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367 Cards in this Set
- Front
- Back
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NVP
|
ChAT inhibitor
|
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Juglone
|
ChAT inhibitor
|
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Hemicholinium-3 (HC-3)
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HACU inhibitor
|
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Triethylcholine (TEC)
|
HACU inhibitor
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AH5183 (Vesamicol)
|
VAChT inhibitor
|
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Edrophonium (Tensilon)
|
Reversible AChE inhibitor
|
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Physostigmine
|
Reversible AChE inhibitor
|
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Neostigmine (Prostigmin)
|
Peripheral Reversible AChE inhibitor
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Parathion
|
Irreversible AChE inhibitor
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Malathion
|
Irreversible AChE inhibitor
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Sarin
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Irreversible AChE inhibitor
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Soman
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Irreversible AChE inhibitor
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Tabun
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Irreversible AChE inhibitor
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DFP
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Irreversible AChE inhibitor
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Pralidoxime Iodide
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Antidote for Organophospates
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Pirenzepine
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M1 antagonist
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AF-Dx 116
|
M2 antagonist
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HHSiD
|
M3 antagonist
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Methoctramine
|
M4 antagonist
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m1, m3, m5
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Stimulate PI
Increase Ca2+ Increase cAMP Increase arachadonic acid, Inhibit M-current (K+), Activate Ca2+ dependent K and Cl currents |
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m2, m4
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Inhibit AC
Stimulate inward rectified K+ Inhibit Ca2+ |
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Carbachol
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cholinomimetic
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Methacholine
|
cholinomimetic
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Methycarbacol
|
nicotinic agonist
|
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DMPP
|
nicotinic agonist
|
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Succinylcholine
|
nicotinic agonist (muscle, depol block)
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decmaethonium
|
nicotinic agonist (muscle (depol block)
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anatoxin-a
|
nicotinic agonist
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nicotine
|
nicotinic agonist
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d-tubocurarine
|
nicotinic antagonist (muscle prefered)
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gallamine (Flaxedil)
|
nicotinic antagonist (prefers muscle)
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hexamethonium
|
nicotinic antagonist (prefers ganglia)
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mecamylamine (inversine)
|
nicotinic antagonist (prefers ganglia)
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muscarine
|
muscarinic agonist
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pilocarpine
|
muscarinic agonist
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oxotremorine
|
muscarinic agonist
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McN-A-343
|
M1 agonist
|
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Atropine (hyoscamine)
|
Muscarinic antagonist
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scopolomine (hyoscine)
|
muscarinic antagonist
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QNB
|
muscarinic antagonist
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Pirezepine
|
M1 antagonist
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AF-DX 116
|
m2 antagonist
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pancuronium (pavulon)
|
nicotinic antagonist
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SFK38393
|
D1 agonist
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SFK82526
|
D1 agonist
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Dihyrexidine
|
D1 agonist
|
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Apomorphine
|
D2 agonist
|
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Bromocriptine
|
D2 agonist
|
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Quinpirole
|
D2/D3 agonist
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Pergolide
|
D2/D3 agonist
|
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SCH23390
|
D1 antagonist
|
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NNC112
|
D1 antagonist
|
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SCH39166
|
D1 antagonist
|
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Haloperidol
|
D2 antagonist
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sulpiride
|
D2 antagonist
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Spiperone
|
D2 antagonist
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YM-09151-2
|
D2 antagonist
|
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S14297
|
D3 antagonist
|
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Clozapine
|
D3 antagonist
|
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AMPT
|
Tyrosine Hydroxylase inhibitor
|
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NSD105
|
L-AADC inhibotr
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Pheylephrine
|
alpha1 agonist
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Methoxamine
|
alpha1 agonist
|
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clonidine
|
alpha2 agonist
|
|
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B-HT920
|
alpha2 agonist
|
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Isoproterenol
|
Beta agonist
|
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albuterol
|
beta agonist
|
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denopramine
|
beta1 agonist
|
|
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xamoterol
|
beta1 agonist
|
|
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procaterol
|
beta2 agonist
|
|
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brl37344
|
beta3 agonist
|
|
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cl316,243
|
beta3 agonist
|
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prazosin
|
alpha1 antagonist
|
|
|
wb-4101
|
alpha1 antagonist
|
|
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phenoxybenzamine
|
alpha1 antagonist
|
|
|
yohimbine
|
alpha2 antagonist
|
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rauwolscine
|
alpha2 antagnoist
|
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idazoxan
|
alpha2 antagonist
|
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propranolol
|
beta antagonist
|
|
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alprenolol
|
beta antagonist
|
|
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pindolol
|
beta antagonist
|
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|
atenolol
|
beta1 antagonist
|
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bisopropolol
|
beta1 antagonist
|
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ICI-118,551
|
beta2 antagonist
|
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Carbidopa
|
L-AADC inhibitor
|
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NSD-1015
|
L-AADC inhibitor
|
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DDC
|
CU2 Chelator
|
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Fusaric acid
|
DBH inhibitor
|
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3-phenylpropargylamine
|
DBH inhibitor
|
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tetrabenazine (nitoman)
|
VMAT inhibitor
|
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reserpine (Serpasil)
|
VMAT inhibitor
|
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Cocaine
|
Catachol uptake inhibitor
|
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amphetamine
|
catachol uptake inhibitor/releasing agent
|
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methylphenidate
|
catachol uptake inhibitor (more potent at NET)
|
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nomifensine
|
catachol uptake inhibitor (more potent at NET)
|
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Mazindol
|
catachol uptake inhibitor (more potent at NET)
|
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|
imipramine
|
5-ht and NE reuptake inhibitor, TCA
|
|
|
amitriptyline
|
inhibit 5-ht and NE reuptake, TCA
|
|
|
desipramine
|
TCA, NE reuptake inhibitor
|
|
|
protryptyline
|
TCA, NE reuptake inhibitor
|
|
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nortrpytline
|
TCA, NE reuptake inhibitor
|
|
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nisoxetine
|
NE reuptake inhibitor
|
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benztropine
|
DA reuptake inhibitor
|
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GBR12909
|
DA REUPTAKE INHIBITOR
|
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GBR12935
|
DA reuptake inhibitor
|
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GBR12783
|
DA reuptake inhibitor
|
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S-adenosyl-methionine (SAM)
|
cofactor form COMT, acts as methyl donor
|
|
|
COMT (Catachol-o-methyltransferase)
|
methylates catachols, inactivating them.
|
|
|
pyrogallol
|
COMT inhibitor
|
|
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Tropolone
|
COMT inhibitor
|
|
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Ro 410960
|
nitrocatechol family member, COMT inhibitor
|
|
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OR-462
|
nitrocatechol family of COMT inhibitors
|
|
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Entacapone
|
COMT inhibitor
|
|
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Isocarboxazid (Marplan)
|
irreversible MAO inhibitor
|
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Tranylcypromine (parnate)
|
irreversible MAO inhibitor
|
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Pargyline
|
irreversible MAO inhibitor
|
|
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Iproniazid (Marsilid)
|
irreversible MAO inhibitor
|
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phenelzine (Nardil)
|
irreversible MAO inhibitor
|
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Clorgyline
|
Irreversible MAO-A inhibitor
|
|
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Deprenyl (Selegiline)
|
Irreversible MAO-A inhibitor
|
|
|
Moclobemide (Aurorix)
|
reversible MAO-A inhibitor
|
|
|
3,4-dihydroxyphenylacetaldeyde (DHPA)
|
product of DA catabolism by MAO (deamination)
|
|
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3,4-dihydroxyphenylacetic acid (DOPAC)
|
product of DHPA catabolism by aldehyde dehyrogenase
|
|
|
homovanillic acid (HVA)
|
product of DOPAC o-methylation by COMT
product of MHPA dehydorgenation by aldehyde dehydrogenase |
|
|
3-methoxytyramine (3-MT)
|
Product of DA o-methylation by COMT
|
|
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3-Methoxy-4-hydroxyphenylacealdehyde (MHPA)
|
product of 3-MT deamination by MAO
|
|
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3,4-dihydroxyphenylglycoaldehyde (DHPGA)
|
product of NE deamination via MAO
|
|
|
Noretanephrine
|
product of NE o-methylation of NE by COMT
|
|
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3,4-dihydrophenylglycol (DHPG)
|
product of reduction of DHPGA by aldehyde reductase
|
|
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3,4-dihydromandelic acid (DHMA)
|
product of DHPGA dehydrogenation by Aldehyde dehydrogenase
|
|
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3-methoxy-4-hydroxyphenylglycol (MHPG)
|
product of DHPG o-methylation by COMT
product of MHPGA dehydrogenation by aldehyde dehydrogenase |
|
|
Vanillymadelic acid (VMA)
|
product of DHMA o-methylation by COMT
product of MHPGA dehydrogenation by aldehyde dehydrogenase |
|
|
6-OHDA
|
a DA analog taken up by DA and NE transporters
Catachol neurotoxin |
|
|
DSP-4
|
NE neurotoxin
|
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A9 cell group
|
Substantia Nigra
|
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A10 cell group
|
VTA
|
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A8 cell group
|
retrorubral nucleus
|
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A11 cell group
|
cadaul thalamus
|
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A13 cell group
|
zona incerta
|
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A14 cell group
|
periventricular hypothalamas
|
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A15 cell group
|
Olfactory bulb
|
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a12 cell group
|
arcuate nucleus
|
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|
Globus pallidus recieves DA from:
|
A9 (Nigra)
|
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NuAcc recieves DA from
|
A10 (VTA)
|
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Ventral Striatum recieves DA from:
|
A9 (Nigra)
|
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Olfactory Bulb recieves DA from:
|
A10 (VTA)
|
|
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Lateral septum recieves DA from
|
A10
|
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Pyriform ctx receives DA from
|
A10, medial A9
|
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Amygdala recieves DA from
|
A10, medial A9
|
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Hippocampus recieves DA from
|
A10, A9
|
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Locus coeruleus receives DA from
|
A10, A9
|
|
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GBL (gamma-beutyolactone)
|
inhibits impulse flow in DA neurons
|
|
|
SFK-38393
|
D1 agonist
|
|
|
SFK-81297
|
D1 agonist
|
|
|
SFK-82526 (Fenoldopam)
|
D1 agonist
|
|
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Dihyrexidine
|
D1 agonist
|
|
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SCH-23390
|
D1 antagonist
|
|
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SKF-83566
|
D1 antagonist
|
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NNC-112
|
D1 antagonist
|
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SCH-39166
|
D1 antagonist
|
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D1 family of receptors
|
D1, D5 --> both stimulate AC
|
|
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D2 family of receptors
|
D2, D3, D4
|
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Bromocriptine
|
D2 agonist
|
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Apomorphine
|
D2 agonist
|
|
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LY-171555 (quinpirole)
|
D2 agonist
|
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Pergolide
|
D2 agonist (w/ some D1 activity)
|
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Haloperidol
|
D2 antagonist
|
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pimozide
|
d2 antagonist
|
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raclopride
|
d2 antagonist
|
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sulpiride
|
d2 antagonist
|
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spiperone
|
d2 antagonist
|
|
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YM-09151-2
|
D2 antagonist
|
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domperidone
|
peripheral d2 antagonist
|
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7-OH-DPAT
|
d3 agonist
|
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CGP-25454A
|
DA2 antagonist, prefers autoreceptorss
|
|
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A5/A7
|
lateral tegmental system (NE)
|
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A1/A2
|
medullary group (A1)
|
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A6
|
Locus Coeruleus
|
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Adrenegeric receptors in heart
|
B receptor, increase rate and force of contraction
|
|
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Adrengeric receptor in blood vessels
|
alpha, constrict
beta, dialate |
|
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Trachael and bronchial smooth muscle ADRENGERIC RECEPTOR
|
beta, relax
|
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UTERINE SMOOTH MUSCLE ADRENOCEPTORS
|
CONTRACT, ALPHA
|
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BLADDER ADRENOCEPTORS
|
ALPHA CONTRACT
BETA RELAX |
|
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IRIS ADRENOCEPTORS
|
DIALATE PUPIL, ALPHA
|
|
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ADIPOSE TISSUE
|
INCREASED LIPOLYSIS, BETA
|
|
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ALPHA1 ADRENCOCEPTORS
|
POST SYNAPTIC, Gq, PLC
|
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Alpha2 adrenoceptors
|
pre and post synaptic, Gi, inhibit cAMP
|
|
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Beta1 adrenoceptors
|
Gs increase cAMP
|
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Beta2 adrenoceptors
|
Gs increase cAMP
|
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Beta3 adrenoceptors
|
Gs increase cANP
|
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Phenylephrine
|
Alpha1 agonist
|
|
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Methoxamine
|
alpha1 agonist
|
|
|
cirazoline
|
alpha1 agonist
|
|
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prazosin
|
alpha1 antag
|
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phenoxybenzamine
|
alpha1 antag
|
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clonidine
|
alpha2 agonist
|
|
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yohimbine
|
alpha2 agonsit
|
|
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rauwolscine
|
alpha2 agonist
|
|
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idazoxan
|
alpha2 agonist
|
|
|
5-methylurapidil
|
alpha2 antag
|
|
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chloroethylclonidine
|
alpha2 antag
|
|
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isopropterenol
|
general beta agonist
|
|
|
albuterol
|
general beta agonist
|
|
|
propranolol
|
general beta antagonist
|
|
|
alprenolol
|
general beta antagonist
|
|
|
pindolol
|
general beta antagonist
|
|
|
denopamine
|
b1 agonist
|
|
|
Ro-363
|
b1 agonist
|
|
|
xamoterol
|
b1 agonist
|
|
|
procaterol (OPC2009)
|
b2 agonist
|
|
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sulfonterol
|
b2 agonist
|
|
|
atenolol
|
b1 antagonist
|
|
|
bisoprolol
|
b1 antag
|
|
|
cgp20712a
|
b1 antag
|
|
|
ICI118551
|
B2 antag
|
|
|
CL 316243
|
B3 agonist
|
|
|
BRL 37344
|
B3 agonist
|
|
|
alpha1 signaling
|
Increase IP3 increase Ca2
slow depol |
|
|
alpha2 signaling
|
decrease cAMP, slow hyperpol
|
|
|
Beta singaling
|
increase cAMP, decrease spike frequency adaptation
|
|
|
methoxamine (Vasoxyl)
|
alpha 1 agonist
|
|
|
alpha methyl DOPA (Aldomet)
|
inhibits LAADC, converted to alpha methyl NE which is an a2 agonist
|
|
|
clonidine
|
a2 agonist
|
|
|
6-fluorotryptophan
|
TrypHydroxylase inhibitor
|
|
|
alpha-n-propyldopacetamide (h22/54)
|
TrypHydroxylase inhibitor
|
|
|
p-chloroamphetamine
|
TrypHydroxylase inhibitor
and 5HT releasing agent |
|
|
8-OH-DPAT
|
5HT1a agonist
|
|
|
Buspirone
|
5HT1a agonist
|
|
|
Ipsapirone
|
5HT1a agonist
|
|
|
CP-93,129
|
5ht1b agonist
|
|
|
RU24969
|
5HT1b agonist
|
|
|
m-CPP
|
5HT1b agonist, 2c agonist
|
|
|
DOM
|
5HT2 agonist
|
|
|
MK212
|
5HT2b agonist
|
|
|
m-Chlorophenylbiguanide
|
5HT3 agonist
|
|
|
n Butyl renzapride
|
5-HT4 agonist
|
|
|
SDZ 216-525
|
5ht1a antag
|
|
|
WAY100135
|
5HT1a antag
|
|
|
5-nonyloxytrpyamine
|
5-ht1b antag
|
|
|
ketanserin
|
5-ht2 antag
|
|
|
ritanserin
|
5-ht2 antag
|
|
|
mesulergine
|
5-ht2 antag
|
|
|
ondansetron
|
5-ht3 antag
|
|
|
GR113909
|
5-HT4 antag
|
|
|
p-fluoroamphetamine
|
5HT releasing agent
|
|
|
p-chloromethamphetamine
|
5HT releasing agent
|
|
|
p=methoxyamphetamine
|
5HT releasing agent
|
|
|
fenfluramine
|
5HT releasing agent
|
|
|
citalopram
|
SSRI
|
|
|
Dihydrexidine (DHX)
|
D1 agonist
|
|
|
Amitrptyline (evail)
|
tertiary amine tryciclics, NE, 5HT
|
|
|
Clomipramine (Anafranil)
|
tertiary amine tryciclics, NE, 5HT
|
|
|
Doxepin (Adapin, Sineqaun)
|
tertiary amine tryciclics Ne, 5HT
|
|
|
Imipramine (Tofranil)
|
tertiary amine tryciclics, NE, 5HT
|
|
|
Trimipramine (Surmontil)
|
tertiary amine tryciclics, Ne, 5HT
|
|
|
Amoxapine (Asendin)
|
secondary amine tricylics, DA, NE
|
|
|
desipramine (Norpramin)
|
secondary amine tricyclic, NE
|
|
|
Marpotiline (Ludiomil)
|
secondary amine tryciclics, NE
|
|
|
Nortriptyline (Pamelor)
|
secondary amine tricyclic, NE
|
|
|
Protriptyline (Vivactil)
|
secondary amine tricyclic, Ne
|
|
|
citalopram (celexa)
|
SSRI
|
|
|
escitalopram (lexapro)
|
Ssri
|
|
|
fluoxetine (prozac)
|
ssri
|
|
|
fluvoxamine (luvox)
|
ssri
|
|
|
sertraline (zoloft)
|
ssri
|
|
|
venlafaxine (effexor)
|
ssri
|
|
|
Atomoxetine (strattera)
|
NE reuptake inhibitor
|
|
|
bupropion (wellbutrin)
|
DA, NE
|
|
|
duloxetine (cymbalta)
|
NE, 5HT
|
|
|
Mirtazapine (remeron)
|
5HT, NE
|
|
|
Nefazodone (serzone)
|
5HT
|
|
|
Trazodone (Desyrel)
|
5HT
|
|
|
Phenelzine (Nardil)
|
MAOI
|
|
|
Trancypromine (parnate)
|
MAOI
|
|
|
Selegiline (eldepryl)
|
MAOI
|
|
|
5-hydroxyindolacetaldehyde
|
Product of 5HT metabolism by MAO
|
|
|
5-hydroxyindolaceticacid
|
Product of 5-hydroxyindolacetaldehyde dehydrogenation via aldehyde dehydrogenase.
|
|
|
5,6-dihydroxytryptamine
|
5HT neurotoxin
|
|
|
b1 cell group
|
raphe pallidus
|
|
|
b2 cell group
|
raphe obscurus
|
|
|
b3 cell group
|
raphe magnus
rostral vlMedulla |
|
|
B4 cell group
|
raphe obscurus
|
|
|
b5, b8 cell group
|
median raphe
|
|
|
b6, b7 cell group
|
dorsal raphe
|
|
|
b9 cell group
|
nucleus pontis oralis, supralemniscal region
|
|
|
D system
|
dorsal raphe origination, fine fibers with fusiform varicosities
|
|
|
M system
|
median raphe origins
|
|
|
5HT1a
|
decrease cAMP, open K channel
|
|
|
5HT1b
|
decrease cAMP
|
|
|
5HT1d
|
decrease cAMP
|
|
|
5HT1e
|
decrease cAMP
|
|
|
5HT1f
|
decrease cAMP
|
|
|
5HT2a
|
Increase IP3/DAG
|
|
|
5HT2b
|
increase IP3/DAG
|
|
|
alpha-methyl-5HT
|
5HT2a agonist
|
|
|
Ketanserin
|
2a antag
|
|
|
ritanserin
|
2a antag
|
|
|
sumatriptan
|
5-HT1d agonist
|
|
|
ipsapirone
|
5HT1a agonist
|
|
|
5HT2c
|
Increase IP3/DAG
|
|
|
5HT3
|
cation channel
|
|
|
5-HT4
|
Increase cAMP
|
|
|
tropisetron
|
5ht3 antag
|
|
|
ondansetron
|
5ht3 antag
|
|
|
Alpha-ketogluterate
|
glutamate precursor, formed by transamination, via aminotransferases
|
|
|
Aminotransferase
|
Catalyzes alpha-ketogluterate to glutamte
|
|
|
Pyridoxal phosphate
|
glutamte to alpha ketogluterate
|
|
|
glutamine
|
precursor, to Glutamate via glutmainase
|
|
|
AMPA
|
alpha amino3hydroxy5methyl4isoxazole proprionic acid
|
|
|
Glur1-Glur4
|
AMPA genes
|
|
|
GluR5-7, KA1, KA2
|
kainate genes
|
|
|
NMDA
|
N-METHYL-D-aspartate
|
|
|
NR1, NR2a-d
|
genes for NMDA receptor
|
|
|
mGluR1-7
|
genes for MgluR's coupled to IP3, DAG, and cKaini
|
|
|
quisqualic acid
|
AMPA/Kainate agonist
|
|
|
CNQX
|
AMPA/kainate antag
|
|
|
NBQX
|
AMPA/Kainate Antag
|
|
|
CPP
|
NMDA antagonist
|
|
|
APV
|
NMDA antagonist
|
|
|
AP7
|
NMDA antagonist
|
|
|
alpha-methyl-4-carboxyphenyl-glycine
|
mGluR antag
|
|
|
Ibotenic acid
|
NMDA receptor agonist
|
|
|
d-Serine
|
agonist at NMDA glycine site
|
|
|
Group I mGluRs
|
mGluR1, mGluR5 --> ACPD sensitive, + linked to IP3
|
|
|
Group II mGluRs
|
mGluR2, mGluR3 --> sensitive to ACPD, inhibit cAMP
|
|
|
Group III mGluRs
|
mGluR4, mGluR6, and mGluR7
|
|
|
AP4
|
agonist at Grp III mGluRs
|
|
|
l-SOP
|
agonist at Grp III mGluRs
|
|
|
Riluzole
|
glutamte release inhibitor
|
|
|
Glutamic Acid Decarboxylase
|
Glutamte to GABA
|
|
|
GABA aminotransferase
|
converts GABA to succinic semialdehyde
|
|
|
Succinic semialdehyde dehydrogenase
|
converts succinic semiladehyde to succinate
|
|
|
muscimol
|
GABAa agonist
|
|
|
THIP
|
GABAa agonist
|
|
|
isoguvacine
|
GABAa agonist
|
|
|
Baclofen
|
GABAb agonist
|
|
|
saclofen
|
GABAb agonist
|
|
|
Bicuculline
|
GABAa antagonist
|
|
|
pentylenetetrazol
|
GABAa antagonist
|
|
|
picrotoxin
|
GABAa antagonist
|
|
|
phaclofen
|
GABAb antagonist
|
|
|
2-hydroxysaclofen
|
GABAb antagonist
|
|
|
Allylglycine
|
inhibits GAD
|
|
|
AOAA
|
inhibits GABA-T
|
|
|
DABA
|
inhibits GABA reuptake
|
|
|
Vigabatrin
|
blcoks GABA-T
|
|
|
EOS (ethanolamine-o-sulfate)
|
GABA-T inhibitor
|
|
|
3-mercaptoproprionic acid
|
GAD inhibitor
|
|
|
Medazepam (Nobrium)
|
Benzo
|
|
|
Chlordiazepoxide (Librium)
|
Benzo
|
|
|
Flurazepam (Dalmane)
|
Benzo
|
|
|
Bromazepam
|
benzo
|
|
|
Diazepam (Valium)
|
Benzo
|
|
|
Fliunitrazepam (Rohpynal)
|
Benzo
|
|
|
Clonazepam (Klonopin)
|
benzo
|
|
|
Alprazolam (Xanax)
|
benzo
|
|
|
PK11195
|
agonist at peripheral BZ receptors
|
|
|
3-alpha-OH-DHP
|
progesterone metabolite
Enhance binding of BZP to BZ site |
|
|
THDOCD
|
corticosterone metabolite enhance binding of BZP to BZ site
|
|
|
alpha6, alpha4 containing GABAa receptors
|
Diazepam insensitive
|
|
|
Zolpidem (Ambien)
|
non-BZP GABA agonist
|
|
|
CGP35348
|
GABAb antag
|
|
|
Tiagabine
|
blocks GABA uptake
|
|
|
Strychnine
|
Glycine antagonist
|
|
|
alpha-Fluoromethylhistidine
|
Histamine neurotoxin
|
|
|
Histidine decarboxylase
|
converts histidine to histamine
|
|
|
Histamine N methyl transferase
|
catabolizes histamine
|
