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367 Cards in this Set

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NVP
ChAT inhibitor
Juglone
ChAT inhibitor
Hemicholinium-3 (HC-3)
HACU inhibitor
Triethylcholine (TEC)
HACU inhibitor
AH5183 (Vesamicol)
VAChT inhibitor
Edrophonium (Tensilon)
Reversible AChE inhibitor
Physostigmine
Reversible AChE inhibitor
Neostigmine (Prostigmin)
Peripheral Reversible AChE inhibitor
Parathion
Irreversible AChE inhibitor
Malathion
Irreversible AChE inhibitor
Sarin
Irreversible AChE inhibitor
Soman
Irreversible AChE inhibitor
Tabun
Irreversible AChE inhibitor
DFP
Irreversible AChE inhibitor
Pralidoxime Iodide
Antidote for Organophospates
Pirenzepine
M1 antagonist
AF-Dx 116
M2 antagonist
HHSiD
M3 antagonist
Methoctramine
M4 antagonist
m1, m3, m5
Stimulate PI
Increase Ca2+
Increase cAMP
Increase arachadonic acid, Inhibit M-current (K+), Activate Ca2+ dependent K and Cl currents
m2, m4
Inhibit AC
Stimulate inward rectified K+
Inhibit Ca2+
Carbachol
cholinomimetic
Methacholine
cholinomimetic
Methycarbacol
nicotinic agonist
DMPP
nicotinic agonist
Succinylcholine
nicotinic agonist (muscle, depol block)
decmaethonium
nicotinic agonist (muscle (depol block)
anatoxin-a
nicotinic agonist
nicotine
nicotinic agonist
d-tubocurarine
nicotinic antagonist (muscle prefered)
gallamine (Flaxedil)
nicotinic antagonist (prefers muscle)
hexamethonium
nicotinic antagonist (prefers ganglia)
mecamylamine (inversine)
nicotinic antagonist (prefers ganglia)
muscarine
muscarinic agonist
pilocarpine
muscarinic agonist
oxotremorine
muscarinic agonist
McN-A-343
M1 agonist
Atropine (hyoscamine)
Muscarinic antagonist
scopolomine (hyoscine)
muscarinic antagonist
QNB
muscarinic antagonist
Pirezepine
M1 antagonist
AF-DX 116
m2 antagonist
pancuronium (pavulon)
nicotinic antagonist
SFK38393
D1 agonist
SFK82526
D1 agonist
Dihyrexidine
D1 agonist
Apomorphine
D2 agonist
Bromocriptine
D2 agonist
Quinpirole
D2/D3 agonist
Pergolide
D2/D3 agonist
SCH23390
D1 antagonist
NNC112
D1 antagonist
SCH39166
D1 antagonist
Haloperidol
D2 antagonist
sulpiride
D2 antagonist
Spiperone
D2 antagonist
YM-09151-2
D2 antagonist
S14297
D3 antagonist
Clozapine
D3 antagonist
AMPT
Tyrosine Hydroxylase inhibitor
NSD105
L-AADC inhibotr
Pheylephrine
alpha1 agonist
Methoxamine
alpha1 agonist
clonidine
alpha2 agonist
B-HT920
alpha2 agonist
Isoproterenol
Beta agonist
albuterol
beta agonist
denopramine
beta1 agonist
xamoterol
beta1 agonist
procaterol
beta2 agonist
brl37344
beta3 agonist
cl316,243
beta3 agonist
prazosin
alpha1 antagonist
wb-4101
alpha1 antagonist
phenoxybenzamine
alpha1 antagonist
yohimbine
alpha2 antagonist
rauwolscine
alpha2 antagnoist
idazoxan
alpha2 antagonist
propranolol
beta antagonist
alprenolol
beta antagonist
pindolol
beta antagonist
atenolol
beta1 antagonist
bisopropolol
beta1 antagonist
ICI-118,551
beta2 antagonist
Carbidopa
L-AADC inhibitor
NSD-1015
L-AADC inhibitor
DDC
CU2 Chelator
Fusaric acid
DBH inhibitor
3-phenylpropargylamine
DBH inhibitor
tetrabenazine (nitoman)
VMAT inhibitor
reserpine (Serpasil)
VMAT inhibitor
Cocaine
Catachol uptake inhibitor
amphetamine
catachol uptake inhibitor/releasing agent
methylphenidate
catachol uptake inhibitor (more potent at NET)
nomifensine
catachol uptake inhibitor (more potent at NET)
Mazindol
catachol uptake inhibitor (more potent at NET)
imipramine
5-ht and NE reuptake inhibitor, TCA
amitriptyline
inhibit 5-ht and NE reuptake, TCA
desipramine
TCA, NE reuptake inhibitor
protryptyline
TCA, NE reuptake inhibitor
nortrpytline
TCA, NE reuptake inhibitor
nisoxetine
NE reuptake inhibitor
benztropine
DA reuptake inhibitor
GBR12909
DA REUPTAKE INHIBITOR
GBR12935
DA reuptake inhibitor
GBR12783
DA reuptake inhibitor
S-adenosyl-methionine (SAM)
cofactor form COMT, acts as methyl donor
COMT (Catachol-o-methyltransferase)
methylates catachols, inactivating them.
pyrogallol
COMT inhibitor
Tropolone
COMT inhibitor
Ro 410960
nitrocatechol family member, COMT inhibitor
OR-462
nitrocatechol family of COMT inhibitors
Entacapone
COMT inhibitor
Isocarboxazid (Marplan)
irreversible MAO inhibitor
Tranylcypromine (parnate)
irreversible MAO inhibitor
Pargyline
irreversible MAO inhibitor
Iproniazid (Marsilid)
irreversible MAO inhibitor
phenelzine (Nardil)
irreversible MAO inhibitor
Clorgyline
Irreversible MAO-A inhibitor
Deprenyl (Selegiline)
Irreversible MAO-A inhibitor
Moclobemide (Aurorix)
reversible MAO-A inhibitor
3,4-dihydroxyphenylacetaldeyde (DHPA)
product of DA catabolism by MAO (deamination)
3,4-dihydroxyphenylacetic acid (DOPAC)
product of DHPA catabolism by aldehyde dehyrogenase
homovanillic acid (HVA)
product of DOPAC o-methylation by COMT
product of MHPA dehydorgenation by aldehyde dehydrogenase
3-methoxytyramine (3-MT)
Product of DA o-methylation by COMT
3-Methoxy-4-hydroxyphenylacealdehyde (MHPA)
product of 3-MT deamination by MAO
3,4-dihydroxyphenylglycoaldehyde (DHPGA)
product of NE deamination via MAO
Noretanephrine
product of NE o-methylation of NE by COMT
3,4-dihydrophenylglycol (DHPG)
product of reduction of DHPGA by aldehyde reductase
3,4-dihydromandelic acid (DHMA)
product of DHPGA dehydrogenation by Aldehyde dehydrogenase
3-methoxy-4-hydroxyphenylglycol (MHPG)
product of DHPG o-methylation by COMT
product of MHPGA dehydrogenation by aldehyde dehydrogenase
Vanillymadelic acid (VMA)
product of DHMA o-methylation by COMT
product of MHPGA dehydrogenation by aldehyde dehydrogenase
6-OHDA
a DA analog taken up by DA and NE transporters

Catachol neurotoxin
DSP-4
NE neurotoxin
A9 cell group
Substantia Nigra
A10 cell group
VTA
A8 cell group
retrorubral nucleus
A11 cell group
cadaul thalamus
A13 cell group
zona incerta
A14 cell group
periventricular hypothalamas
A15 cell group
Olfactory bulb
a12 cell group
arcuate nucleus
Globus pallidus recieves DA from:
A9 (Nigra)
NuAcc recieves DA from
A10 (VTA)
Ventral Striatum recieves DA from:
A9 (Nigra)
Olfactory Bulb recieves DA from:
A10 (VTA)
Lateral septum recieves DA from
A10
Pyriform ctx receives DA from
A10, medial A9
Amygdala recieves DA from
A10, medial A9
Hippocampus recieves DA from
A10, A9
Locus coeruleus receives DA from
A10, A9
GBL (gamma-beutyolactone)
inhibits impulse flow in DA neurons
SFK-38393
D1 agonist
SFK-81297
D1 agonist
SFK-82526 (Fenoldopam)
D1 agonist
Dihyrexidine
D1 agonist
SCH-23390
D1 antagonist
SKF-83566
D1 antagonist
NNC-112
D1 antagonist
SCH-39166
D1 antagonist
D1 family of receptors
D1, D5 --> both stimulate AC
D2 family of receptors
D2, D3, D4
Bromocriptine
D2 agonist
Apomorphine
D2 agonist
LY-171555 (quinpirole)
D2 agonist
Pergolide
D2 agonist (w/ some D1 activity)
Haloperidol
D2 antagonist
pimozide
d2 antagonist
raclopride
d2 antagonist
sulpiride
d2 antagonist
spiperone
d2 antagonist
YM-09151-2
D2 antagonist
domperidone
peripheral d2 antagonist
7-OH-DPAT
d3 agonist
CGP-25454A
DA2 antagonist, prefers autoreceptorss
A5/A7
lateral tegmental system (NE)
A1/A2
medullary group (A1)
A6
Locus Coeruleus
Adrenegeric receptors in heart
B receptor, increase rate and force of contraction
Adrengeric receptor in blood vessels
alpha, constrict
beta, dialate
Trachael and bronchial smooth muscle ADRENGERIC RECEPTOR
beta, relax
UTERINE SMOOTH MUSCLE ADRENOCEPTORS
CONTRACT, ALPHA
BLADDER ADRENOCEPTORS
ALPHA CONTRACT
BETA RELAX
IRIS ADRENOCEPTORS
DIALATE PUPIL, ALPHA
ADIPOSE TISSUE
INCREASED LIPOLYSIS, BETA
ALPHA1 ADRENCOCEPTORS
POST SYNAPTIC, Gq, PLC
Alpha2 adrenoceptors
pre and post synaptic, Gi, inhibit cAMP
Beta1 adrenoceptors
Gs increase cAMP
Beta2 adrenoceptors
Gs increase cAMP
Beta3 adrenoceptors
Gs increase cANP
Phenylephrine
Alpha1 agonist
Methoxamine
alpha1 agonist
cirazoline
alpha1 agonist
prazosin
alpha1 antag
phenoxybenzamine
alpha1 antag
clonidine
alpha2 agonist
yohimbine
alpha2 agonsit
rauwolscine
alpha2 agonist
idazoxan
alpha2 agonist
5-methylurapidil
alpha2 antag
chloroethylclonidine
alpha2 antag
isopropterenol
general beta agonist
albuterol
general beta agonist
propranolol
general beta antagonist
alprenolol
general beta antagonist
pindolol
general beta antagonist
denopamine
b1 agonist
Ro-363
b1 agonist
xamoterol
b1 agonist
procaterol (OPC2009)
b2 agonist
sulfonterol
b2 agonist
atenolol
b1 antagonist
bisoprolol
b1 antag
cgp20712a
b1 antag
ICI118551
B2 antag
CL 316243
B3 agonist
BRL 37344
B3 agonist
alpha1 signaling
Increase IP3 increase Ca2
slow depol
alpha2 signaling
decrease cAMP, slow hyperpol
Beta singaling
increase cAMP, decrease spike frequency adaptation
methoxamine (Vasoxyl)
alpha 1 agonist
alpha methyl DOPA (Aldomet)
inhibits LAADC, converted to alpha methyl NE which is an a2 agonist
clonidine
a2 agonist
6-fluorotryptophan
TrypHydroxylase inhibitor
alpha-n-propyldopacetamide (h22/54)
TrypHydroxylase inhibitor
p-chloroamphetamine
TrypHydroxylase inhibitor
and
5HT releasing agent
8-OH-DPAT
5HT1a agonist
Buspirone
5HT1a agonist
Ipsapirone
5HT1a agonist
CP-93,129
5ht1b agonist
RU24969
5HT1b agonist
m-CPP
5HT1b agonist, 2c agonist
DOM
5HT2 agonist
MK212
5HT2b agonist
m-Chlorophenylbiguanide
5HT3 agonist
n Butyl renzapride
5-HT4 agonist
SDZ 216-525
5ht1a antag
WAY100135
5HT1a antag
5-nonyloxytrpyamine
5-ht1b antag
ketanserin
5-ht2 antag
ritanserin
5-ht2 antag
mesulergine
5-ht2 antag
ondansetron
5-ht3 antag
GR113909
5-HT4 antag
p-fluoroamphetamine
5HT releasing agent
p-chloromethamphetamine
5HT releasing agent
p=methoxyamphetamine
5HT releasing agent
fenfluramine
5HT releasing agent
citalopram
SSRI
Dihydrexidine (DHX)
D1 agonist
Amitrptyline (evail)
tertiary amine tryciclics, NE, 5HT
Clomipramine (Anafranil)
tertiary amine tryciclics, NE, 5HT
Doxepin (Adapin, Sineqaun)
tertiary amine tryciclics Ne, 5HT
Imipramine (Tofranil)
tertiary amine tryciclics, NE, 5HT
Trimipramine (Surmontil)
tertiary amine tryciclics, Ne, 5HT
Amoxapine (Asendin)
secondary amine tricylics, DA, NE
desipramine (Norpramin)
secondary amine tricyclic, NE
Marpotiline (Ludiomil)
secondary amine tryciclics, NE
Nortriptyline (Pamelor)
secondary amine tricyclic, NE
Protriptyline (Vivactil)
secondary amine tricyclic, Ne
citalopram (celexa)
SSRI
escitalopram (lexapro)
Ssri
fluoxetine (prozac)
ssri
fluvoxamine (luvox)
ssri
sertraline (zoloft)
ssri
venlafaxine (effexor)
ssri
Atomoxetine (strattera)
NE reuptake inhibitor
bupropion (wellbutrin)
DA, NE
duloxetine (cymbalta)
NE, 5HT
Mirtazapine (remeron)
5HT, NE
Nefazodone (serzone)
5HT
Trazodone (Desyrel)
5HT
Phenelzine (Nardil)
MAOI
Trancypromine (parnate)
MAOI
Selegiline (eldepryl)
MAOI
5-hydroxyindolacetaldehyde
Product of 5HT metabolism by MAO
5-hydroxyindolaceticacid
Product of 5-hydroxyindolacetaldehyde dehydrogenation via aldehyde dehydrogenase.
5,6-dihydroxytryptamine
5HT neurotoxin
b1 cell group
raphe pallidus
b2 cell group
raphe obscurus
b3 cell group
raphe magnus
rostral vlMedulla
B4 cell group
raphe obscurus
b5, b8 cell group
median raphe
b6, b7 cell group
dorsal raphe
b9 cell group
nucleus pontis oralis, supralemniscal region
D system
dorsal raphe origination, fine fibers with fusiform varicosities
M system
median raphe origins
5HT1a
decrease cAMP, open K channel
5HT1b
decrease cAMP
5HT1d
decrease cAMP
5HT1e
decrease cAMP
5HT1f
decrease cAMP
5HT2a
Increase IP3/DAG
5HT2b
increase IP3/DAG
alpha-methyl-5HT
5HT2a agonist
Ketanserin
2a antag
ritanserin
2a antag
sumatriptan
5-HT1d agonist
ipsapirone
5HT1a agonist
5HT2c
Increase IP3/DAG
5HT3
cation channel
5-HT4
Increase cAMP
tropisetron
5ht3 antag
ondansetron
5ht3 antag
Alpha-ketogluterate
glutamate precursor, formed by transamination, via aminotransferases
Aminotransferase
Catalyzes alpha-ketogluterate to glutamte
Pyridoxal phosphate
glutamte to alpha ketogluterate
glutamine
precursor, to Glutamate via glutmainase
AMPA
alpha amino3hydroxy5methyl4isoxazole proprionic acid
Glur1-Glur4
AMPA genes
GluR5-7, KA1, KA2
kainate genes
NMDA
N-METHYL-D-aspartate
NR1, NR2a-d
genes for NMDA receptor
mGluR1-7
genes for MgluR's coupled to IP3, DAG, and cKaini
quisqualic acid
AMPA/Kainate agonist
CNQX
AMPA/kainate antag
NBQX
AMPA/Kainate Antag
CPP
NMDA antagonist
APV
NMDA antagonist
AP7
NMDA antagonist
alpha-methyl-4-carboxyphenyl-glycine
mGluR antag
Ibotenic acid
NMDA receptor agonist
d-Serine
agonist at NMDA glycine site
Group I mGluRs
mGluR1, mGluR5 --> ACPD sensitive, + linked to IP3
Group II mGluRs
mGluR2, mGluR3 --> sensitive to ACPD, inhibit cAMP
Group III mGluRs
mGluR4, mGluR6, and mGluR7
AP4
agonist at Grp III mGluRs
l-SOP
agonist at Grp III mGluRs
Riluzole
glutamte release inhibitor
Glutamic Acid Decarboxylase
Glutamte to GABA
GABA aminotransferase
converts GABA to succinic semialdehyde
Succinic semialdehyde dehydrogenase
converts succinic semiladehyde to succinate
muscimol
GABAa agonist
THIP
GABAa agonist
isoguvacine
GABAa agonist
Baclofen
GABAb agonist
saclofen
GABAb agonist
Bicuculline
GABAa antagonist
pentylenetetrazol
GABAa antagonist
picrotoxin
GABAa antagonist
phaclofen
GABAb antagonist
2-hydroxysaclofen
GABAb antagonist
Allylglycine
inhibits GAD
AOAA
inhibits GABA-T
DABA
inhibits GABA reuptake
Vigabatrin
blcoks GABA-T
EOS (ethanolamine-o-sulfate)
GABA-T inhibitor
3-mercaptoproprionic acid
GAD inhibitor
Medazepam (Nobrium)
Benzo
Chlordiazepoxide (Librium)
Benzo
Flurazepam (Dalmane)
Benzo
Bromazepam
benzo
Diazepam (Valium)
Benzo
Fliunitrazepam (Rohpynal)
Benzo
Clonazepam (Klonopin)
benzo
Alprazolam (Xanax)
benzo
PK11195
agonist at peripheral BZ receptors
3-alpha-OH-DHP
progesterone metabolite
Enhance binding of BZP to BZ site
THDOCD
corticosterone metabolite enhance binding of BZP to BZ site
alpha6, alpha4 containing GABAa receptors
Diazepam insensitive
Zolpidem (Ambien)
non-BZP GABA agonist
CGP35348
GABAb antag
Tiagabine
blocks GABA uptake
Strychnine
Glycine antagonist
alpha-Fluoromethylhistidine
Histamine neurotoxin
Histidine decarboxylase
converts histidine to histamine
Histamine N methyl transferase
catabolizes histamine