
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If neostigmine administered to overcome nerve block, what might be some side effects? How overcome?
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Brachycardia, NM problems, incr salivation, etc. Administer anti-musc to overcome
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A patient has a severe asthma attack. What 2 drugs could you administer together and what are their mechanisms?
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Ipratropium- M3 antagonist in lungs and Beta2 agonist to dilate smooth muscle in bronchioles
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What is the problem at the neuronal level that occurs in Parkinsons?
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dopaminergic (inhibitory) neurons lost in sub nigra.
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How can antimuscarinic drugs be helpful in tx of Parkinsons?
For which patients is it most useful? |
reduce cholinergic tone and restore the balance between cholinergic and dopaminergic input. Best for tremor Parkinsons
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What are the contraindications for antimuscarinic drugs?
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anything were the blockade of PSNS or skeletal muscle receptors causes probs: glaucoma (cholinergic drugs relieve), GI disease, MG
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What is the best tx for antimuscarinic poisoning? why?
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physostigmine, ChE inhibitor allows more ACh to circulate and it crosses BBB
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